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Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi: lactose degradation

This protein is involved in step 1 of the subpathway that synthesizes D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-phospho-beta-galactosidase (lacG)
This subpathway is part of the pathway lactose degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate, the pathway lactose degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei160Proton donorUniRule annotation1
Active sitei375NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE561276:G1GII-1422-MONOMER
UniPathwayiUPA00542; UER00605

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
Ordered Locus Names:SPN23F10850
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001855751 – 4686-phospho-beta-galactosidaseAdd BLAST468

Proteomic databases

PRIDEiB8ZQ59

Structurei

3D structure databases

ProteinModelPortaliB8ZQ59
SMRiB8ZQ59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

KOiK01220
OMAiIHREYNA

Family and domain databases

HAMAPiMF_01574 LacG, 1 hit
InterProiView protein in InterPro
IPR005928 6P-beta-galactosidase
IPR001360 Glyco_hydro_1
IPR018120 Glyco_hydro_1_AS
IPR033132 Glyco_hydro_1_N_CS
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR01233 lacG, 1 hit
PROSITEiView protein in PROSITE
PS00572 GLYCOSYL_HYDROL_F1_1, 1 hit
PS00653 GLYCOSYL_HYDROL_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8ZQ59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS
60 70 80 90 100
DFYNRYPVDL KLAEEYGVNG IRISIAWSRI FPTGYGQVNV KGVEFYHNLF
110 120 130 140 150
AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRENIEHFVD YAAFCFEEFP
160 170 180 190 200
EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV
210 220 230 240 250
KLYKEKGYKG EIGVVHALPT KYPLDHENPA DVRAAELEDI IHNKFILDAT
260 270 280 290 300
YLGHYSEKTL AGVEAILAAN GGSLDLREED FTALEAAKDL NDFLGINYYM
310 320 330 340 350
SDWMEAFDGE TEIIHNGKGE KGSSKYQIKG IGRRVAPDYV PRTDWDWIIY
360 370 380 390 400
PQGLYDQIMR VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ
410 420 430 440 450
HLEVLSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFETQERY
460
PKKSAHWYKK VAETQIID
Length:468
Mass (Da):53,837
Last modified:March 3, 2009 - v1
Checksum:i7205F2127CC5F0DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA Translation: CAR68898.1
RefSeqiWP_000169288.1, NC_011900.1

Genome annotation databases

EnsemblBacteriaiCAR68898; CAR68898; SPN23F10850
KEGGisne:SPN23F10850

Similar proteinsi

Entry informationi

Entry nameiLACG_STRPJ
AccessioniPrimary (citable) accession number: B8ZQ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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