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B8QGZ3 (BGALA_PENEN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase A

EC=3.2.1.23
Alternative name(s):
Lactase A
Gene names
Name:lacA
OrganismPenicillium expansum (Blue mold rot fungus)
Taxonomic identifier27334 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

Protein attributes

Sequence length1011 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 1011993Probable beta-galactosidase A
PRO_0000395222

Sites

Active site2001Proton donor Potential
Active site2991Nucleophile Potential
Binding site961Substrate By similarity
Binding site1401Substrate By similarity
Binding site1411Substrate; via amide nitrogen By similarity
Binding site1421Substrate By similarity
Binding site1991Substrate By similarity
Binding site2611Substrate By similarity
Binding site3651Substrate By similarity

Amino acid modifications

Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation4031N-linked (GlcNAc...) Potential
Glycosylation6251N-linked (GlcNAc...) Potential
Glycosylation7631N-linked (GlcNAc...) Potential
Glycosylation7801N-linked (GlcNAc...) Potential
Glycosylation9171N-linked (GlcNAc...) Potential
Disulfide bond205 ↔ 206 By similarity
Disulfide bond267 ↔ 316 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8QGZ3 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 9362248E6B7B2552

FASTA1,011110,414
        10         20         30         40         50         60 
MKLLSSLALA ALAAQVSGAA ISHKLDGFTL REHADASKRE LLQKYVTWDK HSIFINGERL 

        70         80         90        100        110        120 
MMFSGEVHPY RLPVASLYID VFEKIKALGF NCVSFYVDWA LLEGKPGHYT AEGIFDLQPF 

       130        140        150        160        170        180 
FDAAKEAGIY LLARPGPYIN AEVSGGGFPG WLQRVNGTLR TSIGDYLKST DNYASHIAKT 

       190        200        210        220        230        240 
IAKAQITNGG PIILYQPENE YSGACCGYED FPDGSYMQYI EDHARDAGIV VPFISNDAYA 

       250        260        270        280        290        300 
GGHNAPGTGK GAVDIYGHDG YPLGFDCANP SVWPDGNLPT NYHTLHEEQS PTTPFSVVEF 

       310        320        330        340        350        360 
QGGAFDPWGG VGFAKCAHLL NHEFERVFYK NDFSFGVTFF NLYMIFGGTN WGNLGHPGGY 

       370        380        390        400        410        420 
TSYDYGSAIS ESRNVTREKY SELKLLGNFA KVSPGYVVAN PGNLTTSKYT KTADLTVTPL 

       430        440        450        460        470        480 
LGESSSAGSF FVIRHSNYNS QASVKYQLTL PTSAGELTIP QLGGELTLSG RDSKIHVTDY 

       490        500        510        520        530        540 
DVAGSNILYS TAEVFTWKKF DNGKVLILYG GPGEHHEFAV TGASASSVIE GSSSGITSKK 

       550        560        570        580        590        600 
IGDALVVAWD VSSKRRIIKI GDLKVFLLDR NSAYNYWVPH LPTKGKAPGY VSKKAIDSSI 

       610        620        630        640        650        660 
IVKAGYLVRS AFLSGKDLHI QADFNATTPI EIIGAPSSAK NLVINGKKTK TNVDDNGIWS 

       670        680        690        700        710        720 
ASVSYSTPEI HLPSLKDLKW QSIDTLPEVK NSYDDSAWTS ADQPHTLNTA HELQTPTTLF 

       730        740        750        760        770        780 
SSDYGYHTGT LLYRGHFVAN GKESIFFIQT QGGSAYGHSV WVNETYVGSW EGSGSNDNYN 

       790        800        810        820        830        840 
ATYTLPSLAT GKKYAITVVI DNMGLDVNWV IGQEGMKNPR GIIRYNLAGH DASAISWKLT 

       850        860        870        880        890        900 
GNLGGEDYRD TVRGPLNEGG LYAERQGFHQ PKPSTKNWDS SSPFTGLTKP GIRFYSASFD 

       910        920        930        940        950        960 
LDLPSGYDIP LYFNFGNSTA PPDAYRVQLF VNGYQYGKYV NNVGPQTSFP VPEGILNYHG 

       970        980        990       1000       1010 
TNWIALSLWA QQESGAKLNS FELINTTPVL TSLDKVKSVD QPKYKSRKGA Y 

« Hide

References

[1]"Purification and molecular cloning of beta-galactosidase from Penicillium expansum F3."
Li Y.M., Xiao M.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: F3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU543998 mRNA. Translation: ACD75821.1.
EU543999 Genomic DNA. Translation: ACD75822.1.

3D structure databases

ProteinModelPortalB8QGZ3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGALA_PENEN
AccessionPrimary (citable) accession number: B8QGZ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries