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B8ZQ59

- LACG_STRPJ

UniProt

B8ZQ59 - LACG_STRPJ

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Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei375 – 3751NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-1053-MONOMER.
UniPathwayiUPA00542; UER00605.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
Ordered Locus Names:SPN23F10850
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phospho-beta-galactosidasePRO_1000185575Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561276.SPN23F_10850.

Structurei

3D structure databases

ProteinModelPortaliB8ZQ59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2723.
KOiK01220.
OMAiIGRREAP.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZQ59 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS
60 70 80 90 100
DFYNRYPVDL KLAEEYGVNG IRISIAWSRI FPTGYGQVNV KGVEFYHNLF
110 120 130 140 150
AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRENIEHFVD YAAFCFEEFP
160 170 180 190 200
EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV
210 220 230 240 250
KLYKEKGYKG EIGVVHALPT KYPLDHENPA DVRAAELEDI IHNKFILDAT
260 270 280 290 300
YLGHYSEKTL AGVEAILAAN GGSLDLREED FTALEAAKDL NDFLGINYYM
310 320 330 340 350
SDWMEAFDGE TEIIHNGKGE KGSSKYQIKG IGRRVAPDYV PRTDWDWIIY
360 370 380 390 400
PQGLYDQIMR VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ
410 420 430 440 450
HLEVLSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFETQERY
460
PKKSAHWYKK VAETQIID
Length:468
Mass (Da):53,837
Last modified:March 3, 2009 - v1
Checksum:i7205F2127CC5F0DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR68898.1.
RefSeqiYP_002511044.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR68898; CAR68898; SPN23F10850.
GeneIDi7328098.
KEGGisne:SPN23F_10850.
PATRICi19673498. VBIStrPne132160_1152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR68898.1 .
RefSeqi YP_002511044.1. NC_011900.1.

3D structure databases

ProteinModelPortali B8ZQ59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_10850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR68898 ; CAR68898 ; SPN23F10850 .
GeneIDi 7328098.
KEGGi sne:SPN23F_10850.
PATRICi 19673498. VBIStrPne132160_1152.

Phylogenomic databases

eggNOGi COG2723.
KOi K01220.
OMAi IGRREAP.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SPNE561276:GJFJ-1053-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiLACG_STRPJ
AccessioniPrimary (citable) accession number: B8ZQ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3