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B8ZRK9 (ARLY_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:MLBr01413
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000116336

Sequences

Sequence LengthMass (Da)Tools
B8ZRK9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 922E5D4119FB1CF6

FASTA47049,937
        10         20         30         40         50         60 
MSTNQGSLWG GRFAAGPSEA LVALSKSTHF DWVLAPYDIT ASRAHTKMLF RAGLLNEEQR 

        70         80         90        100        110        120 
DGLLAGLDNL AEDVADGSFL PLVTDEDVHA ALERGLIDRV GPDLGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRMWLRDAV RRVAAGALEV VDALANQAAE HSSTIMPGKT HLQSAQPILL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVGRIVD FDKRAAVSPY GSGALAGSSL GLDPDAMAQD LGFPAAADNS VDATAARDFA 

       250        260        270        280        290        300 
AEAAFVFAMI AVDLSRLAED IILWSSTEFG YARLHDSWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLAG LLATLKAQPL AYNRDLQEDK EPVFDSVAQL ELLLPAMAGL VASLTFNVER 

       370        380        390        400        410        420 
MAALAPAGYT LATDIAEWLV RQGVPFRSAH EAAGTAVRVA EGRGVGLEEL TDDELAAISA 

       430        440        450        460        470 
NLTPQVREVL TVEGSVSSRA ARGGTAPSQA AKQLTVVRAN ANQLRQLLMR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71508.1.
RefSeqYP_002503636.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZRK9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZRK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085889; EBMYCP00000082607; EBMYCG00000087593.
GeneID7327221.
GenomeReviewsGene locus MLBr01413 in contig FM211192_GR.
PATRIC18044814. VBIMycLep121698_2625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCLB
AccessionPrimary (citable) accession number: B8ZRK9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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