Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B8QGZ3

- BGALA_PENEN

UniProt

B8QGZ3 - BGALA_PENEN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable beta-galactosidase A

Gene

lacA

Organism
Penicillium expansum (Blue mold rot fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961SubstrateBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Binding sitei141 – 1411Substrate; via amide nitrogenBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Binding sitei199 – 1991SubstrateBy similarity
Active sitei200 – 2001Proton donorSequence Analysis
Binding sitei261 – 2611SubstrateBy similarity
Active sitei299 – 2991NucleophileSequence Analysis
Binding sitei365 – 3651SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase A (EC:3.2.1.23)
Alternative name(s):
Lactase A
Gene namesi
Name:lacA
OrganismiPenicillium expansum (Blue mold rot fungus)
Taxonomic identifieri27334 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicillium

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 1011993Probable beta-galactosidase APRO_0000395222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi205 ↔ 206By similarity
Disulfide bondi267 ↔ 316By similarity
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi763 – 7631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi780 – 7801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi917 – 9171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8QGZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8QGZ3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLSSLALA ALAAQVSGAA ISHKLDGFTL REHADASKRE LLQKYVTWDK
60 70 80 90 100
HSIFINGERL MMFSGEVHPY RLPVASLYID VFEKIKALGF NCVSFYVDWA
110 120 130 140 150
LLEGKPGHYT AEGIFDLQPF FDAAKEAGIY LLARPGPYIN AEVSGGGFPG
160 170 180 190 200
WLQRVNGTLR TSIGDYLKST DNYASHIAKT IAKAQITNGG PIILYQPENE
210 220 230 240 250
YSGACCGYED FPDGSYMQYI EDHARDAGIV VPFISNDAYA GGHNAPGTGK
260 270 280 290 300
GAVDIYGHDG YPLGFDCANP SVWPDGNLPT NYHTLHEEQS PTTPFSVVEF
310 320 330 340 350
QGGAFDPWGG VGFAKCAHLL NHEFERVFYK NDFSFGVTFF NLYMIFGGTN
360 370 380 390 400
WGNLGHPGGY TSYDYGSAIS ESRNVTREKY SELKLLGNFA KVSPGYVVAN
410 420 430 440 450
PGNLTTSKYT KTADLTVTPL LGESSSAGSF FVIRHSNYNS QASVKYQLTL
460 470 480 490 500
PTSAGELTIP QLGGELTLSG RDSKIHVTDY DVAGSNILYS TAEVFTWKKF
510 520 530 540 550
DNGKVLILYG GPGEHHEFAV TGASASSVIE GSSSGITSKK IGDALVVAWD
560 570 580 590 600
VSSKRRIIKI GDLKVFLLDR NSAYNYWVPH LPTKGKAPGY VSKKAIDSSI
610 620 630 640 650
IVKAGYLVRS AFLSGKDLHI QADFNATTPI EIIGAPSSAK NLVINGKKTK
660 670 680 690 700
TNVDDNGIWS ASVSYSTPEI HLPSLKDLKW QSIDTLPEVK NSYDDSAWTS
710 720 730 740 750
ADQPHTLNTA HELQTPTTLF SSDYGYHTGT LLYRGHFVAN GKESIFFIQT
760 770 780 790 800
QGGSAYGHSV WVNETYVGSW EGSGSNDNYN ATYTLPSLAT GKKYAITVVI
810 820 830 840 850
DNMGLDVNWV IGQEGMKNPR GIIRYNLAGH DASAISWKLT GNLGGEDYRD
860 870 880 890 900
TVRGPLNEGG LYAERQGFHQ PKPSTKNWDS SSPFTGLTKP GIRFYSASFD
910 920 930 940 950
LDLPSGYDIP LYFNFGNSTA PPDAYRVQLF VNGYQYGKYV NNVGPQTSFP
960 970 980 990 1000
VPEGILNYHG TNWIALSLWA QQESGAKLNS FELINTTPVL TSLDKVKSVD
1010
QPKYKSRKGA Y
Length:1,011
Mass (Da):110,414
Last modified:March 3, 2009 - v1
Checksum:i9362248E6B7B2552
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU543998 mRNA. Translation: ACD75821.1.
EU543999 Genomic DNA. Translation: ACD75822.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU543998 mRNA. Translation: ACD75821.1 .
EU543999 Genomic DNA. Translation: ACD75822.1 .

3D structure databases

ProteinModelPortali B8QGZ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Purification and molecular cloning of beta-galactosidase from Penicillium expansum F3."
    Li Y.M., Xiao M.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: F3.

Entry informationi

Entry nameiBGALA_PENEN
AccessioniPrimary (citable) accession number: B8QGZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3