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B8ZMJ8

- FMT_STRPJ

UniProt

B8ZMJ8 - FMT_STRPJ

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Protein
Methionyl-tRNA formyltransferase
Gene
fmt, SPN23F17380
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Enzyme and pathway databases

    BioCyciSPNE561276:GJFJ-1665-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionyl-tRNA formyltransferase (EC:2.1.2.9)
    Gene namesi
    Name:fmt
    Ordered Locus Names:SPN23F17380
    OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
    Taxonomic identifieri561276 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002600: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Methionyl-tRNA formyltransferaseUniRule annotation
    PRO_1000190044Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561276.SPN23F_17380.

    Structurei

    3D structure databases

    ProteinModelPortaliB8ZMJ8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 1134Tetrahydrofolate (THF) binding By similarity

    Sequence similaritiesi

    Belongs to the Fmt family.

    Phylogenomic databases

    eggNOGiCOG0223.
    KOiK00604.
    OMAiKAQAQNE.
    OrthoDBiEOG6B09WV.

    Family and domain databases

    Gene3Di3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPiMF_00182. Formyl_trans.
    InterProiIPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view]
    PANTHERiPTHR11138. PTHR11138. 1 hit.
    PfamiPF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsiTIGR00460. fmt. 1 hit.
    PROSITEiPS00373. GART. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZMJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLIFMGTP DFSATVLKGL LTDDRYEILA VVTQPDRAVG RKKVIQETPV    50
    KQAAKEAGLS IYQPEKLSGS PEMEELMKLG ADGIVTAAFG QFLPSKLLDS 100
    MDFAVNVHAS LLPRHRGGAP IHYALIQGDE EAGVTIMEMV KEMDAGDMIS 150
    RRSIPITDED NVGTLFEKLA LVGRDLLLDT LPAYIAGDIK PEPQDTSQVT 200
    FSPNIKPEEE KLDWNKTNRQ LFNQIRGMNP WPVAHAFLKG DRFKIYEALP 250
    VEGQGNPGEI LSIGKKELIV ATAEGALSLK QVQPAGKPKM DIASFLNGVG 300
    RTLTVGERFG D 311
    Length:311
    Mass (Da):33,971
    Last modified:March 3, 2009 - v1
    Checksum:i96A9E4FE6FBF7316
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211187 Genomic DNA. Translation: CAR69505.1.
    RefSeqiYP_002511621.1. NC_011900.1.

    Genome annotation databases

    EnsemblBacteriaiCAR69505; CAR69505; SPN23F17380.
    GeneIDi7329512.
    KEGGisne:SPN23F_17380.
    PATRICi19674852. VBIStrPne132160_1828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211187 Genomic DNA. Translation: CAR69505.1 .
    RefSeqi YP_002511621.1. NC_011900.1.

    3D structure databases

    ProteinModelPortali B8ZMJ8.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 561276.SPN23F_17380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR69505 ; CAR69505 ; SPN23F17380 .
    GeneIDi 7329512.
    KEGGi sne:SPN23F_17380.
    PATRICi 19674852. VBIStrPne132160_1828.

    Phylogenomic databases

    eggNOGi COG0223.
    KOi K00604.
    OMAi KAQAQNE.
    OrthoDBi EOG6B09WV.

    Enzyme and pathway databases

    BioCyci SPNE561276:GJFJ-1665-MONOMER.

    Family and domain databases

    Gene3Di 3.10.25.10. 1 hit.
    3.40.50.170. 1 hit.
    HAMAPi MF_00182. Formyl_trans.
    InterProi IPR005794. Fmt.
    IPR005793. Formyl_trans_C.
    IPR002376. Formyl_transf_N.
    IPR011034. Formyl_transferase_C-like.
    IPR001555. GART_AS.
    IPR015518. Met_tRNA_Form_TA-like.
    [Graphical view ]
    PANTHERi PTHR11138. PTHR11138. 1 hit.
    Pfami PF02911. Formyl_trans_C. 1 hit.
    PF00551. Formyl_trans_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50486. SSF50486. 1 hit.
    SSF53328. SSF53328. 1 hit.
    TIGRFAMsi TIGR00460. fmt. 1 hit.
    PROSITEi PS00373. GART. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
      Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
      J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700669 / Spain 23F-1.

    Entry informationi

    Entry nameiFMT_STRPJ
    AccessioniPrimary (citable) accession number: B8ZMJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: June 11, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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