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B8ZSC1

- EFTU_MYCLB

UniProt

B8ZSC1 - EFTU_MYCLB

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Protein
Elongation factor Tu
Gene
tuf, MLBr01877
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi83 – 875GTP By similarity
Nucleotide bindingi138 – 1414GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-1916-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf
Ordered Locus Names:MLBr01877
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Elongation factor TuUniRule annotation
PRO_1000201408Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8ZSC1.
SMRiB8ZSC1. Positions 2-395.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 205196tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni62 – 665G2 By similarity
Regioni83 – 864G3 By similarity
Regioni138 – 1414G4 By similarity
Regioni175 – 1773G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
KOiK02358.
OMAiDKYPTLN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZSC1-1 [UniParc]FASTAAdd to Basket

« Hide

MAKAKFERTK PHVNIGTIGH VDHGKTTLTA AITKVLHDKF PNLNESRAFD    50
QIDNAPEERQ RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ 100
MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKS DAVDDEELLE 150
LVEMEVRELL AAQEFDEDAP VVRVSALKAL EGDAKWVESV TQLMDAVDES 200
IPAPVRETDK PFLMPVEDVF TITGRGTVVT GRVERGVVNV NEEVEIVGIR 250
QTTTKTTVTG VEMFRKLLDQ GQAGDNVGLL LRGIKREDVE RGQVVIKPGT 300
TTPHTEFEGQ VYILSKDEGG RHTPFFNNYR PQFYFRTTDV TGVVTLPEGT 350
EMVMPGDNTN ISVTLIQPVA MDEGLRFAIR EGGRTVGAGR VVKIIK 396
Length:396
Mass (Da):43,668
Last modified:March 3, 2009 - v1
Checksum:iD9CB88343C642778
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR71973.1.
RefSeqiYP_002503897.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR71973; CAR71973; MLBr01877.
GeneIDi7325921.
KEGGimlb:MLBr_01877.
PATRICi18046718. VBIMycLep121698_3571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR71973.1 .
RefSeqi YP_002503897.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZSC1.
SMRi B8ZSC1. Positions 2-395.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR71973 ; CAR71973 ; MLBr01877 .
GeneIDi 7325921.
KEGGi mlb:MLBr_01877.
PATRICi 18046718. VBIMycLep121698_3571.

Phylogenomic databases

eggNOGi COG0050.
KOi K02358.
OMAi DKYPTLN.
OrthoDBi EOG6R5C6X.

Enzyme and pathway databases

BioCyci MLEP561304:GJP6-1916-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiEFTU_MYCLB
AccessioniPrimary (citable) accession number: B8ZSC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi