B8ZRB5 (HIS3_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	MLBr01264

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 115	115	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_1000149075

Sequences

	Sequence		Length	Mass (Da)
	B8ZRB5 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 623A2361F6F076E1	FASTA	115	12,582
	10 20 30 40 50 60 MTLDPDIAVR LKRNAEGLFT AVVQERSSGD VLMVAWMDDQ ALARTLETRE ANYYSRSRAE 70 80 90 100 110 QWIKGSTSGN TQHVHSVRLD CDGDTVLLTV DQVGGACHTG AHSCFDSAML LAPQD

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Br4923.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR71359.1.
RefSeq	YP_002503542.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZRB5.
SMR	B8ZRB5. Positions 7-108.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZRB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000087334; EBMYCP00000082646; EBMYCG00000085326.
GeneID	7324684.
GenomeReviews	Gene locus MLBr01264 in contig FM211192_GR.
PATRIC	18044226. VBIMycLep121698_2337.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017128.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_MYCLB

Accession

Primary (citable) accession number: B8ZRB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program