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Protein

Beta-lactamase

Gene

penB1

Organism
Burkholderia cenocepacia
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi3.5.2.6. 8982.

Protein family/group databases

MEROPSiS11.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:penB1Imported
OrganismiBurkholderia cenocepaciaImported
Taxonomic identifieri95486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1641339.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500287815528 – 312Beta-lactamaseSequence analysisAdd BLAST285

Structurei

3D structure databases

ProteinModelPortaliB8R6A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.

Sequencei

Sequence statusi: Complete.

B8R6A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYSSKRRTL LLAAATAPLV LTATACASRQ AAAPDPATAA AAAAADAMAP
60 70 80 90 100
AAAAATLADL ERDAGGRLGV CAIDTASGRV IEHRAGERFP FCSTFKAMLS
110 120 130 140 150
AAVLAQSVER PGLLQQRVKY TKADLVNYSP VSEKHVGAGM TVAALCEATI
160 170 180 190 200
QYSDNSAANL LMKLIGGPSA VTAYARSIGD DAFRLDRWET ELNTALPGDP
210 220 230 240 250
RDTTTPAAMA ASIRVLTLGD ALPAAQRAQL VAWLRGNKVG DKRIRAGVPA
260 270 280 290 300
GWTVGDKTGT GDYGTTNDAG VIWPTSRAPI VLAVYYTQTR ADARAKDDVI
310
ASVARIVAQT FG
Length:312
Mass (Da):32,377
Last modified:March 3, 2009 - v1
Checksum:i33B9E4023E08CF87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU872211 Genomic DNA. Translation: ACJ63454.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB8R6A5_9BURK
AccessioniPrimary (citable) accession number: B8R6A5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 5, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)