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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:MLBr00865
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367AminomethyltransferasePRO_1000125643Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8ZQK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0404.
KOiK00605.
OMAiKEQDIAH.
OrthoDBiEOG6T1WS5.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZQK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAPELLKG PLEDRHRELG ANFAEFGGWL MPVSYAGTVS EHSATRNAVG
60 70 80 90 100
LFDVSHLGKA LVRGPGAAQF VNSVLTNDLG RIRPGKAQYT LCCSESGGVI
110 120 130 140 150
DDLIAYYVDD DEIFLVSNAA NTAAVVDALQ AVVPAGLTII NQHRSHAVLA
160 170 180 190 200
VQGPRSTDVL GELGLPTGID YMGYVDASYA GVPVRVCRTG YTGEQGYELL
210 220 230 240 250
PPWESADVVF DALVAAVVDA RGEPAGLGAR DTLRTEMGYP LYGHELSLDI
260 270 280 290 300
SPLQARCGWA IGWKKDAFLG RDALLAEKAA GPRRLLRGLR MAGRGVLRPG
310 320 330 340 350
LTVCAGDIPI GVTTSGTFSP TLQVGVALAL IDSEAAVQDG QQIIVDVRGR
360
AVECEVVRPP FIEVKTR
Length:367
Mass (Da):38,879
Last modified:March 3, 2009 - v1
Checksum:iB0B40CEFF6A6A094
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR70960.1.
RefSeqiWP_010907977.1. NC_011896.1.
YP_002503283.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70960; CAR70960; MLBr00865.
KEGGimlb:MLBr_00865.
PATRICi18042730. VBIMycLep121698_1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211192 Genomic DNA. Translation: CAR70960.1.
RefSeqiWP_010907977.1. NC_011896.1.
YP_002503283.1. NC_011896.1.

3D structure databases

ProteinModelPortaliB8ZQK6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR70960; CAR70960; MLBr00865.
KEGGimlb:MLBr_00865.
PATRICi18042730. VBIMycLep121698_1595.

Phylogenomic databases

eggNOGiCOG0404.
KOiK00605.
OMAiKEQDIAH.
OrthoDBiEOG6T1WS5.

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-882-MONOMER.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiGCST_MYCLB
AccessioniPrimary (citable) accession number: B8ZQK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.