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B8ZLK0

- GATB_STRPJ

UniProt

B8ZLK0 - GATB_STRPJ

Protein

Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B

Gene

gatB

Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation
    ATP + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE561276:GJFJ-403-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BUniRule annotation (EC:6.3.5.-UniRule annotation)
    Short name:
    Asp/Glu-ADT subunit BUniRule annotation
    Gene namesi
    Name:gatBUniRule annotation
    Ordered Locus Names:SPN23F04090
    OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
    Taxonomic identifieri561276 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002600: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit BPRO_1000122537Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi561276.SPN23F_04090.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GatB/GatE family. GatB subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0064.
    KOiK02434.
    OMAiRNPRAIN.
    OrthoDBiEOG6RJV5B.

    Family and domain databases

    HAMAPiMF_00121. GatB.
    InterProiIPR004413. Apn/Gln-ADT_bsu.
    IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
    IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
    IPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
    [Graphical view]
    PANTHERiPTHR11659. PTHR11659. 1 hit.
    PfamiPF02934. GatB_N. 1 hit.
    PF02637. GatB_Yqey. 1 hit.
    [Graphical view]
    SMARTiSM00845. GatB_Yqey. 1 hit.
    [Graphical view]
    SUPFAMiSSF89095. SSF89095. 1 hit.
    TIGRFAMsiTIGR00133. gatB. 1 hit.
    PROSITEiPS01234. GATB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8ZLK0-1 [UniParc]FASTAAdd to Basket

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    MNFETVIGLE VHVELNTNSK IFSPTSAHFG NDQNANTNVI DWSFPGVLPV    50
    LNKGVVDAGI KAALALNMDI HKKMHFDRKN YFYPDNPKAY QISQFDEPIG 100
    YNGWIEVELE DGTTKKIGIE RAHLEEDAGK NTHGTDGYSY VDLNRQGVPL 150
    IEIVSEADMR SPEEAYAYLT ALKEVIQYAG ISDVKMEEGS MRVDANISLR 200
    PYGQEKFGTK TELKNLNSFS NVRKGLEYEV QRQAEILRSG GQIRQETRRY 250
    DEANKATILM RVKEGAADYR YFPEPDLPLF EISDEWIEEM RTELPEFPKE 300
    RRARYVSDLG LSDYDASQLT ANKVTSNFFE KAVALGGDAK QVSNWLQGEV 350
    AQFLNAEGKT LEQIELTPEN LVEMITIIED GTISSKIAKK VFVHLAKNGG 400
    GAREYVEKAG MVQISDPAIL IPIIHQVFAD NEAAVADFKS GKRNADKAFT 450
    GFLMRATKGQ ANPQVALKLL AQELAKLKEN 480
    Length:480
    Mass (Da):53,716
    Last modified:March 3, 2009 - v1
    Checksum:iC21C477E1BD7FDBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211187 Genomic DNA. Translation: CAR68258.1.
    RefSeqiYP_002510451.1. NC_011900.1.

    Genome annotation databases

    EnsemblBacteriaiCAR68258; CAR68258; SPN23F04090.
    GeneIDi7329251.
    KEGGisne:SPN23F_04090.
    PATRICi19672080. VBIStrPne132160_0443.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM211187 Genomic DNA. Translation: CAR68258.1 .
    RefSeqi YP_002510451.1. NC_011900.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561276.SPN23F_04090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR68258 ; CAR68258 ; SPN23F04090 .
    GeneIDi 7329251.
    KEGGi sne:SPN23F_04090.
    PATRICi 19672080. VBIStrPne132160_0443.

    Phylogenomic databases

    eggNOGi COG0064.
    KOi K02434.
    OMAi RNPRAIN.
    OrthoDBi EOG6RJV5B.

    Enzyme and pathway databases

    BioCyci SPNE561276:GJFJ-403-MONOMER.

    Family and domain databases

    HAMAPi MF_00121. GatB.
    InterProi IPR004413. Apn/Gln-ADT_bsu.
    IPR017959. Asn/Gln-tRNA_amidoTrfase_suB/E.
    IPR006075. Asn/Gln-tRNA_Trfase_suB/E_cat.
    IPR018027. Asn/Gln_amidotransferase.
    IPR003789. Asn/Gln_tRNA_amidoTrfrase-rel.
    IPR017958. Gln-tRNA_amidoTrfase_suB_CS.
    [Graphical view ]
    PANTHERi PTHR11659. PTHR11659. 1 hit.
    Pfami PF02934. GatB_N. 1 hit.
    PF02637. GatB_Yqey. 1 hit.
    [Graphical view ]
    SMARTi SM00845. GatB_Yqey. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89095. SSF89095. 1 hit.
    TIGRFAMsi TIGR00133. gatB. 1 hit.
    PROSITEi PS01234. GATB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
      Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
      J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700669 / Spain 23F-1.

    Entry informationi

    Entry nameiGATB_STRPJ
    AccessioniPrimary (citable) accession number: B8ZLK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3