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Protein
Submitted name:

Sialidase A (Neuraminidase A)

Gene

nanA

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-1624-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase A (Neuraminidase A)Imported
Gene namesi
Name:nanAImported
Ordered Locus Names:SPN23F16920Imported
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)Imported
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

Subcellular locationi

Secretedcell wall SAAS annotation; Peptidoglycan-anchor SAAS annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB8ZMF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZMF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSVQERKC RYSIRKLSVG AVSMIVGAVV FGTSPVLAQE GASEQPLANE
60 70 80 90 100
TQLSGESSTL TDTEKSQPSS ETELSGNKQE QERKDKQEEK IPRDYYARDL
110 120 130 140 150
ENVETVIEKE DVETNASNGQ RVDLSSELDK LKKLENATVH MEFKPDAKAP
160 170 180 190 200
AFYNLFSVSS ATKKDEYFTM AVYNNTATLE GRGSDGKQFY GNYNDAPLKV
210 220 230 240 250
KPGQWNSVTF TVEKPTPELP KGRVRLYVNG VLSRTSLKSG NFIKDMPDVT
260 270 280 290 300
HVQIGATKRA NNTVWGSNLQ IRNLTVYNRA LTPEEVQKRS QLFKRSDLEK
310 320 330 340 350
KLPEGAVLTE KTDIFESGRN GKPNKDGIKS YRIPALLKTD KGTLIAGADE
360 370 380 390 400
RRLHSSDWGD IGMVIRRSED NGKTWGDRVT ITNLRDNPKA FDPSIGSPVN
410 420 430 440 450
IDMVLVQDPE TKRIFSIYDM FPEGKGIFGM SSQKEEAYKK IDGKTYQILY
460 470 480 490 500
REGEKGAYTI RENGTVYTPD GKATDYRVVV DPVKPAYSDK GDLYKGNQLL
510 520 530 540 550
GNIYFTTNKT SPFRIAKDSY LWMSYSDDDG KTWSAPQDIT PMVKADWMKF
560 570 580 590 600
LGVGPGTGIV LRNGPHKGRI LIPVYTTNNV SHLNGSQSSR VIYSDDHGKT
610 620 630 640 650
WHAGEAVNDN RQVDGQKIHS STMNNKRAQN TESTVVQLNN GDVKLFMRGL
660 670 680 690 700
TGDLQVATSK DGGVTWEKDI KRYPQVKDVY VQMSAIHTMH NGKEYIILSN
710 720 730 740 750
AGGPNRENGM VHLARVEENG ELTWLKHNPI QKGEFAYNSL QELGNGEYGI
760 770 780 790 800
LYEHTEKGQN AYTLSFRKFN WEFLSKDLIS PTEAKVKRTR EMGKGEMGKG
810 820 830 840 850
VIGLEFDSEV LVNKAPTLQL ANGKTATFLT QYDSKTLLFA VDKEDIGQEI
860 870 880 890 900
IGIAKGSIES MHNLPVNLAG ARVPGGVNGS KAAVHEVPEF TGGVNGTEPA
910 920 930 940 950
VHEIAEYKGS DSLVTLTTKE DYTYKAPLAQ QALPETGNKE SDLLASLGLT
960
AFFLGLFTLG KKREQ
Length:965
Mass (Da):107,129
Last modified:March 3, 2009 - v1
Checksum:i41E44E5134C5283C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA. Translation: CAR69464.1.
RefSeqiWP_012636588.1. NC_011900.1.
YP_002511581.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR69464; CAR69464; SPN23F16920.
GeneIDi7329489.
KEGGisne:SPN23F_16920.
PATRICi19674756. VBIStrPne132160_1780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA. Translation: CAR69464.1.
RefSeqiWP_012636588.1. NC_011900.1.
YP_002511581.1. NC_011900.1.

3D structure databases

ProteinModelPortaliB8ZMF7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR69464; CAR69464; SPN23F16920.
GeneIDi7329489.
KEGGisne:SPN23F_16920.
PATRICi19674756. VBIStrPne132160_1780.

Phylogenomic databases

eggNOGiCOG4409.
KOiK01186.
OMAiGGPKREN.
OrthoDBiEOG61CM2G.

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-1624-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR001791. Laminin_G.
IPR019931. LPXTG_anchor.
IPR026856. Sialidase_fam.
IPR011040. Sialidases.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF02973. Sialidase. 1 hit.
PF04650. YSIRK_signal. 1 hit.
[Graphical view]
SMARTiSM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1Imported.

Entry informationi

Entry nameiB8ZMF7_STRPJ
AccessioniPrimary (citable) accession number: B8ZMF7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.