Skip Header

Contribute Send feedback
Read comments (?) or add your own

B8ZRR3 (DAPA_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:MLBr01513
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Dihydrodipicolinate synthase HAMAP MF_00418
PRO_1000134874

Regions

Region58 – 592Pyruvate binding By similarity

Sites

Active site1711Schiff-base intermediate with substrate By similarity
Binding site1161Pyruvate By similarity
Site1431Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZRR3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 045393FB57853507

FASTA30031,137
        10         20         30         40         50         60 
MTTVGFDVPA RLGTLLTAMV TPFDADGSVD TAAATRLANR LVDAGCDGLV LSGTTGESPT 

        70         80         90        100        110        120 
TTDDEKLQLL RVVLEAVGDR ARVIAGAGSY DTAHSVRLVK ACAGEGAHGL LVVTPYYSKP 

       130        140        150        160        170        180 
PQTGLFAHFT AVADATELPV LLYDIPGRSV VPIEPDTIRA LASHPNIVGV KEAKADLYSG 

       190        200        210        220        230        240 
ARIMADTGLA YYSGDDALNL PWLAVGAIGF ISVISHLAAG QLRELLSAFG SGDITTARKI 

       250        260        270        280        290        300 
NVAIGPLCSA MDRLGGVTMS KAGLRLQGID VGDPRLPQMP ATAEQIDELA VDMRAASVLR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71608.1.
RefSeqYP_002503690.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZRR3.
SMRB8ZRR3. Positions 5-300.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZRR3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086848; EBMYCP00000081641; EBMYCG00000087169.
GeneID7326927.
GenomeReviewsGene locus MLBr01513 in contig FM211192_GR.
PATRIC18045264. VBIMycLep121698_2848.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016215.
HOGENOMHBG358848.
OMAHGCISVV.
ProtClustDBPRK03170.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_MYCLB
AccessionPrimary (citable) accession number: B8ZRR3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents