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B8ZQK6

- GCST_MYCLB

UniProt

B8ZQK6 - GCST_MYCLB

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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

  1. aminomethyltransferase activity Source: UniProtKB-EC
  2. transaminase activity Source: UniProtKB-KW

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:MLBr00865
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367AminomethyltransferasePRO_1000125643Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi561304.MLBr_00865.

Structurei

3D structure databases

ProteinModelPortaliB8ZQK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0404.
KOiK00605.
OMAiPFVEINT.
OrthoDBiEOG6T1WS5.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZQK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDAPELLKG PLEDRHRELG ANFAEFGGWL MPVSYAGTVS EHSATRNAVG
60 70 80 90 100
LFDVSHLGKA LVRGPGAAQF VNSVLTNDLG RIRPGKAQYT LCCSESGGVI
110 120 130 140 150
DDLIAYYVDD DEIFLVSNAA NTAAVVDALQ AVVPAGLTII NQHRSHAVLA
160 170 180 190 200
VQGPRSTDVL GELGLPTGID YMGYVDASYA GVPVRVCRTG YTGEQGYELL
210 220 230 240 250
PPWESADVVF DALVAAVVDA RGEPAGLGAR DTLRTEMGYP LYGHELSLDI
260 270 280 290 300
SPLQARCGWA IGWKKDAFLG RDALLAEKAA GPRRLLRGLR MAGRGVLRPG
310 320 330 340 350
LTVCAGDIPI GVTTSGTFSP TLQVGVALAL IDSEAAVQDG QQIIVDVRGR
360
AVECEVVRPP FIEVKTR
Length:367
Mass (Da):38,879
Last modified:March 3, 2009 - v1
Checksum:iB0B40CEFF6A6A094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR70960.1.
RefSeqiWP_010907977.1. NC_011896.1.
YP_002503283.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70960; CAR70960; MLBr00865.
GeneIDi7327372.
KEGGimlb:MLBr_00865.
PATRICi18042730. VBIMycLep121698_1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR70960.1 .
RefSeqi WP_010907977.1. NC_011896.1.
YP_002503283.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZQK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_00865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR70960 ; CAR70960 ; MLBr00865 .
GeneIDi 7327372.
KEGGi mlb:MLBr_00865.
PATRICi 18042730. VBIMycLep121698_1595.

Phylogenomic databases

eggNOGi COG0404.
KOi K00605.
OMAi PFVEINT.
OrthoDBi EOG6T1WS5.

Enzyme and pathway databases

BioCyci MLEP561304:GJP6-882-MONOMER.

Family and domain databases

Gene3Di 2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPi MF_00259. GcvT.
InterProi IPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view ]
PANTHERi PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfami PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006487. GcvT. 1 hit.
SUPFAMi SSF101790. SSF101790. 1 hit.
TIGRFAMsi TIGR00528. gcvT. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiGCST_MYCLB
AccessioniPrimary (citable) accession number: B8ZQK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3