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B8ZRH2

- NADK_MYCLB

UniProt

B8ZRH2 - NADK_MYCLB

Protein

NAD kinase

Gene

nadK

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Binding sitei94 – 941NADUniRule annotation
    Binding sitei193 – 1931NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902NADUniRule annotation
    Nucleotide bindingi163 – 1642NADUniRule annotation
    Nucleotide bindingi204 – 2096NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-1388-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:MLBr01359
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311NAD kinasePRO_1000133577Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561304.MLBr_01359.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZRH2.
    SMRiB8ZRH2. Positions 7-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8ZRH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPRKAAQRT VLLVVHTGRD EATETARRVK KIVGDNGIAL RVLSAEAVDR    50
    GSLHLALDNM RAMGVDIEVV DADPHVAQGC ELVLVLGGDG TFLRAAELAR 100
    TARIPVLGVN LGRIGFLAEA EAEAIDVVLE HVIARSYRVE ERLTLDIVVR 150
    QGGNIIDQGW ALNEASLEKG PRLGVLGVVV EIEGRPVSTF GCDGVLVSTP 200
    TGSTAYAFSA GGPVLWPDLE AILVVPNNAH ALFGRPMVTS PDATVAIELE 250
    ANGNDALVFC DGRREMIIPA GGRLEVTRCA TPVKWARLDS APFTDRLVSK 300
    FRLPVTGWRG K 311
    Length:311
    Mass (Da):33,218
    Last modified:March 3, 2009 - v1
    Checksum:i0AD22150CC82D33B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR71454.1.
    RefSeqiWP_010908290.1. NC_011896.1.
    YP_002503599.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR71454; CAR71454; MLBr01359.
    GeneIDi7326027.
    KEGGimlb:MLBr_01359.
    PATRICi18044604. VBIMycLep121698_2520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR71454.1 .
    RefSeqi WP_010908290.1. NC_011896.1.
    YP_002503599.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZRH2.
    SMRi B8ZRH2. Positions 7-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_01359.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR71454 ; CAR71454 ; MLBr01359 .
    GeneIDi 7326027.
    KEGGi mlb:MLBr_01359.
    PATRICi 18044604. VBIMycLep121698_2520.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci MLEP561304:GJP6-1388-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiNADK_MYCLB
    AccessioniPrimary (citable) accession number: B8ZRH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3