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B8ZRA3 (PLSB_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate acyltransferase
Short name=GPAT
EC=2.3.1.15
Gene names
Name:plsB
Ordered Locus Names:MLBr01246
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length775 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. HAMAP MF_00393

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. HAMAP MF_00393

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_00393.

Domain

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity. HAMAP MF_00393

Sequence similarities

Belongs to the GPAT/DAPAT family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglycerol-3-phosphate O-acyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 775775Glycerol-3-phosphate acyltransferase HAMAP MF_00393
PRO_1000192407

Regions

Motif267 – 2726HXXXXD motif HAMAP MF_00393

Sequences

Sequence LengthMass (Da)Tools
B8ZRA3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 03DD77C778293CDF

FASTA77587,364
        10         20         30         40         50         60 
MTEPDVEISS VLTGEDTLVL ASMDTPAEIE LVMDWLCQQR NRNPDIKFDV LKLPSRNLAP 

        70         80         90        100        110        120 
AALTALVEQL ESDEDRSVVP VRVFWMPPAE RSKLAKLAGL LPGRDPYHPN RRQQRHILKT 

       130        140        150        160        170        180 
DARRALVIAG DSAKVSELRQ YWRDTTVGEN ECDFAQFVTR RAILAMERAE SRILGPQYKS 

       190        200        210        220        230        240 
PRLVKPEILA STRFRAGLEK ISGATVEEAG KMLDELATGW SRASVDLVSV LGRMLSRGFE 

       250        260        270        280        290        300 
PEIDYDEYQV AAMRAALEAH PAVLLFSHRS YIDGAVVPVA MQENRLPPVH VFAGINLSFG 

       310        320        330        340        350        360 
LMGPLLRRSG VIFIRRNIGD NPLYKYVLRE YVGYIVEKRF NLSWSIEGTR SRTGKMLPPK 

       370        380        390        400        410        420 
LGLLTYVADA YLDGRSEDIL LQPVSISFDQ LHETAEYAAY ARGGEKTPEG VAWLYSFIKA 

       430        440        450        460        470        480 
QGERNYGKIY VRFPEAVSMR QYLGAPHGAL VQDQDAKRLA LQKMSFEVAW RILCATPVTA 

       490        500        510        520        530        540 
TALVSALLLT TRGVALTLDQ LHHTLQESLD YLERKQTPVS KSALRLRSRE GVRAAVDALS 

       550        560        570        580        590        600 
SGHPITRVDS GREPVWYITP GNEHAAAFYR NSVIHAFLET SIVELALAHA RHVEGDRMKV 

       610        620        630        640        650        660 
FWAQAMRLRD LLKFDFYFAD SAAFRANIAE EIAWHQNWED RVSGDGDDID AMLLTKRPLI 

       670        680        690        700        710        720 
SDAMLRVFFE AYDIVADVLR DAPADVGQKE LTELALGVGR QYVAQGRVRS GESVSTLLFA 

       730        740        750        760        770 
TAYQVVVDQN LIAPAPDLAE RRMVFRRELR DIRRDFDYVE QIARSRFIVR EFKSR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71341.1.
RefSeqYP_002503530.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZRA3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZRA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086549; EBMYCP00000081969; EBMYCG00000085808.
GeneID7327096.
GenomeReviewsGene locus MLBr01246 in contig FM211192_GR.
PATRIC18044172. VBIMycLep121698_2310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000018019.
HOGENOMHBG565163.
OMAIVPVAMQ.
ProtClustDBPRK03355.

Family and domain databases

HAMAPMF_00393. Glyc3P_acyltrans.
[Tree]
InterProIPR002123. Acyltransferase.
IPR022284. G3P_O-AcylTrfase.
[Graphical view]
PfamPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFPIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLSB_MYCLB
AccessionPrimary (citable) accession number: B8ZRA3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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