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B8XH40 (KBX1_BUTOS) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin BuTXK-beta

Short name=BuTXKbeta
Alternative name(s):
Potassium channel toxin Tx690
OrganismButhus occitanus israelis (Common yellow scorpion)
Taxonomic identifier539894 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Blocks voltage-gated potassium channels By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Propeptide20 – 278 By similarity
PRO_0000394024
Chain28 – 9164Potassium channel toxin BuTXK-beta
PRO_0000394025

Amino acid modifications

Disulfide bond57 ↔ 78 By similarity
Disulfide bond64 ↔ 83 By similarity
Disulfide bond68 ↔ 85 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8XH40 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 75EC9BDEFA436D95

FASTA9110,192
        10         20         30         40         50         60 
MQRNLVVLLL LGMVALSSCG LREKHFQKLV KYAVPESTLR TILQTAVHKL GKTQFGCPAY 

        70         80         90 
QGYCDDHCQD IKKEEGFCHG MKCKCGIPMG F 

« Hide

References

[1]"Buthus occitanus israelis scorpion toxin."
Zilberberg N., Kozminsky-Atias A.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ360829 mRNA. Translation: ACJ23149.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR003614. Scorpion_toxin-like.
[Graphical view]
SMARTSM00505. Knot1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKBX1_BUTOS
AccessionPrimary (citable) accession number: B8XH40
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 3, 2009
Last modified: October 16, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries