B8XH40 (KBX1_BUTOS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel toxin BuTXK-beta Short name=BuTXKbeta Alternative name(s): Potassium channel toxin Tx690
Organism	Buthus occitanus israelis (Common yellow scorpion)
Taxonomic identifier	539894 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus › Buthus occitanus

Protein attributes

Sequence length	91 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Blocks voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Propeptide	20 – 27	8	By similarity		PRO_0000394024
	Chain	28 – 91	64	Potassium channel toxin BuTXK-beta		PRO_0000394025
Amino acid modifications
	Disulfide bond	57 ↔ 78		By similarity
	Disulfide bond	64 ↔ 83		By similarity
	Disulfide bond	68 ↔ 85		By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8XH40 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 75EC9BDEFA436D95	FASTA	91	10,192
	10 20 30 40 50 60 MQRNLVVLLL LGMVALSSCG LREKHFQKLV KYAVPESTLR TILQTAVHKL GKTQFGCPAY 70 80 90 QGYCDDHCQD IKKEEGFCHG MKCKCGIPMG F

References

[1]	"Buthus occitanus israelis scorpion toxin." Zilberberg N., Kozminsky-Atias A. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	FJ360829 mRNA. Translation: ACJ23149.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003614. Scorpion_toxin-like. [Graphical view]
SMART	SM00505. Knot1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KBX1_BUTOS

Accession

Primary (citable) accession number: B8XH40

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 18, 2010
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program