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B8ZQK6

- GCST_MYCLB

UniProt

B8ZQK6 - GCST_MYCLB

Protein

Aminomethyltransferase

Gene

gcvT

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

    Catalytic activityi

    [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

    GO - Molecular functioni

    1. aminomethyltransferase activity Source: UniProtKB-EC
    2. transaminase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciMLEP561304:GJP6-882-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
    Alternative name(s):
    Glycine cleavage system T proteinUniRule annotation
    Gene namesi
    Name:gcvTUniRule annotation
    Ordered Locus Names:MLBr00865
    OrganismiMycobacterium leprae (strain Br4923)
    Taxonomic identifieri561304 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000006900: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367AminomethyltransferasePRO_1000125643Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi561304.MLBr_00865.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZQK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0404.
    KOiK00605.
    OMAiPFVEINT.
    OrthoDBiEOG6T1WS5.

    Family and domain databases

    Gene3Di2.40.30.110. 1 hit.
    3.30.1360.120. 2 hits.
    HAMAPiMF_00259. GcvT.
    InterProiIPR006223. GCS_T.
    IPR022903. GCS_T_bac.
    IPR028896. GCST/DmdA.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view]
    PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
    PfamiPF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006487. GcvT. 1 hit.
    SUPFAMiSSF101790. SSF101790. 1 hit.
    TIGRFAMsiTIGR00528. gcvT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8ZQK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDAPELLKG PLEDRHRELG ANFAEFGGWL MPVSYAGTVS EHSATRNAVG    50
    LFDVSHLGKA LVRGPGAAQF VNSVLTNDLG RIRPGKAQYT LCCSESGGVI 100
    DDLIAYYVDD DEIFLVSNAA NTAAVVDALQ AVVPAGLTII NQHRSHAVLA 150
    VQGPRSTDVL GELGLPTGID YMGYVDASYA GVPVRVCRTG YTGEQGYELL 200
    PPWESADVVF DALVAAVVDA RGEPAGLGAR DTLRTEMGYP LYGHELSLDI 250
    SPLQARCGWA IGWKKDAFLG RDALLAEKAA GPRRLLRGLR MAGRGVLRPG 300
    LTVCAGDIPI GVTTSGTFSP TLQVGVALAL IDSEAAVQDG QQIIVDVRGR 350
    AVECEVVRPP FIEVKTR 367
    Length:367
    Mass (Da):38,879
    Last modified:March 3, 2009 - v1
    Checksum:iB0B40CEFF6A6A094
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70960.1.
    RefSeqiWP_010907977.1. NC_011896.1.
    YP_002503283.1. NC_011896.1.

    Genome annotation databases

    EnsemblBacteriaiCAR70960; CAR70960; MLBr00865.
    GeneIDi7327372.
    KEGGimlb:MLBr_00865.
    PATRICi18042730. VBIMycLep121698_1595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211192 Genomic DNA. Translation: CAR70960.1 .
    RefSeqi WP_010907977.1. NC_011896.1.
    YP_002503283.1. NC_011896.1.

    3D structure databases

    ProteinModelPortali B8ZQK6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561304.MLBr_00865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR70960 ; CAR70960 ; MLBr00865 .
    GeneIDi 7327372.
    KEGGi mlb:MLBr_00865.
    PATRICi 18042730. VBIMycLep121698_1595.

    Phylogenomic databases

    eggNOGi COG0404.
    KOi K00605.
    OMAi PFVEINT.
    OrthoDBi EOG6T1WS5.

    Enzyme and pathway databases

    BioCyci MLEP561304:GJP6-882-MONOMER.

    Family and domain databases

    Gene3Di 2.40.30.110. 1 hit.
    3.30.1360.120. 2 hits.
    HAMAPi MF_00259. GcvT.
    InterProi IPR006223. GCS_T.
    IPR022903. GCS_T_bac.
    IPR028896. GCST/DmdA.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view ]
    PANTHERi PTHR13847:SF5. PTHR13847:SF5. 1 hit.
    Pfami PF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006487. GcvT. 1 hit.
    SUPFAMi SSF101790. SSF101790. 1 hit.
    TIGRFAMsi TIGR00528. gcvT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Br4923.

    Entry informationi

    Entry nameiGCST_MYCLB
    AccessioniPrimary (citable) accession number: B8ZQK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3