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B8ZLK0

- GATB_STRPJ

UniProt

B8ZLK0 - GATB_STRPJ

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Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

Gene

gatB

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).UniRule annotation

Catalytic activityi

ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation
ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-403-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BUniRule annotation (EC:6.3.5.-UniRule annotation)
Short name:
Asp/Glu-ADT subunit BUniRule annotation
Gene namesi
Name:gatBUniRule annotation
Ordered Locus Names:SPN23F04090
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BPRO_1000122537Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of A, B and C subunits.UniRule annotation

Protein-protein interaction databases

STRINGi561276.SPN23F_04090.

Family & Domainsi

Sequence similaritiesi

Belongs to the GatB/GatE family. GatB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0064.
KOiK02434.
OMAiRNPRAIN.
OrthoDBiEOG6RJV5B.

Family and domain databases

HAMAPiMF_00121. GatB.
InterProiIPR004413. Apn/Gln-ADT_bsu.
IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
[Graphical view]
PANTHERiPTHR11659. PTHR11659. 1 hit.
PfamiPF02934. GatB_N. 1 hit.
PF02637. GatB_Yqey. 1 hit.
[Graphical view]
SMARTiSM00845. GatB_Yqey. 1 hit.
[Graphical view]
SUPFAMiSSF89095. SSF89095. 1 hit.
TIGRFAMsiTIGR00133. gatB. 1 hit.
PROSITEiPS01234. GATB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8ZLK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFETVIGLE VHVELNTNSK IFSPTSAHFG NDQNANTNVI DWSFPGVLPV
60 70 80 90 100
LNKGVVDAGI KAALALNMDI HKKMHFDRKN YFYPDNPKAY QISQFDEPIG
110 120 130 140 150
YNGWIEVELE DGTTKKIGIE RAHLEEDAGK NTHGTDGYSY VDLNRQGVPL
160 170 180 190 200
IEIVSEADMR SPEEAYAYLT ALKEVIQYAG ISDVKMEEGS MRVDANISLR
210 220 230 240 250
PYGQEKFGTK TELKNLNSFS NVRKGLEYEV QRQAEILRSG GQIRQETRRY
260 270 280 290 300
DEANKATILM RVKEGAADYR YFPEPDLPLF EISDEWIEEM RTELPEFPKE
310 320 330 340 350
RRARYVSDLG LSDYDASQLT ANKVTSNFFE KAVALGGDAK QVSNWLQGEV
360 370 380 390 400
AQFLNAEGKT LEQIELTPEN LVEMITIIED GTISSKIAKK VFVHLAKNGG
410 420 430 440 450
GAREYVEKAG MVQISDPAIL IPIIHQVFAD NEAAVADFKS GKRNADKAFT
460 470 480
GFLMRATKGQ ANPQVALKLL AQELAKLKEN
Length:480
Mass (Da):53,716
Last modified:March 3, 2009 - v1
Checksum:iC21C477E1BD7FDBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA. Translation: CAR68258.1.
RefSeqiYP_002510451.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR68258; CAR68258; SPN23F04090.
GeneIDi7329251.
KEGGisne:SPN23F_04090.
PATRICi19672080. VBIStrPne132160_0443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM211187 Genomic DNA. Translation: CAR68258.1 .
RefSeqi YP_002510451.1. NC_011900.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_04090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR68258 ; CAR68258 ; SPN23F04090 .
GeneIDi 7329251.
KEGGi sne:SPN23F_04090.
PATRICi 19672080. VBIStrPne132160_0443.

Phylogenomic databases

eggNOGi COG0064.
KOi K02434.
OMAi RNPRAIN.
OrthoDBi EOG6RJV5B.

Enzyme and pathway databases

BioCyci SPNE561276:GJFJ-403-MONOMER.

Family and domain databases

HAMAPi MF_00121. GatB.
InterProi IPR004413. Apn/Gln-ADT_bsu.
IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
IPR018027. Asn/Gln_amidotransferase.
IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
[Graphical view ]
PANTHERi PTHR11659. PTHR11659. 1 hit.
Pfami PF02934. GatB_N. 1 hit.
PF02637. GatB_Yqey. 1 hit.
[Graphical view ]
SMARTi SM00845. GatB_Yqey. 1 hit.
[Graphical view ]
SUPFAMi SSF89095. SSF89095. 1 hit.
TIGRFAMsi TIGR00133. gatB. 1 hit.
PROSITEi PS01234. GATB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiGATB_STRPJ
AccessioniPrimary (citable) accession number: B8ZLK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3