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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:SPN23F17380
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001900441 – 311Methionyl-tRNA formyltransferaseAdd BLAST311

Structurei

3D structure databases

ProteinModelPortaliB8ZMJ8
SMRiB8ZMJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B8ZMJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLIFMGTP DFSATVLKGL LTDDRYEILA VVTQPDRAVG RKKVIQETPV
60 70 80 90 100
KQAAKEAGLS IYQPEKLSGS PEMEELMKLG ADGIVTAAFG QFLPSKLLDS
110 120 130 140 150
MDFAVNVHAS LLPRHRGGAP IHYALIQGDE EAGVTIMEMV KEMDAGDMIS
160 170 180 190 200
RRSIPITDED NVGTLFEKLA LVGRDLLLDT LPAYIAGDIK PEPQDTSQVT
210 220 230 240 250
FSPNIKPEEE KLDWNKTNRQ LFNQIRGMNP WPVAHAFLKG DRFKIYEALP
260 270 280 290 300
VEGQGNPGEI LSIGKKELIV ATAEGALSLK QVQPAGKPKM DIASFLNGVG
310
RTLTVGERFG D
Length:311
Mass (Da):33,971
Last modified:March 3, 2009 - v1
Checksum:i96A9E4FE6FBF7316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA Translation: CAR69505.1
RefSeqiWP_000163704.1, NC_011900.1

Genome annotation databases

EnsemblBacteriaiCAR69505; CAR69505; SPN23F17380
KEGGisne:SPN23F17380

Similar proteinsi

Entry informationi

Entry nameiFMT_STRPJ
AccessioniPrimary (citable) accession number: B8ZMJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health