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B8ZRN2 (PROB_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate 5-kinase
EC=2.7.2.11
Alternative name(s):
Gamma-glutamyl kinase
Short name=GK
Gene names
Name:proB
Ordered Locus Names:MLBr01464
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP MF_00456

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP MF_00456

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP MF_00456

Subcellular location

Cytoplasm By similarity HAMAP MF_00456.

Sequence similarities

Belongs to the glutamate 5-kinase family.

Contains 1 PUA domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA binding

Inferred from electronic annotation. Source: InterPro

glutamate 5-kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Glutamate 5-kinase HAMAP MF_00456
PRO_1000193700

Regions

Domain279 – 35779PUA

Sequences

Sequence LengthMass (Da)Tools
B8ZRN2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 9A9BB823994DCEDE

FASTA36738,135
        10         20         30         40         50         60 
MSVHRDAIRA ARSLVVKVGT NALTTSSGVF DSSRLARLVD AIEARMKAGT DVVIVSSGAI 

        70         80         90        100        110        120 
AAGIEPLGLS LRPKDLATKQ AAASVGQVAL VNSWSAAFAR YGRAVGQVLL TAQDISMRVQ 

       130        140        150        160        170        180 
HTNAQRTLDR LRALHAVAIV NENDTVATNE IRFGDNDRLS AVVAHLVGAE ALVLLSDING 

       190        200        210        220        230        240 
LYDSDPRKNT GARFVPEVTG SADLDGVVAS RGSSLGTGGM VSKMSSALLA ADAGVPVLLA 

       250        260        270        280        290        300 
AAADAATALT DASVGTVFAA RPDRMSARRF WLRYAADSVG SLTLDEGAVW AVVQQRRSLL 

       310        320        330        340        350        360 
AAGITAVSGR FYGGDVVELR GPDATMVARG VVAYDATELA AMMGRSTSEL PCELRRPAVH 


ADDLVSI

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71558.1.
RefSeqYP_002503659.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZRN2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZRN2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086241; EBMYCP00000082478; EBMYCG00000085350.
GeneID7326895.
GenomeReviewsGene locus MLBr01464 in contig FM211192_GR.
PATRIC18045056. VBIMycLep121698_2746.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017499.
HOGENOMHBG507643.
OMATFGDNDM.
ProtClustDBPRK05429.

Family and domain databases

HAMAPMF_00456. ProB.
[Tree]
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
PfamPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF53633. Aa_kinase. 1 hit.
SSF88697. PUA-like. 1 hit.
TIGRFAMsTIGR01027. ProB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROB_MYCLB
AccessionPrimary (citable) accession number: B8ZRN2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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