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B8ZJN3

- PUR9_STRPJ

UniProt

B8ZJN3 - PUR9_STRPJ

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, SPN23F00670
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-68-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:SPN23F00670
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122974Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561276.SPN23F_00670.

Structurei

3D structure databases

ProteinModelPortaliB8ZJN3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZJN3-1 [UniParc]FASTAAdd to Basket

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MTKRVLISVS DKAGIVEFAQ ELKKLGWEII STGGTKVALD NAGVDTIAID    50
DVTGFPEMMD GRVKTLHPNI HGGLLARRDL DSHLEAAKDN KIELIDLVVV 100
NLYPFKETIL KPDVTYADAV ENIDIGGPSM LRSAAKNHAS VTVVVDPADY 150
AVVLDELAAN GETSYETRQR LAAKVFRHTA AYDALIAEYF TAQVGESKPE 200
KLTLTYDLKQ PMRYGENPQQ DADFYQKALP TDYSIASAKQ LNGKELSFNN 250
IRDADAAIRI IRDFKDSPTV VALKHMNPCG IGQADDIETA WDYAYESDPV 300
SIFGGIVVLN REVDAATAEK MHGVFLEIII APSYTDEALA ILINKKKNLR 350
ILALPFNAQE ASEVEAEYTG VVGGLLVQNQ DVVKESPADW QVVTKRQPTE 400
TEATALEFAW KAIKYVKSNG IIVTNDHMTL GVGPGQTNRV ASVRLAIDQA 450
KDRLNGAVLA SDAFFPFADN VEEIAKAGIK AIIQPGGSVR DQEFIEAADK 500
YGLTMVFTGV RHFRH 515
Length:515
Mass (Da):56,353
Last modified:March 3, 2009 - v1
Checksum:i7A77317E750C83E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR67927.1.
RefSeqiYP_002510151.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR67927; CAR67927; SPN23F00670.
GeneIDi7329427.
KEGGisne:SPN23F_00670.
PATRICi19671333. VBIStrPne132160_0069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR67927.1 .
RefSeqi YP_002510151.1. NC_011900.1.

3D structure databases

ProteinModelPortali B8ZJN3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_00670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR67927 ; CAR67927 ; SPN23F00670 .
GeneIDi 7329427.
KEGGi sne:SPN23F_00670.
PATRICi 19671333. VBIStrPne132160_0069.

Phylogenomic databases

eggNOGi COG0138.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SPNE561276:GJFJ-68-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiPUR9_STRPJ
AccessioniPrimary (citable) accession number: B8ZJN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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