B8ZKM6 (AROD_STRPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SPN23F13430

Organism

Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) [Complete proteome] [HAMAP]

Taxonomic identifier

561276 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000124788
Sites
	Active site	118	1	Proton acceptor By similarity
	Active site	143	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8ZKM6 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: BBC4CCFF2D5052C7	FASTA	225	25,725
	10 20 30 40 50 60 MKLIVSVMPR SLEEAQALSA TRYLDADIIE WRADYLPKEA ILQVAPAIFE KFAGRELVFT 70 80 90 100 110 120 LRTRSEGGEI DLSPEEYIHL IKEVAQFYQP DYIDFEYYSY KDVFEEMLDF PNLVLSYHNF 130 140 150 160 170 180 QETPENMMEI LSELTILNPK LVKVAVMAHT EQDVLDLMNY TRGFKTLNPE QEYVTISMGK 190 200 210 220 VGKVSRITAD VTGSSWSFAS LDEVSAPGQI SLASMKKIRE ILDEA

References

[1]

"Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81." Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J. J. Bacteriol. 191:1480-1489(2009) [PubMed: 19114491] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700669 / Spain 23F-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM211187 Genomic DNA. Translation: CAR69143.1.
RefSeq	YP_002511272.1. NC_011900.1.
3D structure databases
ProteinModelPortal	B8ZKM6.
ModBase	Search...
Protein-protein interaction databases
STRING	B8ZKM6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000071265; EBSTRP00000066446; EBSTRG00000071166.
GeneID	7328661.
GenomeReviews	Gene locus SPN23F13430 in contig FM211187_GR.
PATRIC	19674040. VBIStrPne132160_1422.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027890.
HOGENOM	HBG732926.
OMA	VARRTVI.
ProtClustDB	PRK02412.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STRPJ

Accession

Primary (citable) accession number: B8ZKM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program