ID   B8Y441_CRIGR            Unreviewed;       417 AA.
AC   B8Y441;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=Neu3 {ECO:0000313|EMBL:ACL52161.1,
GN   ECO:0000313|RefSeq:NP_001231029.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:ACL52161.1};
RN   [1] {ECO:0000313|EMBL:ACL52161.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang M.;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|RefSeq:NP_001231029.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-
CC         (2->8)- glycosidic linkages of terminal sialic acid residues in
CC         oligosaccharides, glycoproteins, glycolipids, colominic acid and
CC         synthetic substrates.; EC=3.2.1.18;
CC         Evidence={ECO:0000256|ARBA:ARBA00000427};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; FJ476074; ACL52161.1; -; mRNA.
DR   RefSeq; NP_001231029.1; NM_001244100.1.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   GeneID; 100689090; -.
DR   KEGG; cge:100689090; -.
DR   CTD; 10825; -.
DR   OrthoDB; 5482010at2759; -.
DR   Proteomes; UP001108280; Chromosome 3.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF23; SIALIDASE-3; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   2: Evidence at transcript level;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          48..376
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   417 AA;  46806 MW;  529F1AF98DAB4A3F CRC64;
     MEEVSACSLN STLFQQEHQK GTTYRIPALL YIPPSHTFLA FAEKRSSSKD VDALHLVLRR
     GVMKGHSVEW GPLQPLMEAT LPGHRTMNPC PVWEQSTSRV LLFFICVPDR VTEHWQIRSG
     KNAARLCFLC SQDAGCSWGE VKDLTEEVIG SELKHWATFA VGPGHGIRLQ SGRLIIPTYA
     YYFSCRFLCF PCSVKPHSLM IYSDDLGVTW HHGKLIGPQV TGECQVAEVT GTSGNLVLYC
     NARTPNRFRA ESFSTDYGDC FQKPTLNTQL CEPRYGCQGS IVSFQPLKMP FSQDPIGKAA
     PTTQKSPLLD SFLEREEGVG RPSGTWLLYS HPTSKKRRIN LGIYYNRNPL EVTCWSRPWI
     LHCGPCGYSD LAVVEEQGLF ACLFECGQEH ECEQIAFRLF SVQEVLSCED CTGPSRD
//