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B8ZQS6 (B8ZQS6_MYCLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172 EMBL CAR71056.1
Ordered Locus Names:MLBr00961
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6471Zinc By similarity HAMAP MF_00172
Metal binding6491Zinc By similarity HAMAP MF_00172
Metal binding7321Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
B8ZQS6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 1E92FA570B9ACC97

FASTA76082,235
        10         20         30         40         50         60 
MDELVTTQSF TATVTGSPRI GPRRELKRAT EGYWAKRTSR SELESVASTL RRDMWSDLAA 

        70         80         90        100        110        120 
AGLDSVPVNT FSYYDQMLDT AFMLGALPAR VAQVSDDLDQ YFALARGNND IKPLEMTKWF 

       130        140        150        160        170        180 
DTNYHYLVPE IEPATTFSLN PGKILGELKE ALEQRIPSRP VIIGPVTFLL LSKGINGGGA 

       190        200        210        220        230        240 
PIQRLEELVG IYCTLLSLLA ENGARWVQFD EPALVTDLSP DAPALAEAVY TALGSVSKRP 

       250        260        270        280        290        300 
AIYVATYFGN PGASLAGLAR TPIEAIGVDF VCGADTSVAA VPELAGKTLV AGIVDGRNIW 

       310        320        330        340        350        360 
RTDLESALSK LATLLGSAAT VAVSTSCSTL HVPYSLEPET DLDDNLRSWL AFGAEKVAEV 

       370        380        390        400        410        420 
VVLARALRDG RDAVADEIAA SNAAVASRRS DPRLHNGQVR ARIDSIVASG THRGDAAQRR 

       430        440        450        460        470        480 
TSQDARLHLP PLPTTTIGSY PQTSAIRKAR AALQDAEIDE AEYISRMKKE VADAIKLQEQ 

       490        500        510        520        530        540 
LGLDVLVHGE PERNDMVQYF AEQLGGFFAT QNGWVQSYGS RCVRPPILYG DVSRPHPMTI 

       550        560        570        580        590        600 
EWITYAQSLT DKPVKGMLTG PVTILAWSFV RDDQPLADTA NQVALAIRDE TVDLQSAGIA 

       610        620        630        640        650        660 
IIQVDEPALR ELLPLRRADQ DEYLCWAVKA FRLATSGVAD STQIHTHLCY SEFGEVIGAI 

       670        680        690        700        710        720 
ADLDADVTSI EAARSHMEVL DDLNAVGFAN SIGPGVYDIH SPRVPSTDEI AKSLRAALKA 

       730        740        750        760 
IPMQRLWVNP DCGLKTRSVD EVSASLQNMV AAARQVRAGA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM211192 Genomic DNA. Translation: CAR71056.1.
RefSeqYP_002503353.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZQS6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8ZQS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000085915; EBMYCP00000082856; EBMYCG00000085611.
GeneID7326696.
GenomeReviewsGene locus MLBr00961 in contig FM211192_GR.
PATRIC18043030. VBIMycLep121698_1745.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017657.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8ZQS6_MYCLB
AccessionPrimary (citable) accession number: B8ZQS6
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info