B8ZRZ3 (B8ZRZ3_MYCLB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
RNAse III EMBL CAR71754.1

Gene names

Name:	rnc EMBL CAR71754.1
Ordered Locus Names:	MLBr01659

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. SAAS SAAS011907
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. SAAS SAAS011907
Subcellular location	Cytoplasm By similarity SAAS SAAS011907.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. SAAS SAAS011907 Contains 1 RNase III domain. SAAS SAAS011907

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS011907
Ligand	RNA-binding SAAS SAAS011907
Molecular function	Endonuclease SAAS SAAS011907 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ZRZ3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 84BC036362C92AFE	FASTA	238	25,241
	10 20 30 40 50 60 MTQPRQALLD AFGVDLPDEL LSLALTHRSY AYEHGGLPTN ERLEFLGDAV LSLTITDELF 70 80 90 100 110 120 HRHPDRSEGD LAKLRASVVN TQALAYVARN LSDGGLGVYL LLGRGETNTG GADKSSILAD 130 140 150 160 170 180 GMESLLGAIY LHHGIEVARQ VILRLFGTLL DAAPTLGAGL DWKTSLQELT AARGMGVPSY 190 200 210 220 230 VVTSTGPDHD KEFTAVVVVM DTEYGSGIGH SKKEAEQKAA SAAWKALDVL GGVGKTSV

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR71754.1.
RefSeq	YP_002503770.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZRZ3.
SMR	B8ZRZ3. Positions 3-155.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZRZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000086188; EBMYCP00000081894; EBMYCG00000086381.
GeneID	7325308.
GenomeReviews	Gene locus MLBr01659 in contig FM211192_GR.
PATRIC	18045846. VBIMycLep121698_3139.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017732.
HOGENOM	HBG744556.
OMA	ALTHKSF.
ProtClustDB	PRK00102.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8ZRZ3_MYCLB

Accession

Primary (citable) accession number: B8ZRZ3

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)