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Protein

Potassium channel toxin BuTXK-beta

Gene
N/A
Organism
Buthus occitanus israelis (Common yellow scorpion)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Blocks voltage-gated potassium channels.By similarity

GO - Biological processi

  1. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin BuTXK-beta
Short name:
BuTXKbeta
Alternative name(s):
Potassium channel toxin Tx690
OrganismiButhus occitanus israelis (Common yellow scorpion)
Taxonomic identifieri539894 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Propeptidei20 – 278By similarityPRO_0000394024
Chaini28 – 9164Potassium channel toxin BuTXK-betaPRO_0000394025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 78By similarity
Disulfide bondi64 ↔ 83By similarity
Disulfide bondi68 ↔ 85By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8XH40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNLVVLLL LGMVALSSCG LREKHFQKLV KYAVPESTLR TILQTAVHKL
60 70 80 90
GKTQFGCPAY QGYCDDHCQD IKKEEGFCHG MKCKCGIPMG F
Length:91
Mass (Da):10,192
Last modified:March 3, 2009 - v1
Checksum:i75EC9BDEFA436D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ360829 mRNA. Translation: ACJ23149.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ360829 mRNA. Translation: ACJ23149.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Buthus occitanus israelis scorpion toxin."
    Zilberberg N., Kozminsky-Atias A.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKBX1_BUTOS
AccessioniPrimary (citable) accession number: B8XH40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 3, 2009
Last modified: January 7, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.