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B8ZMJ8

- FMT_STRPJ

UniProt

B8ZMJ8 - FMT_STRPJ

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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-1665-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:SPN23F17380
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Methionyl-tRNA formyltransferasePRO_1000190044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561276.SPN23F_17380.

Structurei

3D structure databases

ProteinModelPortaliB8ZMJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 1134Tetrahydrofolate (THF) bindingUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0223.
KOiK00604.
OMAiKAQAQNE.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZMJ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLIFMGTP DFSATVLKGL LTDDRYEILA VVTQPDRAVG RKKVIQETPV
60 70 80 90 100
KQAAKEAGLS IYQPEKLSGS PEMEELMKLG ADGIVTAAFG QFLPSKLLDS
110 120 130 140 150
MDFAVNVHAS LLPRHRGGAP IHYALIQGDE EAGVTIMEMV KEMDAGDMIS
160 170 180 190 200
RRSIPITDED NVGTLFEKLA LVGRDLLLDT LPAYIAGDIK PEPQDTSQVT
210 220 230 240 250
FSPNIKPEEE KLDWNKTNRQ LFNQIRGMNP WPVAHAFLKG DRFKIYEALP
260 270 280 290 300
VEGQGNPGEI LSIGKKELIV ATAEGALSLK QVQPAGKPKM DIASFLNGVG
310
RTLTVGERFG D
Length:311
Mass (Da):33,971
Last modified:March 3, 2009 - v1
Checksum:i96A9E4FE6FBF7316
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR69505.1.
RefSeqiYP_002511621.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR69505; CAR69505; SPN23F17380.
GeneIDi7329512.
KEGGisne:SPN23F_17380.
PATRICi19674852. VBIStrPne132160_1828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR69505.1 .
RefSeqi YP_002511621.1. NC_011900.1.

3D structure databases

ProteinModelPortali B8ZMJ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_17380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR69505 ; CAR69505 ; SPN23F17380 .
GeneIDi 7329512.
KEGGi sne:SPN23F_17380.
PATRICi 19674852. VBIStrPne132160_1828.

Phylogenomic databases

eggNOGi COG0223.
KOi K00604.
OMAi KAQAQNE.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci SPNE561276:GJFJ-1665-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
PROSITEi PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiFMT_STRPJ
AccessioniPrimary (citable) accession number: B8ZMJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3