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B8ZRR7 (B8ZRR7_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008 EMBL CAR71614.1
Ordered Locus Names:MLBr01519
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase SAAS SAAS023451 HAMAP MF_00008 RuleBase RU000500
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1491 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B8ZRR7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: F1A3055238A35DE2

FASTA26630,141
        10         20         30         40         50         60 
MLIATPYEDL LRLVLDCGVA KMDRTGTGTR SLFGQQLRYD LSVGFPLVTT KKVHFKSVVY 

        70         80         90        100        110        120 
ELLWFLRGDS NVAWLHEHGV NIWDEWASST GDLGPIYGVQ WRSWPTSSGD YIDQISTALD 

       130        140        150        160        170        180 
LLRTEPDSRR IIVSAWNVGE IPQMALPPCH AFFQFYVAQG RLSCQLYQRS ADMFLGVPFN 

       190        200        210        220        230        240 
IASYALLTHM MAAQSGLLVG EFVWTGGDCH IYDNHVEQVQ LQLSREPRAY PELFLAQRDS 

       250        260 
IFDYVYEDVV VTNYDPHPAI KAPVAI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71614.1.
RefSeqYP_002503694.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZRR7.
SMRB8ZRR7. Positions 7-266.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZRR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086158; EBMYCP00000082459; EBMYCG00000085908.
GeneID7325300.
GenomeReviewsGene locus MLBr01519 in contig FM211192_GR.
PATRIC18045306. VBIMycLep121698_2869.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017116.
HOGENOMHBG588098.
OMARMALAPC.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8ZRR7_MYCLB
AccessionPrimary (citable) accession number: B8ZRR7
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info