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B8NXS9

- CBPYA_ASPFN

UniProt

B8NXS9 - CBPYA_ASPFN

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei265 – 2651PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation
    Active sitei519 – 5191PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:AFLA_008990
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 123106By similarityPRO_0000407432Add
    BLAST
    Chaini124 – 542419Carboxypeptidase Y homolog APRO_0000407433Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi178 ↔ 418By similarity
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi312 ↔ 326By similarity
    Disulfide bondi336 ↔ 359By similarity
    Disulfide bondi343 ↔ 352By similarity
    Disulfide bondi381 ↔ 388By similarity
    Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00013009.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    KOiK13289.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8NXS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVLPATLLV GAASAAVPPL QQVLGRPEEG MSFSKPLHAF QEQLKTLSED    50
    ARKLWDEVAN YFPDSMDHSP IFSLPKKHTR RPDSHWDHIV RGSDVQKIWV 100
    NNADGEKERE IDGKLEAYDL RVKKADPSAL GIDPNVKQYT GYLDDNGNDK 150
    HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFMELGP SSIDENIKPV 200
    YNDFSWNSNA SVIFLDQPVN VGYSYSGSAV SDTVAAGKDV YALLSLFFKQ 250
    FPEYAEQDFH IAGESYAGHY IPVFASEILA HKNRNINLKS VLIGNGLTDG 300
    LTQYGYYRPM GCGEGGYKAV LDEATCESMD NALPRCRSMI ESCYNSESAW 350
    VCVPASIYCN NALIGPYQRT GQNVYDVRSK CEDESNLCYK GMGYVSEYLN 400
    KAEVREAVGA EVGGYDSCNF DINRNFLFHG DWMKPYHRLV PGLLEQIPVL 450
    IYAGDADYIC NWLGNKAWTE ALEWPGQKEY ASAELEDLKI EQNEHTGKKI 500
    GQVKSHGNFT FMRLYGGGHM VPMDQPEASL EFFNRWLGGE WF 542
    Length:542
    Mass (Da):60,878
    Last modified:March 3, 2009 - v1
    Checksum:iC9A6E7A124D3DA17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963486 Genomic DNA. Translation: EED45015.1.
    RefSeqiXP_002385144.1. XM_002385103.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00013009; CADAFLAP00013009; CADAFLAG00013009.
    GeneIDi7918529.
    KEGGiafv:AFLA_008990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963486 Genomic DNA. Translation: EED45015.1 .
    RefSeqi XP_002385144.1. XM_002385103.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00013009.

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00013009 ; CADAFLAP00013009 ; CADAFLAG00013009 .
    GeneIDi 7918529.
    KEGGi afv:AFLA_008990.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    KOi K13289.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiCBPYA_ASPFN
    AccessioniPrimary (citable) accession number: B8NXS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3