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B8ZPZ6

- FUCI_STRPJ

UniProt

B8ZPZ6 - FUCI_STRPJ

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Protein
L-fucose isomerase
Gene
fucI, SPN23F21900
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei335 – 3351Proton acceptor By similarity
Metal bindingi335 – 3351Manganese By similarity
Active sitei359 – 3591Proton acceptor By similarity
Metal bindingi359 – 3591Manganese By similarity
Metal bindingi525 – 5251Manganese By similarity

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-2140-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomerase (EC:5.3.1.25)
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene namesi
Name:fucI
Ordered Locus Names:SPN23F21900
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588L-fucose isomeraseUniRule annotation
PRO_1000165098Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561276.SPN23F_21900.

Structurei

3D structure databases

ProteinModelPortaliB8ZPZ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2407.
KOiK01818.
OMAiYWSPESV.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZPZ6-1 [UniParc]FASTAAdd to Basket

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MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP    50
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD 100
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEANDTDIP 150
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG 200
MRNESVDMTE FTRRMDRGIY DPEEFERAMV WVKEHIKEGV DRNREDLILS 250
KEEKEKQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 300
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL 350
TNTPQIFADV RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG 400
QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK 450
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW 500
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM 550
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK 588
Length:588
Mass (Da):65,890
Last modified:March 3, 2009 - v1
Checksum:iFA71F53E326CC52F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR69923.1.
RefSeqiYP_002512017.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR69923; CAR69923; SPN23F21900.
GeneIDi7328495.
KEGGisne:SPN23F_21900.
PATRICi19675898. VBIStrPne132160_2298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR69923.1 .
RefSeqi YP_002512017.1. NC_011900.1.

3D structure databases

ProteinModelPortali B8ZPZ6.
ModBasei Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_21900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR69923 ; CAR69923 ; SPN23F21900 .
GeneIDi 7328495.
KEGGi sne:SPN23F_21900.
PATRICi 19675898. VBIStrPne132160_2298.

Phylogenomic databases

eggNOGi COG2407.
KOi K01818.
OMAi YWSPESV.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci SPNE561276:GJFJ-2140-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiFUCI_STRPJ
AccessioniPrimary (citable) accession number: B8ZPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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