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B8ZR02 (B8ZR02_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP MF_01517 RuleBase RU000422
EC=1.1.1.37 HAMAP MF_01517 RuleBase RU000422
Gene names
Name:mdh HAMAP MF_01517 EMBL CAR71186.1
Ordered Locus Names:MLBr01091
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517 SAAS SAAS001252

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 RuleBase RU000422 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP MF_01517 RuleBase RU000421

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP MF_01517
Binding site931Substrate By similarity HAMAP MF_01517
Binding site991Substrate By similarity HAMAP MF_01517
Binding site1061NAD By similarity HAMAP MF_01517
Binding site1131NAD By similarity HAMAP MF_01517
Binding site1321Substrate By similarity HAMAP MF_01517
Binding site1631Substrate By similarity HAMAP MF_01517

Sequences

Sequence LengthMass (Da)Tools
B8ZR02 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 77FF1F9F62307ABB

FASTA32934,487
        10         20         30         40         50         60 
MSPRPLKVAV TGAAGQIGYS LLFRLASGSL LGLDRPIELR LLEIEPALKA LEGVVMELDD 

        70         80         90        100        110        120 
CAFLLLAGVE IGADPNKVFD GVNLALLVGA RPRGPGMERG DLLEANGAIF TAQGKALNAV 

       130        140        150        160        170        180 
AAADIRVGVT GNPANTNALI AMTNAPDIPR ERFSALTRLD HNRAIAQLAT KTGSAVTDIR 

       190        200        210        220        230        240 
KMTIWGNHSA TQYPDVFHAE IGGKNAAEVV GDQAWIEDYF IPTVAKRGAA IIDARGASSA 

       250        260        270        280        290        300 
ASAASATIDA ARDWLLGTPE GNWVSMAVVS DGSYGVPEGL ISSFPVTTTD GDWTIVRGLG 

       310        320 
IDDFSRGRID KSTAELADER MAVKQLGLI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71186.1.
RefSeqYP_002503429.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZR02.
SMRB8ZR02. Positions 5-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZR02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085380; EBMYCP00000082195; EBMYCG00000087588.
GeneID7326558.
GenomeReviewsGene locus MLBr01091 in contig FM211192_GR.
PATRIC18043449. VBIMycLep121698_1954.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000018111.
HOGENOMHBG289884.
OMANKIQISL.
ProtClustDBPRK05442.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8ZR02_MYCLB
AccessionPrimary (citable) accession number: B8ZR02
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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