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B8ZR24 (SYR_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase
EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:MLBr01127
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium ›

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000198925

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
B8ZR24 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: DBD8A95A9B9831BB

FASTA55059,603
        10         20         30         40         50         60 
MTPADLAELL KTTAIVVLAE RGLDAAALPQ TVTVERPRNP EHGDYSSNLA MQLGKKVGAN 

        70         80         90        100        110        120 
PLELAGWLAE VLAQAGGIAD VEVAGPGFIN MRLDASAQAM IVNTVINADK NFGHSDDLAG 

       130        140        150        160        170        180 
YQINLEFVSA NPTGPIHIGG TRWAAVGDAL GRLLSTQGAA VVREYYFNDH GAQIDRFTNS 

       190        200        210        220        230        240 
LIAAAKGELT PADGYAGTYV TDIAAQVMQQ APYALSLPES EMHETVREIG VDLMFTHIKK 

       250        260        270        280        290        300 
SLHEFGTDFD VYTHEDSMHA SGRVDEAIAR LRDTGNVYEK DGALWLRTSA FGDDKDRVVI 

       310        320        330        340        350        360 
KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG DDPAIVEVLI 

       370        380        390        400        410        420 
GQMVNLVCDG QLVRMSKRSG NVITLDDLVE AIGVDAARYS LIRSSVDTPI DIDLALWSSS 

       430        440        450        460        470        480 
SNENPVYYVQ YAHARLSALA RNAAEFGLIP DTGHLELLSH DKEGALLRTV GEFPQVLKTA 

       490        500        510        520        530        540 
AALREPHRVC RYLEDLAGDY HRFYDSCRVL PQGDEKPTDL HTARLALCQA NRQVIANGLA 

       550 
ILGVSAPERM

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71222.1.
RefSeqYP_002503451.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZR24.
ModBaseSearch...

Protein-protein interaction databases

STRING561304.MLBr_01127.

Proteomic databases

PRIDEB8ZR24.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR71222; CAR71222; MLBr01127.
GeneID7327228.
KEGGmlb:MLBr_01127.
PATRIC18043649. VBIMycLep121698_2054.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycMLEP561304:GJP6-1145-MONOMER.

Family and domain databases

Gene3D3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_MYCLB
AccessionPrimary (citable) accession number: B8ZR24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 13, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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