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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Mycobacterium leprae (strain Br4923)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-1968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:MLBr01925Imported
OrganismiMycobacterium leprae (strain Br4923)Imported
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_01925.

Structurei

3D structure databases

ProteinModelPortaliB8ZSF2.
SMRiB8ZSF2. Positions 71-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLAGHRNV AAVTRSALSL SFVAACVALL SACIQNQPPA TLPGTTPTVW
60 70 80 90 100
TGSPAPSGML GAEAESMGPP NIITRLNAPD GTQVATAKFE FNNGFATITI
110 120 130 140 150
ATTGVGHLAP GFHGVHIHKV GKCEPSSAGP TGGAPGDFLS AGGHFQVPGH
160 170 180 190 200
TVEPASGNLT SLQVRKDGIG TLVTTTDAFT MNDLLAGQKT AIIIHAGADN
210 220 230 240
FGNIPPERYS QVNGTPGPDA TTISTGDAGK RVACGVIGAD
Length:240
Mass (Da):24,087
Last modified:March 3, 2009 - v1
Checksum:iF042C680D80799DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR72022.1.
RefSeqiWP_010908619.1. NC_011896.1.
YP_002503928.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR72022; CAR72022; MLBr01925.
KEGGimlb:MLBr_01925.
PATRICi18046906. VBIMycLep121698_3662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR72022.1.
RefSeqiWP_010908619.1. NC_011896.1.
YP_002503928.1. NC_011896.1.

3D structure databases

ProteinModelPortaliB8ZSF2.
SMRiB8ZSF2. Positions 71-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi561304.MLBr_01925.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR72022; CAR72022; MLBr01925.
KEGGimlb:MLBr_01925.
PATRICi18046906. VBIMycLep121698_3662.

Phylogenomic databases

eggNOGiCOG2032.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-1968-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923Imported.

Entry informationi

Entry nameiB8ZSF2_MYCLB
AccessioniPrimary (citable) accession number: B8ZSF2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.