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B8XA41

- SBS_SOLHA

UniProt

B8XA41 - SBS_SOLHA

Protein

Santalene and bergamotene synthase, chloroplastic

Gene

SBS

Organism
Solanum habrochaites (Wild tomato) (Lycopersicon hirsutum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    (2Z,6Z)-farnesyl diphosphate cyclizing enzyme. Produces (+)-alpha-santalene, (+)-endo-beta-bergamotene, (-)-endo-alpha-bergamotene, and at lower amounts, (-)exo-alpha-bergamotene and (+)-epi-beta-santalene. Not able to use geranyl diphosphate, E,E-farnesyl diphosphate or E,E,E-geranylgeranyl diphosphate as substrates, but able to use Neryl diphosphate to make the monoterpene terpineol.1 Publication

    Catalytic activityi

    (2Z,6Z)-farnesyl diphosphate = (+)-alpha-santalene.1 Publication
    (2Z,6Z)-farnesyl diphosphate = (+)-endo-beta-bergamotene.1 Publication
    (2Z,6Z)-farnesyl diphosphate = (-)-endo-alpha-bergamotene.1 Publication

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi530 – 5301Magnesium or manganese 1By similarity
    Metal bindingi530 – 5301Magnesium or manganese 2By similarity
    Metal bindingi534 – 5341Magnesium or manganese 1By similarity
    Metal bindingi534 – 5341Magnesium or manganese 2By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. terpene synthase activity Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-14819.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Santalene and bergamotene synthase, chloroplastic
    Alternative name(s):
    (+)-alpha-santalene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) (EC:4.2.3.50)
    (+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) (EC:4.2.3.53)
    (-)-endo-alpha-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) (EC:4.2.3.54)
    Gene namesi
    Name:SBS
    OrganismiSolanum habrochaites (Wild tomato) (Lycopersicon hirsutum)
    Taxonomic identifieri62890 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

    Subcellular locationi

    Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636ChloroplastSequence AnalysisAdd
    BLAST
    Chaini37 – 777741Santalene and bergamotene synthase, chloroplasticPRO_0000405118Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB8XA41.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi530 – 5345DDXXD motif

    Domaini

    The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.By similarity

    Sequence similaritiesi

    Belongs to the terpene synthase family. Tpse subfamily.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    1.50.10.20. 1 hit.
    1.50.30.10. 1 hit.
    InterProiIPR001906. Terpene_synth_N.
    IPR005630. Terpene_synthase_metal-bd.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF01397. Terpene_synth. 1 hit.
    PF03936. Terpene_synth_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 3 hits.
    SSF48576. SSF48576. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8XA41-1 [UniParc]FASTAAdd to Basket

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    MIVGYRSTII TLSHPKLGNG KTISSNAIFQ RSCRVRCSHS TPSSMNGFED    50
    ARDRIRESFG KVELSPSSYD TAWVAMVPSK HSLNEPCFPQ CLDWIIENQR 100
    EDGSWGLNPS HPLLLKDSLS STLACLLALT KWRVGDEQIK RGLGFIETQS 150
    WAIDNKDQIS PLGFEIIFPS MIKSAEKLNL NLAINKRDST IKRALQNEFT 200
    RNIEYMSEGV GELCDWKEII KLHQRQNGSL FDSPATTAAA LIYHQHDKKC 250
    YEYLNSILQQ HKNWVPTMYP TKIHSLLCLV DTLQNLGVHR HFKSEIKKAL 300
    DEIYRLWQQK NEQIFSNVTH CAMAFRLLRM SYYDVSSDEL AEFVDEEHFF 350
    AISGKYTSHV EILELHKASQ LAIDHEKDDI LDKINNWTRT FMEQKLLNNG 400
    FIDRMSKKEV ELALRKFYTI SDLAENRRCI KSYEENNFKI LKAAYRSPNI 450
    YNKDLFIFSI RNFELCQAQH QEELQQFKRW FEDYRLDQLG IAERYIHDTY 500
    LCAVIVVPEP ELSDARLLYA KYVLLLTIVD DQFDSFASTD ECLNIIELVE 550
    RWDDYASVGY KSEKVKVFFS TLYKSIEELV TIAEIKQGRS VKNHLLNLWL 600
    ELVKLMLMER VEWFSGKTIP SIEEYLYVTS ITFGARLIPL TTQYFLGIKI 650
    SEDILESDEI YGLCNCTGRV LRILNDLQDS KKEQKEDSVT IVTLLMKSMS 700
    EEEAIMKIKE ILEMNRRELL KMVLVQKKGS QLPQICKDIF WRTSNWADFI 750
    YLQTDGYRIA EEMKNHIDEV FYKPLNH 777
    Length:777
    Mass (Da):90,626
    Last modified:March 3, 2009 - v1
    Checksum:iAE19AD4DA742979D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ194970 mRNA. Translation: ACJ38409.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ194970 mRNA. Translation: ACJ38409.1 .

    3D structure databases

    ProteinModelPortali B8XA41.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-14819.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    1.50.10.20. 1 hit.
    1.50.30.10. 1 hit.
    InterProi IPR001906. Terpene_synth_N.
    IPR005630. Terpene_synthase_metal-bd.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF01397. Terpene_synth. 1 hit.
    PF03936. Terpene_synth_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 3 hits.
    SSF48576. SSF48576. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites."
      Sallaud C., Rontein D., Onillon S., Jabes F., Duffe P., Giacalone C., Thoraval S., Escoffier C., Herbette G., Leonhardt N., Causse M., Tissier A.
      Plant Cell 21:301-317(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, FUNCTION.
      Tissue: Trichome gland.

    Entry informationi

    Entry nameiSBS_SOLHA
    AccessioniPrimary (citable) accession number: B8XA41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 8, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3