argS

Functionⁱ

Catalytic activityⁱ

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functionⁱ

arginine-tRNA ligase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

arginyl-tRNA aminoacylation Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation) Alternative name(s): Arginyl-tRNA synthetaseUniRule annotation Short name: ArgRSUniRule annotation
Gene namesⁱ	Name:argSUniRule annotation Ordered Locus Names:MLBr01127
Organismⁱ	Mycobacterium leprae (strain Br4923)
Taxonomic identifierⁱ	561304 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae
Proteomesⁱ	UP000006900 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00123

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000198925	1 – 550	Arginine--tRNA ligaseAdd BLAST		550

Interactionⁱ

Subunit structureⁱ

Monomer.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B8ZR24.
SMRⁱ	B8ZR24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	130 – 140	"HIGH" regionAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01887.
OMAⁱ	NKPLHLG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.30.1360.70. 1 hit. 3.40.50.620. 2 hits.
HAMAPⁱ	MF_00123. Arg_tRNA_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERⁱ	PTHR11956. PTHR11956. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit.
PRINTSⁱ	PR01038. TRNASYNTHARG.
SMARTⁱ	View protein in SMART SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMsⁱ	TIGR00456. argS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B8ZR24-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTPADLAELL KTTAIVVLAE RGLDAAALPQ TVTVERPRNP EHGDYSSNLA 
        60         70         80         90        100
MQLGKKVGAN PLELAGWLAE VLAQAGGIAD VEVAGPGFIN MRLDASAQAM 
       110        120        130        140        150
IVNTVINADK NFGHSDDLAG YQINLEFVSA NPTGPIHIGG TRWAAVGDAL 
       160        170        180        190        200
GRLLSTQGAA VVREYYFNDH GAQIDRFTNS LIAAAKGELT PADGYAGTYV 
       210        220        230        240        250
TDIAAQVMQQ APYALSLPES EMHETVREIG VDLMFTHIKK SLHEFGTDFD 
       260        270        280        290        300
VYTHEDSMHA SGRVDEAIAR LRDTGNVYEK DGALWLRTSA FGDDKDRVVI 
       310        320        330        340        350
KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG 
       360        370        380        390        400
DDPAIVEVLI GQMVNLVCDG QLVRMSKRSG NVITLDDLVE AIGVDAARYS 
       410        420        430        440        450
LIRSSVDTPI DIDLALWSSS SNENPVYYVQ YAHARLSALA RNAAEFGLIP 
       460        470        480        490        500
DTGHLELLSH DKEGALLRTV GEFPQVLKTA AALREPHRVC RYLEDLAGDY 
       510        520        530        540        550
HRFYDSCRVL PQGDEKPTDL HTARLALCQA NRQVIANGLA ILGVSAPERM

Length:550

Mass (Da):59,603

Last modified:March 3, 2009 - v1

Checksum:ⁱDBD8A95A9B9831BB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FM211192 Genomic DNA. Translation: CAR71222.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010908145.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaⁱ	CAR71222; CAR71222; MLBr01127.
KEGGⁱ	mlb:MLBr01127.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	FM211192 Genomic DNA. Translation: CAR71222.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_010908145.1. NC_011896.1.

3D structure databases

ProteinModelPortalⁱ	B8ZR24.
SMRⁱ	B8ZR24.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAR71222; CAR71222; MLBr01127.
KEGGⁱ	mlb:MLBr01127.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K01887.
OMAⁱ	NKPLHLG.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H01RF.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.30.1360.70. 1 hit. 3.40.50.620. 2 hits.
HAMAPⁱ	MF_00123. Arg_tRNA_synth. 1 hit.
InterProⁱ	View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-ligase. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERⁱ	PTHR11956. PTHR11956. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit.
PRINTSⁱ	PR01038. TRNASYNTHARG.
SMARTⁱ	View protein in SMART SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF55190. SSF55190. 1 hit.
TIGRFAMsⁱ	TIGR00456. argS. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYR_MYCLB
Accessionⁱ	B8ZR24Primary (citable) accession number: B8ZR24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
	Last sequence update:	March 3, 2009
	Last modified:	June 7, 2017
	This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - B8ZR24 (SYR_MYCLB)

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Arginine--tRNA ligase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Motif

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B8ZR24 (SYR_MYCLB)

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Arginine--tRNA ligase

argS

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ