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B8ZQX2 (DCUP_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:MLBr01043
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000197530

Regions

Region30 – 345Substrate binding By similarity

Sites

Binding site791Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3361Substrate By similarity
Site791Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
B8ZQX2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 07DA9ED448BE9FF2

FASTA35738,211
        10         20         30         40         50         60 
MSTRRELLES PYLAAVSGRK PCRVPVWFMR QAGRSLPEYR ALRERYSMLA ACFEPEVACE 

        70         80         90        100        110        120 
ITLQPLRRYD VDAAILFSDI VVPLCAAGID LDIVPDVGPV IGDPVRTATD IHAMKPLEPQ 

       130        140        150        160        170        180 
AIQPIFQAIS LLVAALGDVP LIGFAGAPFT LASYLVEGGP SRNHPRTKAM MLAEPASWHT 

       190        200        210        220        230        240 
LMDKLTDLTL GFLLGQIDAG VDAIQVFDSW AGTLSLSDYR QYVLPHSARI FATVAEHGVP 

       250        260        270        280        290        300 
MTHFGVGTAD LLGAMSAAVR SGEKPGHQAV VGVDWRTSLT DAAARVEPCT ALQGNLDPVV 

       310        320        330        340        350 
LLAGWPAVER VARTVVDDGR RAVVAGAAGH VFNLGHGVLP ETDPGVLSEL VSFIHSL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71138.1.
RefSeqYP_002503399.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZQX2.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZQX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085504; EBMYCP00000081750; EBMYCG00000085373.
GeneID7326521.
GenomeReviewsGene locus MLBr01043 in contig FM211192_GR.
PATRIC18043298. VBIMycLep121698_1879.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016469.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_MYCLB
AccessionPrimary (citable) accession number: B8ZQX2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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