SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B8ZJN0

- PUR5_STRPJ

UniProt

B8ZJN0 - PUR5_STRPJ

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SPN23F00640
Organism
Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE561276:GJFJ-65-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SPN23F00640
OrganismiStreptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
Taxonomic identifieri561276 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002600: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000148300Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561276.SPN23F_00640.

Structurei

3D structure databases

ProteinModelPortaliB8ZJN0.
SMRiB8ZJN0. Positions 15-333.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
KOiK01933.
OMAiPDMYGAD.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B8ZJN0-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKNAYAQS GVDVEAGYEV VERIKKHVAR TERAGVMGAL GGFGGMFDLS    50
KTGVKEPVLI SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE 100
PLYFLDYVAT GKNEPAKLEQ VVAGVAEGCV QAGAALIGGE TAEMPGMYGE 150
DDYDLAGFAV GVAEKSQIID GSKVVEGDVL LGLASSGIHS NGYSLVRRVF 200
ADYTGEEVLP ELEGKKLKEV LLEPTRIYVK AVLPLIKEEL VNGIAHITGG 250
GFIENVPRMF ADDLAAEIDE SKVPVLPIFK ALEKYGQIKH EEMFEIFNMG 300
VGLMLAVSPE NVERVKELLD EAVYEIGRIV KKENESVIIK 340
Length:340
Mass (Da):36,502
Last modified:March 3, 2009 - v1
Checksum:iE346F704D72AF9FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR67924.1.
RefSeqiYP_002510148.1. NC_011900.1.

Genome annotation databases

EnsemblBacteriaiCAR67924; CAR67924; SPN23F00640.
GeneIDi7327421.
KEGGisne:SPN23F_00640.
PATRICi19671327. VBIStrPne132160_0066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM211187 Genomic DNA. Translation: CAR67924.1 .
RefSeqi YP_002510148.1. NC_011900.1.

3D structure databases

ProteinModelPortali B8ZJN0.
SMRi B8ZJN0. Positions 15-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561276.SPN23F_00640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR67924 ; CAR67924 ; SPN23F00640 .
GeneIDi 7327421.
KEGGi sne:SPN23F_00640.
PATRICi 19671327. VBIStrPne132160_0066.

Phylogenomic databases

eggNOGi COG0150.
KOi K01933.
OMAi PDMYGAD.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SPNE561276:GJFJ-65-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81."
    Croucher N.J., Walker D., Romero P., Lennard N., Paterson G.K., Bason N.C., Mitchell A.M., Quail M.A., Andrew P.W., Parkhill J., Bentley S.D., Mitchell T.J.
    J. Bacteriol. 191:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700669 / Spain 23F-1.

Entry informationi

Entry nameiPUR5_STRPJ
AccessioniPrimary (citable) accession number: B8ZJN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi