B8R5H1 (B8R5H1_LOTGI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Malate dehydrogenase RuleBase RU003405 EC=1.1.1.37 RuleBase RU003405
Organism	Lottia gigantea (Owl limpet) EMBL ACJ64675.1
Taxonomic identifier	225164 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Mollusca › Gastropoda › Patellogastropoda › Lottioidea › Lottiidae › Lottia

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU003405
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003405
Ligand	NAD RuleBase RU003405
Molecular function	Oxidoreductase RuleBase RU000421 EMBL ACJ64675.1
Gene Ontology (GO)
Biological process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8R5H1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: CCDF5C2F98181833	FASTA	332	36,033
	10 20 30 40 50 60 MSEPVKVLVT GAAGQIAYSL LYSIAKGDVF GDKQPISLVL LDIEPMMAVL DGVVMELQDC 70 80 90 100 110 120 ALPLLADVIP TADEAAAFKD IDVALLVGAQ PRRQGMERKD LLKANVKIFK SQGAALDAHA 130 140 150 160 170 180 KKTVKVVVVG NPANTNALVI SKFAPSIPKE NFSCLTRLDQ NRAQAQVASK LGISNENVQR 190 200 210 220 230 240 TIIWGNHSST QFPDLAHAVV HVNGKLMPAQ EAIKDDNWVK NDFIKTVQTR GGAVIQARKL 250 260 270 280 290 300 SSAMSAAKAI CDHVRDWWFG TGERWVSMGI ISKGDYGIQQ GLMYSFPVQI GTDKVVQVVP 310 320 330 GLTISDFARE KMDATQAELV EERDCAFLFL EA

References

[1]

"Temperature adaptation of cytosolic malate dehydrogenases of limpets (genus Lottia): differences in stability and function due to minor changes in sequence correlate with biogeographic and vertical distributions." Dong Y., Somero G.N. J. Exp. Biol. 212:169-177(2009) [PubMed: 19112135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU863455 mRNA. Translation: ACJ64675.1.
3D structure databases
ProteinModelPortal	B8R5H1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
OMA	NFSAMTR.
Family and domain databases
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR011274. Malate_DH_NAD-dep_euk. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23382. MDH_SF1. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01759. MalateDH-SF1. 1 hit. TIGR01758. MDH_euk_cyt. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8R5H1_LOTGI

Accession

Primary (citable) accession number: B8R5H1

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)