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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:MLBr00911
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000006900 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei55 – 75HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei187 – 207HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21
Transmembranei334 – 354HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001171881 – 359Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST359

Structurei

3D structure databases

SMRiB8ZQP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZQP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQILVAVTV ALVVSILLTP ALIRLFTRHG FGQEIREDGP PSHHNKRGTP
60 70 80 90 100
SMGGVAIVAG IWAGYLGTHL AGLAFDGEGV SASGVLVLGL ATALGGVGFL
110 120 130 140 150
DDLIKIRRSR NLGLNKTAKT VGQITAAVLF GVLVLQFRNG AGLTPASADL
160 170 180 190 200
SYVREIATVT LAPALFVLFC MVIVSAWSNA VNFTDGLDGL AAGSMAMVTA
210 220 230 240 250
AYVLITFWQY RNACVTAPGL GCYNVRDPLD LTLIAAATVG ACIGFLWWNA
260 270 280 290 300
APAKVFMGDT GSLALGGVIA GLSVTSRTEI LAVVLGSLFV AEITSVVLQI
310 320 330 340 350
LAFRTTGRRV FRMAPFHHHF ELAGWAETTV IIRFWLLTAI ACGLGVVLFY

GEWLATIGA
Length:359
Mass (Da):37,759
Last modified:March 3, 2009 - v1
Checksum:i0C64C018C8B175BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR71006.1.
RefSeqiWP_012634423.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR71006; CAR71006; MLBr00911.
KEGGimlb:MLBr00911.

Similar proteinsi

Entry informationi

Entry nameiMRAY_MYCLB
AccessioniPrimary (citable) accession number: B8ZQP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 7, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families