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B8ZRF9

- B8ZRF9_MYCLB

UniProt

B8ZRF9 - B8ZRF9_MYCLB

Protein

Sec-independent protein translocase protein TatC

Gene

tatC

Organism
Mycobacterium leprae (strain Br4923)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.UniRule annotation

    GO - Molecular functioni

    1. protein transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein transport by the Tat complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, TranslocationUniRule annotation, Transport

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-1357-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sec-independent protein translocase protein TatCUniRule annotation
    Gene namesi
    Name:tatCUniRule annotation
    Ordered Locus Names:MLBr01332Imported
    OrganismiMycobacterium leprae (strain Br4923)Imported
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB-HAMAP
    2. TAT protein transport complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell membraneUniRule annotation, Membrane

    Interactioni

    Subunit structurei

    The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

    Protein-protein interaction databases

    STRINGi561304.MLBr_01332.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZRF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421Helical;UniRule annotationAdd
    BLAST
    Transmembranei85 – 10521Helical;UniRule annotationAdd
    BLAST
    Transmembranei118 – 13821Helical;UniRule annotationAdd
    BLAST
    Transmembranei166 – 18621Helical;UniRule annotationAdd
    BLAST
    Transmembranei205 – 22521Helical;UniRule annotationAdd
    BLAST
    Transmembranei226 – 24621Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TatC family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0805.
    KOiK03118.
    OMAiEHLYELR.
    OrthoDBiEOG60SCQS.

    Family and domain databases

    HAMAPiMF_00902. TatC.
    InterProiIPR019820. Sec-indep_translocase_CS.
    IPR002033. TatC.
    [Graphical view]
    PfamiPF00902. TatC. 1 hit.
    [Graphical view]
    PRINTSiPR01840. TATCFAMILY.
    TIGRFAMsiTIGR00945. tatC. 1 hit.
    PROSITEiPS01218. TATC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZRF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLIDHLTEL RTRLLISLAA IVVTTIFGFI WYSHSIFGLE SLGEWLRRPY    50
    CSLPQSARAD ISPDGQCRLL ATAPFDQFML RIKVGMAAGI VLASPVWFYQ 100
    LWAFITPGLY TKERRFTVAF VVPAAVLFAG GTVLAYLVLS KALGFLLIVG 150
    SGVQVTALSG DRYFGFLLNL LVVFGVSFEF PLLIVMLNIA GLLTYQRLKS 200
    WRRGLIFAMF VFAAVFTPGS DPFSMTALGA ALTVLLELAI QLVRLHDKRR 250
    VKHEALIADD EASVIEPPSS IPERSYTATR SHDDVT 286
    Length:286
    Mass (Da):31,623
    Last modified:March 3, 2009 - v1
    Checksum:i57E6DDC22F9B8145
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR71427.1.
    RefSeqiWP_010908277.1. NC_011896.1.
    YP_002503586.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR71427; CAR71427; MLBr01332.
    GeneIDi7326477.
    KEGGimlb:MLBr_01332.
    PATRICi18044472. VBIMycLep121698_2458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR71427.1 .
    RefSeqi WP_010908277.1. NC_011896.1.
    YP_002503586.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZRF9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_01332.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR71427 ; CAR71427 ; MLBr01332 .
    GeneIDi 7326477.
    KEGGi mlb:MLBr_01332.
    PATRICi 18044472. VBIMycLep121698_2458.

    Phylogenomic databases

    eggNOGi COG0805.
    KOi K03118.
    OMAi EHLYELR.
    OrthoDBi EOG60SCQS.

    Enzyme and pathway databases

    BioCyci MLEP561304:GJP6-1357-MONOMER.

    Family and domain databases

    HAMAPi MF_00902. TatC.
    InterProi IPR019820. Sec-indep_translocase_CS.
    IPR002033. TatC.
    [Graphical view ]
    Pfami PF00902. TatC. 1 hit.
    [Graphical view ]
    PRINTSi PR01840. TATCFAMILY.
    TIGRFAMsi TIGR00945. tatC. 1 hit.
    PROSITEi PS01218. TATC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923Imported.

    Entry informationi

    Entry nameiB8ZRF9_MYCLB
    AccessioniPrimary (citable) accession number: B8ZRF9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3