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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651PROSITE-ProRule annotation
Active sitei457 – 4571PROSITE-ProRule annotation
Active sitei519 – 5191PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:AFLA_008990
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_008990.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 123106By similarityPRO_0000407432Add
BLAST
Chaini124 – 542419Carboxypeptidase Y homolog APRO_0000407433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 418By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 326By similarity
Disulfide bondi336 ↔ 359By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi381 ↔ 388By similarity
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00013009.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiGQKEYAS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8NXS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLPATLLV GAASAAVPPL QQVLGRPEEG MSFSKPLHAF QEQLKTLSED
60 70 80 90 100
ARKLWDEVAN YFPDSMDHSP IFSLPKKHTR RPDSHWDHIV RGSDVQKIWV
110 120 130 140 150
NNADGEKERE IDGKLEAYDL RVKKADPSAL GIDPNVKQYT GYLDDNGNDK
160 170 180 190 200
HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFMELGP SSIDENIKPV
210 220 230 240 250
YNDFSWNSNA SVIFLDQPVN VGYSYSGSAV SDTVAAGKDV YALLSLFFKQ
260 270 280 290 300
FPEYAEQDFH IAGESYAGHY IPVFASEILA HKNRNINLKS VLIGNGLTDG
310 320 330 340 350
LTQYGYYRPM GCGEGGYKAV LDEATCESMD NALPRCRSMI ESCYNSESAW
360 370 380 390 400
VCVPASIYCN NALIGPYQRT GQNVYDVRSK CEDESNLCYK GMGYVSEYLN
410 420 430 440 450
KAEVREAVGA EVGGYDSCNF DINRNFLFHG DWMKPYHRLV PGLLEQIPVL
460 470 480 490 500
IYAGDADYIC NWLGNKAWTE ALEWPGQKEY ASAELEDLKI EQNEHTGKKI
510 520 530 540
GQVKSHGNFT FMRLYGGGHM VPMDQPEASL EFFNRWLGGE WF
Length:542
Mass (Da):60,878
Last modified:March 3, 2009 - v1
Checksum:iC9A6E7A124D3DA17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963486 Genomic DNA. Translation: EED45015.1.
RefSeqiXP_002385144.1. XM_002385103.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00013009; CADAFLAP00013009; CADAFLAG00013009.
GeneIDi7918529.
KEGGiafv:AFLA_008990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963486 Genomic DNA. Translation: EED45015.1.
RefSeqiXP_002385144.1. XM_002385103.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5059.CADAFLAP00013009.

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFLAT00013009; CADAFLAP00013009; CADAFLAG00013009.
GeneIDi7918529.
KEGGiafv:AFLA_008990.

Organism-specific databases

EuPathDBiFungiDB:AFLA_008990.

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiGQKEYAS.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiCBPYA_ASPFN
AccessioniPrimary (citable) accession number: B8NXS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: April 29, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.