B8ZRK2 (ARGC_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	MLBr01406

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000123248
Sites
	Active site	153	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8ZRK2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 056619C0A58FBEE5	FASTA	347	36,031
	10 20 30 40 50 60 MSYAIRVAVV GASGYAGGEI LRLLLGHPAY ADDRLTIGTL TAAASSGDTL GEHHPHLTPL 70 80 90 100 110 120 AHRVLESTEL TVLAGHDVVF LGLPHGHSAA LAERLGPETL IIDCGADFRL TDAGAWGRFY 130 140 150 160 170 180 ESPYAGSWPY GLPELPGGRE RLQKARRIAV PGCYPTAILL ALLPAMAEGL IEPAVTVFAV 190 200 210 220 230 240 SGISGAGRAA KTKLLGSEVI GSARAYNIGG THRHTAEIIQ GLRVVTDRAV TVSFTPVLIP 250 260 270 280 290 300 TSRGILAACT ARTSSSLSKL RTAYEKAYQV EPFVYLMPEG QLPFTGAVIG SNAAHIAVAV 310 320 330 340 DEAAETFIAI SAIDNLVKGT AGAAVQSMNL ALGWPEAEGL SVVGVAP

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Br4923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR71501.1.
RefSeq	YP_002503629.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZRK2.
SMR	B8ZRK2. Positions 4-347.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZRK2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000085570; EBMYCP00000082053; EBMYCG00000085339.
GeneID	7326857.
GenomeReviews	Gene locus MLBr01406 in contig FM211192_GR.
PATRIC	18044800. VBIMycLep121698_2618.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000015828.
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_MYCLB

Accession

Primary (citable) accession number: B8ZRK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program