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B8XGR4

- CBPYA_TRIEQ

UniProt

B8XGR4 - CBPYA_TRIEQ

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Protein

Carboxypeptidase Y homolog A

Gene
CPYA, CarbY
Organism
Trichophyton equinum (Horse ringworm fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661 By similarity
Active sitei458 – 4581 By similarity
Active sitei520 – 5201 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
Synonyms:CarbY
OrganismiTrichophyton equinum (Horse ringworm fungus)
Taxonomic identifieri63418 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesArthrodermataceaemitosporic ArthrodermataceaeTrichophyton

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 124107 By similarityPRO_0000407482Add
BLAST
Chaini125 – 543419Carboxypeptidase Y homolog APRO_0000407483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 419 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi313 ↔ 327 By similarity
Disulfide bondi337 ↔ 360 By similarity
Disulfide bondi344 ↔ 353 By similarity
Disulfide bondi382 ↔ 389 By similarity
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8XGR4-1 [UniParc]FASTAAdd to Basket

« Hide

MKFLTTGLLA TAALAAAQEQ QVLQAEDGMG QAPQRGSSIF DETLQKFQSS    50
LEDGISHFWS EMKTNFKDYL PLISLPKKHT RRPDSEWDHV VRGADIESVW 100
VQGADGEKRR EIDGKLHNYD LRVKAVDPSK LGVDAGVKQY SGYLDDNDAD 150
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PATIDKNLKV 200
VSNPYSWNSN ASVIFLDQPV NVGFSYSGSS VSDTVAAGKD VYALLTLFFK 250
QFPEYATQDF HISGESYAGH YIPVFAAEIL SHKNTNINLK SALIGNGLTD 300
PLTQYPQYRP MACGEGGYPA VLDQGTCRSM DNSLERCLSL IETCYSSESA 350
WVCVPAAMYC NSAILAPYQQ TGMNPYDVRN KCEDMASLCY PQLNVITEWL 400
NQKSVMQALG VEVESYESCN SGINRDFLFH GDWMKPYHRL VPSVLEKIPV 450
LIYAGDADFI CNWLGNQAWT DALEWPGHKK FAEAKLEDLK IVDNKNKGKK 500
IGQVKSSGNF TFMRIFGAGH MVPLNQPEAS LEFLNRWLRG EWH 543
Length:543
Mass (Da):60,711
Last modified:March 3, 2009 - v1
Checksum:iD7948DAE58A54235
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ348246 Genomic DNA. Translation: ACL37336.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ348246 Genomic DNA. Translation: ACL37336.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparing putative pathogenicity factors between Trichophyton tonsurans and Trichophyton equinum."
    Preuett B.L., Abdel-Rahman S.M.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCBPYA_TRIEQ
AccessioniPrimary (citable) accession number: B8XGR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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