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B8ZQK6 (GCST_MYCLB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminomethyltransferase

EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:MLBr00865
OrganismMycobacterium leprae (strain Br4923) [Complete proteome] [HAMAP]
Taxonomic identifier561304 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP-Rule MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP-Rule MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminomethyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Aminomethyltransferase HAMAP-Rule MF_00259
PRO_1000125643

Sequences

Sequence LengthMass (Da)Tools
B8ZQK6 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: B0B40CEFF6A6A094

FASTA36738,879
        10         20         30         40         50         60 
MTDAPELLKG PLEDRHRELG ANFAEFGGWL MPVSYAGTVS EHSATRNAVG LFDVSHLGKA 

        70         80         90        100        110        120 
LVRGPGAAQF VNSVLTNDLG RIRPGKAQYT LCCSESGGVI DDLIAYYVDD DEIFLVSNAA 

       130        140        150        160        170        180 
NTAAVVDALQ AVVPAGLTII NQHRSHAVLA VQGPRSTDVL GELGLPTGID YMGYVDASYA 

       190        200        210        220        230        240 
GVPVRVCRTG YTGEQGYELL PPWESADVVF DALVAAVVDA RGEPAGLGAR DTLRTEMGYP 

       250        260        270        280        290        300 
LYGHELSLDI SPLQARCGWA IGWKKDAFLG RDALLAEKAA GPRRLLRGLR MAGRGVLRPG 

       310        320        330        340        350        360 
LTVCAGDIPI GVTTSGTFSP TLQVGVALAL IDSEAAVQDG QQIIVDVRGR AVECEVVRPP 


FIEVKTR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM211192 Genomic DNA. Translation: CAR70960.1.
RefSeqYP_002503283.1. NC_011896.1.

3D structure databases

ProteinModelPortalB8ZQK6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561304.MLBr_00865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR70960; CAR70960; MLBr00865.
GeneID7327372.
KEGGmlb:MLBr_00865.
PATRIC18042730. VBIMycLep121698_1595.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
KOK00605.
OMAPFVEINT.
OrthoDBEOG6T1WS5.

Enzyme and pathway databases

BioCycMLEP561304:GJP6-882-MONOMER.

Family and domain databases

Gene3D2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPMF_00259. GcvT.
InterProIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
SUPFAMSSF101790. SSF101790. 1 hit.
TIGRFAMsTIGR00528. gcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_MYCLB
AccessionPrimary (citable) accession number: B8ZQK6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families