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B8QGZ3

- BGALA_PENEN

UniProt

B8QGZ3 - BGALA_PENEN

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Protein
Probable beta-galactosidase A
Gene
lacA
Organism
Penicillium expansum (Blue mold rot fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961Substrate By similarity
Binding sitei140 – 1401Substrate By similarity
Binding sitei141 – 1411Substrate; via amide nitrogen By similarity
Binding sitei142 – 1421Substrate By similarity
Binding sitei199 – 1991Substrate By similarity
Active sitei200 – 2001Proton donor Reviewed prediction
Binding sitei261 – 2611Substrate By similarity
Active sitei299 – 2991Nucleophile Reviewed prediction
Binding sitei365 – 3651Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase A (EC:3.2.1.23)
Alternative name(s):
Lactase A
Gene namesi
Name:lacA
OrganismiPenicillium expansum (Blue mold rot fungus)
Taxonomic identifieri27334 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 1011993Probable beta-galactosidase A
PRO_0000395222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi205 ↔ 206 By similarity
Disulfide bondi267 ↔ 316 By similarity
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi403 – 4031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi625 – 6251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi763 – 7631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi780 – 7801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi917 – 9171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8QGZ3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8QGZ3-1 [UniParc]FASTAAdd to Basket

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MKLLSSLALA ALAAQVSGAA ISHKLDGFTL REHADASKRE LLQKYVTWDK     50
HSIFINGERL MMFSGEVHPY RLPVASLYID VFEKIKALGF NCVSFYVDWA 100
LLEGKPGHYT AEGIFDLQPF FDAAKEAGIY LLARPGPYIN AEVSGGGFPG 150
WLQRVNGTLR TSIGDYLKST DNYASHIAKT IAKAQITNGG PIILYQPENE 200
YSGACCGYED FPDGSYMQYI EDHARDAGIV VPFISNDAYA GGHNAPGTGK 250
GAVDIYGHDG YPLGFDCANP SVWPDGNLPT NYHTLHEEQS PTTPFSVVEF 300
QGGAFDPWGG VGFAKCAHLL NHEFERVFYK NDFSFGVTFF NLYMIFGGTN 350
WGNLGHPGGY TSYDYGSAIS ESRNVTREKY SELKLLGNFA KVSPGYVVAN 400
PGNLTTSKYT KTADLTVTPL LGESSSAGSF FVIRHSNYNS QASVKYQLTL 450
PTSAGELTIP QLGGELTLSG RDSKIHVTDY DVAGSNILYS TAEVFTWKKF 500
DNGKVLILYG GPGEHHEFAV TGASASSVIE GSSSGITSKK IGDALVVAWD 550
VSSKRRIIKI GDLKVFLLDR NSAYNYWVPH LPTKGKAPGY VSKKAIDSSI 600
IVKAGYLVRS AFLSGKDLHI QADFNATTPI EIIGAPSSAK NLVINGKKTK 650
TNVDDNGIWS ASVSYSTPEI HLPSLKDLKW QSIDTLPEVK NSYDDSAWTS 700
ADQPHTLNTA HELQTPTTLF SSDYGYHTGT LLYRGHFVAN GKESIFFIQT 750
QGGSAYGHSV WVNETYVGSW EGSGSNDNYN ATYTLPSLAT GKKYAITVVI 800
DNMGLDVNWV IGQEGMKNPR GIIRYNLAGH DASAISWKLT GNLGGEDYRD 850
TVRGPLNEGG LYAERQGFHQ PKPSTKNWDS SSPFTGLTKP GIRFYSASFD 900
LDLPSGYDIP LYFNFGNSTA PPDAYRVQLF VNGYQYGKYV NNVGPQTSFP 950
VPEGILNYHG TNWIALSLWA QQESGAKLNS FELINTTPVL TSLDKVKSVD 1000
QPKYKSRKGA Y 1011
Length:1,011
Mass (Da):110,414
Last modified:March 3, 2009 - v1
Checksum:i9362248E6B7B2552
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU543998 mRNA. Translation: ACD75821.1.
EU543999 Genomic DNA. Translation: ACD75822.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU543998 mRNA. Translation: ACD75821.1 .
EU543999 Genomic DNA. Translation: ACD75822.1 .

3D structure databases

ProteinModelPortali B8QGZ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and molecular cloning of beta-galactosidase from Penicillium expansum F3."
    Li Y.M., Xiao M.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: F3.

Entry informationi

Entry nameiBGALA_PENEN
AccessioniPrimary (citable) accession number: B8QGZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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