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B8ZQW9 (DXS_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:MLBr01038
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6436431-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_1000132941

Sequences

Sequence LengthMass (Da)Tools
B8ZQW9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 2C86C884ABCAA00B

FASTA64368,863
        10         20         30         40         50         60 
MLEQIRRPAD LQHLSQQQLR DLAAEIRELL VHKVAATGGH LGPNLGVVEL TLALHRVFDS 

        70         80         90        100        110        120 
PHDPIIFDTG HQAYVHKMLT GRCQDFDSLR KKAGLSGYPS RAESEHDWVE SSHASTALSY 

       130        140        150        160        170        180 
ADGLAKAFEL AGNRNRHVVA VVGDGALTGG MCWEALNNIA ATPRPVVIVV NDNGRSYAPT 

       190        200        210        220        230        240 
IGGVADHLAT LRLQPAYERL LEKGRDALHS LPLIGQIAYR FMHSVKAGIK DSLSPQLLFT 

       250        260        270        280        290        300 
DLGLKYVGPV DGHDEHAVEV ALRKARGFGG PVIVHVVTRK GMGYPPAEAD QAEQMHTCGV 

       310        320        330        340        350        360 
MDPTTGQPTK IAAPDWTAIF SDALIGYAMK RRDIVAITAA MPGPTGLTAF GQCFPDRLFD 

       370        380        390        400        410        420 
VGIAEQHAMT SAAGLAMGRM HPVVAIYSTF LNRAFDQIMM DVALHKLPVT MVIDRAGITG 

       430        440        450        460        470        480 
SDGPSHNGMW DLSMLGIVPG MRVAAPRDAI RLREELGEAL DVDDGPTAIR FPKGDVCEDI 

       490        500        510        520        530        540 
PALKRRSGVD VLAVPATGLA QDVLLVGVGV FASMALAVAK RLHNQGIGVT VIDPRWVLPV 

       550        560        570        580        590        600 
CDGVLELAHT HKLIVTLEDN GVNGGVGAAV STALRQVEID TPCRDVGLPQ EFYDHASRSE 

       610        620        630        640 
VLADLGLTDQ DVARRITGWV VAFGHCGSGD DAGQYGPRSS QTM

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71133.1.
RefSeqYP_002503396.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZQW9.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZQW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000086145; EBMYCP00000081415; EBMYCG00000086587.
GeneID7326762.
GenomeReviewsGene locus MLBr01038 in contig FM211192_GR.
PATRIC18043286. VBIMycLep121698_1873.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016269.
HOGENOMHBG571647.
OMAQYDISYM.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_MYCLB
AccessionPrimary (citable) accession number: B8ZQW9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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