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B8ZQJ6

- PNP_MYCLB

UniProt

B8ZQJ6 - PNP_MYCLB

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, MLBr00854
Organism
Mycobacterium leprae (strain Br4923)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi532 – 5321Magnesium By similarity
Metal bindingi538 – 5381Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMLEP561304:GJP6-871-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:MLBr00854
OrganismiMycobacterium leprae (strain Br4923)
Taxonomic identifieri561304 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000006900: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_1000185747Add
BLAST

Proteomic databases

PRIDEiB8ZQJ6.

Interactioni

Protein-protein interaction databases

STRINGi561304.MLBr_00854.

Structurei

3D structure databases

ProteinModelPortaliB8ZQJ6.
SMRiB8ZQJ6. Positions 13-732.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini598 – 65760KHAdd
BLAST
Domaini669 – 73870S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZQJ6-1 [UniParc]FASTAAdd to Basket

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MSVAEIEEGV FEATVTIDNG SFGTRAIRFE TGRLALQAAG AVVAYLDADN    50
MLLSATTASK NPKEQFDFFP LTVDVEERMY AAGRIPGSFF RREGRPSTDA 100
ILTCRLIDRP LRPSFVDGLR NEIQVVVTIL SVDPNDLYDV LAINAASAST 150
QLGGLPFSGP IGGVRVALID GTWVAFPTVE QLERAVFDMV IAGRIVGTDD 200
EGKPDVAIMM VEAEATENVI ELVECGAQAP TESIVAQGLE VAKPFIAALC 250
TAQQELADVV SSRQAKPPVE YPTFPDYGDD VYYSVASMAT DELAAALTIG 300
AKLERDQRTN EIKTQVLERL AGTYEGREKE LGAAFRSLTK KLVRQRILTN 350
HFRIDGRGIT DIRALSAEVA VVPRAHGSAL FERGETQILG VTTLDMVKMA 400
QQIDSLGPET SKRYMHHYNF PPFSTGETGR VGSPKRREIG HGALAERALV 450
PVLPSVEEFP YAIRQVSEAL GSNGSTSMGS VCASTLALLN AGVPLKAPVA 500
GIAMGLVSDD VEFDGGTERR FVTLTDILGA EDAFGDMDFK CAGTKDFVTA 550
LQLDTKLDGI PSQVLAGALA QAKDARLTIL EVMAEAIDRP DEMSPYAPRV 600
ITIKVPVDKI GEVIGPKGKV INAITEETGA QISIEDDGTV FVGATDGLSA 650
QAAINKINAI ANPQLPTVGE RFLGTVVKIT EFGAFVSLLP GRDGLVHISK 700
LGKGKRIAKV EDVVNVGDKL RVEIADIEKR GKISLVLVAD DDSATVPAAP 750
ADAGAAQEFG SGTAPADAAT ASS 773
Length:773
Mass (Da):82,047
Last modified:March 3, 2009 - v1
Checksum:i25B9790BF6125D73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70949.1.
RefSeqiWP_010907967.1. NC_011896.1.
YP_002503273.1. NC_011896.1.

Genome annotation databases

EnsemblBacteriaiCAR70949; CAR70949; MLBr00854.
GeneIDi7325955.
KEGGimlb:MLBr_00854.
PATRICi18042702. VBIMycLep121698_1581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211192 Genomic DNA. Translation: CAR70949.1 .
RefSeqi WP_010907967.1. NC_011896.1.
YP_002503273.1. NC_011896.1.

3D structure databases

ProteinModelPortali B8ZQJ6.
SMRi B8ZQJ6. Positions 13-732.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561304.MLBr_00854.

Proteomic databases

PRIDEi B8ZQJ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR70949 ; CAR70949 ; MLBr00854 .
GeneIDi 7325955.
KEGGi mlb:MLBr_00854.
PATRICi 18042702. VBIMycLep121698_1581.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MLEP561304:GJP6-871-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Br4923.

Entry informationi

Entry nameiPNP_MYCLB
AccessioniPrimary (citable) accession number: B8ZQJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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