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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Trichophyton equinum (Horse ringworm fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Active sitei520PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERitriru-q5j6j0. Carboxypeptidase_S10.
MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
Synonyms:CarbY
OrganismiTrichophyton equinum (Horse ringworm fungus)
Taxonomic identifieri63418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaeTrichophyton

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040748218 – 124By similarityAdd BLAST107
ChainiPRO_0000407483125 – 543Carboxypeptidase Y homolog AAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi179 ↔ 419By similarity
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi313 ↔ 327By similarity
Disulfide bondi337 ↔ 360By similarity
Disulfide bondi344 ↔ 353By similarity
Disulfide bondi382 ↔ 389By similarity
Glycosylationi509N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8XGR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLTTGLLA TAALAAAQEQ QVLQAEDGMG QAPQRGSSIF DETLQKFQSS
60 70 80 90 100
LEDGISHFWS EMKTNFKDYL PLISLPKKHT RRPDSEWDHV VRGADIESVW
110 120 130 140 150
VQGADGEKRR EIDGKLHNYD LRVKAVDPSK LGVDAGVKQY SGYLDDNDAD
160 170 180 190 200
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PATIDKNLKV
210 220 230 240 250
VSNPYSWNSN ASVIFLDQPV NVGFSYSGSS VSDTVAAGKD VYALLTLFFK
260 270 280 290 300
QFPEYATQDF HISGESYAGH YIPVFAAEIL SHKNTNINLK SALIGNGLTD
310 320 330 340 350
PLTQYPQYRP MACGEGGYPA VLDQGTCRSM DNSLERCLSL IETCYSSESA
360 370 380 390 400
WVCVPAAMYC NSAILAPYQQ TGMNPYDVRN KCEDMASLCY PQLNVITEWL
410 420 430 440 450
NQKSVMQALG VEVESYESCN SGINRDFLFH GDWMKPYHRL VPSVLEKIPV
460 470 480 490 500
LIYAGDADFI CNWLGNQAWT DALEWPGHKK FAEAKLEDLK IVDNKNKGKK
510 520 530 540
IGQVKSSGNF TFMRIFGAGH MVPLNQPEAS LEFLNRWLRG EWH
Length:543
Mass (Da):60,711
Last modified:March 3, 2009 - v1
Checksum:iD7948DAE58A54235
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ348246 Genomic DNA. Translation: ACL37336.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ348246 Genomic DNA. Translation: ACL37336.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERitriru-q5j6j0. Carboxypeptidase_S10.
MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_TRIEQ
AccessioniPrimary (citable) accession number: B8XGR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: March 16, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.