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B8NXS9 (CBPYA_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carboxypeptidase Y homolog A

EC=3.4.16.5
Gene names
Name:cpyA
ORF Names:AFLA_008990
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activity

Release of a C-terminal amino acid with broad specificity.

Subcellular location

Vacuole By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Cellular componentVacuole
   DomainSignal
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentvacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Propeptide18 – 123106 By similarity
PRO_0000407432
Chain124 – 542419Carboxypeptidase Y homolog A
PRO_0000407433

Sites

Active site2651 By similarity
Active site4571 By similarity
Active site5191 By similarity

Amino acid modifications

Glycosylation2091N-linked (GlcNAc...) Potential
Glycosylation5081N-linked (GlcNAc...) Potential
Disulfide bond178 ↔ 418 By similarity
Disulfide bond312 ↔ 326 By similarity
Disulfide bond336 ↔ 359 By similarity
Disulfide bond343 ↔ 352 By similarity
Disulfide bond381 ↔ 388 By similarity

Sequences

Sequence LengthMass (Da)Tools
B8NXS9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C9A6E7A124D3DA17

FASTA54260,878
        10         20         30         40         50         60 
MRVLPATLLV GAASAAVPPL QQVLGRPEEG MSFSKPLHAF QEQLKTLSED ARKLWDEVAN 

        70         80         90        100        110        120 
YFPDSMDHSP IFSLPKKHTR RPDSHWDHIV RGSDVQKIWV NNADGEKERE IDGKLEAYDL 

       130        140        150        160        170        180 
RVKKADPSAL GIDPNVKQYT GYLDDNGNDK HLFYWFFESR NDPKNDPVVL WLNGGPGCSS 

       190        200        210        220        230        240 
LTGLFMELGP SSIDENIKPV YNDFSWNSNA SVIFLDQPVN VGYSYSGSAV SDTVAAGKDV 

       250        260        270        280        290        300 
YALLSLFFKQ FPEYAEQDFH IAGESYAGHY IPVFASEILA HKNRNINLKS VLIGNGLTDG 

       310        320        330        340        350        360 
LTQYGYYRPM GCGEGGYKAV LDEATCESMD NALPRCRSMI ESCYNSESAW VCVPASIYCN 

       370        380        390        400        410        420 
NALIGPYQRT GQNVYDVRSK CEDESNLCYK GMGYVSEYLN KAEVREAVGA EVGGYDSCNF 

       430        440        450        460        470        480 
DINRNFLFHG DWMKPYHRLV PGLLEQIPVL IYAGDADYIC NWLGNKAWTE ALEWPGQKEY 

       490        500        510        520        530        540 
ASAELEDLKI EQNEHTGKKI GQVKSHGNFT FMRLYGGGHM VPMDQPEASL EFFNRWLGGE 


WF 

« Hide

References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ963486 Genomic DNA. Translation: EED45015.1.
RefSeqXP_002385144.1. XM_002385103.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5059.CADAFLAP00013009.

Protein family/group databases

MEROPSS10.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00013009; CADAFLAP00013009; CADAFLAG00013009.
GeneID7918529.
KEGGafv:AFLA_008990.

Phylogenomic databases

eggNOGCOG2939.
HOGENOMHOG000198296.
KOK13289.
OMAWPGQKEY.
OrthoDBEOG7XDBR1.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBPYA_ASPFN
AccessionPrimary (citable) accession number: B8NXS9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries