B8ZR05 (B8ZR05_MYCLB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
2-oxoglutarate dehydrogenase, E1 and E2 components EMBL CAR71190.1

Gene names

Name:	odhA EMBL CAR71190.1
Ordered Locus Names:	MLBr01095

Organism

Mycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]

Taxonomic identifier

561304 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	1260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423

Ontologies

Keywords
Ligand	Thiamine pyrophosphate SAAS SAAS001017
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8ZR05 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D55150D155EE3FE7	FASTA	1,260	139,393
	10 20 30 40 50 60 MQKVASVAQC ACRTEELRRT AAVANISSPF GQNEWLVEEM YRKFRDDPSS VDPSWHEFLV 70 80 90 100 110 120 DYNPESTAEP VLTDPTSTDK QPSATPQAKP AAAADPVASR AKPATTPTVA NGTAAGSAAA 130 140 150 160 170 180 PAKTTTTPPI EGDELQVLRG AAAVVVKNMS ASLDVPTATS VRAVPAKLMI DNRTVINNQL 190 200 210 220 230 240 KRNRGGKISF THLLGYALVQ AVKKFPNINR HYAEIDGKPI AVTPAHTNLG LAIDLQGKDG 250 260 270 280 290 300 KRSLVVAGIK RCEELRFAQF VTAYEDIVRR ARDGKLTAED FAGVTISLTN PGTIGTVHSV 310 320 330 340 350 360 PRLMTGQGAI IGVGAMEYPA EFQGASAERI AELGIGKLIT LTSTYDHRII QGAESGDFLR 370 380 390 400 410 420 TIHEMVLSDS FWDEIFRELS IPYLPVRWRT DNPDSIVDKN ARVMELIAAY RNRGHLMADI 430 440 450 460 470 480 DPLRLDNTRF RSHPDLDLLT HGLTLWDLDR VFKVNGFGGW KYKKLRDVLG LLRDAYCRHI 490 500 510 520 530 540 GVEYTHILDP EQQEWLQQRV ETKNVKPTVA EQKYILSKLN AAEAFETFLH TKYVGQKRFS 550 560 570 580 590 600 LEGAESVIPM MDAAIDQCAK HGLDEVVIGM PHRGRLNVLA NIVGKPYSQI FTEFEGNLNP 610 620 630 640 650 660 TLAHSSGDVK YHLGATGLYL QMFGDNDIQV SLTANPSHLE AVDPVLEGLV RAKQDLLNKD 670 680 690 700 710 720 TNGNQDEAFS VVPMMLHGDA AFAGQGVVAE TLNLANLPGY RVGGTIHIIV NNQIGFTTAP 730 740 750 760 770 780 EYSRSSEYCT DVAKMIGAPI FHVNGDDPEA CVWVAKLAVD FRQRFKKDVV IDMLCYRRRG 790 800 810 820 830 840 HNEGDDPSMT NPYMYDVVDT KRGARKSYTE ALIGRGDISL KEAEDALRDY QGQLERVFNE 850 860 870 880 890 900 VRDLEKHGVQ PSESVESDQM IPAGLSTAVD KALLARIGDA FLAVPEGFTV HPRVQPVLEK 910 920 930 940 950 960 RREMAYEGKI DWAFAELLAL GSLVAEGKLV RLSGQDTKRG TFSQRHSVII DRHTGEEFTP 970 980 990 1000 1010 1020 LQLLANNPDG SPTGGKFLVY NSPLSEYAAV GFEYGYTVGN PDAVVLWEAQ FGDFVNGAQS 1030 1040 1050 1060 1070 1080 IIDEFINSGE AKWGQLSTVV LLLPHGHEGQ GPDHTSGRIE RFLQLWAEGS MTFAVPSTPS 1090 1100 1110 1120 1130 1140 NYFHLLRRHA LDGIKRPLIV FTPKSMLRNK AAVSDIKDFT EIKFRSVLEE PTYEDSIDDR 1150 1160 1170 1180 1190 1200 SKVTRVLLTC GKLYYELAAR KIKDNRDDVA IVRIEQLAPL PRRRLGETLD RYENAKEFFW 1210 1220 1230 1240 1250 1260 VQEEPANQGA WPRFGLELPE LLPRLTGIKR ISRRAMSAPS SGSSKVHAVE QQEILDTAFG

References

[1]

"Comparative genomic and phylogeographic analysis of Mycobacterium leprae." Monot M., Honore N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L. , Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T. Nat. Genet. 41:1282-1289(2009) [PubMed: 19881526] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211192 Genomic DNA. Translation: CAR71190.1.
RefSeq	YP_002503432.1. NC_011896.1.
3D structure databases
ProteinModelPortal	B8ZR05.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZR05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000085237; EBMYCP00000082259; EBMYCG00000086371.
GeneID	7326561.
GenomeReviews	Gene locus MLBr01095 in contig FM211192_GR.
PATRIC	18043469. VBIMycLep121698_1965.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000014858.
HOGENOM	HBG289950.
OMA	EGDEPAF.
ProtClustDB	PRK12270.
Family and domain databases
InterPro	IPR001078. 2-oxoacid_DH_actylTfrase. IPR011603. 2oxoglutarate_DH_E1. IPR023213. CAT-like_dom. IPR001017. DH_E1. IPR005475. Transketolase-like_Pyr-bd. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit.
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8ZR05_MYCLB

Accession

Primary (citable) accession number: B8ZR05

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)