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B8NXS9

- CBPYA_ASPFN

UniProt

B8NXS9 - CBPYA_ASPFN

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Protein

Carboxypeptidase Y homolog A

Gene
cpyA, AFLA_008990
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651 By similarity
Active sitei457 – 4571 By similarity
Active sitei519 – 5191 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:AFLA_008990
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Propeptidei18 – 123106 By similarityPRO_0000407432Add
BLAST
Chaini124 – 542419Carboxypeptidase Y homolog APRO_0000407433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 418 By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi312 ↔ 326 By similarity
Disulfide bondi336 ↔ 359 By similarity
Disulfide bondi343 ↔ 352 By similarity
Disulfide bondi381 ↔ 388 By similarity
Glycosylationi508 – 5081N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00013009.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiWPGQKEY.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8NXS9-1 [UniParc]FASTAAdd to Basket

« Hide

MRVLPATLLV GAASAAVPPL QQVLGRPEEG MSFSKPLHAF QEQLKTLSED    50
ARKLWDEVAN YFPDSMDHSP IFSLPKKHTR RPDSHWDHIV RGSDVQKIWV 100
NNADGEKERE IDGKLEAYDL RVKKADPSAL GIDPNVKQYT GYLDDNGNDK 150
HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFMELGP SSIDENIKPV 200
YNDFSWNSNA SVIFLDQPVN VGYSYSGSAV SDTVAAGKDV YALLSLFFKQ 250
FPEYAEQDFH IAGESYAGHY IPVFASEILA HKNRNINLKS VLIGNGLTDG 300
LTQYGYYRPM GCGEGGYKAV LDEATCESMD NALPRCRSMI ESCYNSESAW 350
VCVPASIYCN NALIGPYQRT GQNVYDVRSK CEDESNLCYK GMGYVSEYLN 400
KAEVREAVGA EVGGYDSCNF DINRNFLFHG DWMKPYHRLV PGLLEQIPVL 450
IYAGDADYIC NWLGNKAWTE ALEWPGQKEY ASAELEDLKI EQNEHTGKKI 500
GQVKSHGNFT FMRLYGGGHM VPMDQPEASL EFFNRWLGGE WF 542
Length:542
Mass (Da):60,878
Last modified:March 3, 2009 - v1
Checksum:iC9A6E7A124D3DA17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963486 Genomic DNA. Translation: EED45015.1.
RefSeqiXP_002385144.1. XM_002385103.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00013009; CADAFLAP00013009; CADAFLAG00013009.
GeneIDi7918529.
KEGGiafv:AFLA_008990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963486 Genomic DNA. Translation: EED45015.1 .
RefSeqi XP_002385144.1. XM_002385103.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00013009.

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00013009 ; CADAFLAP00013009 ; CADAFLAG00013009 .
GeneIDi 7918529.
KEGGi afv:AFLA_008990.

Phylogenomic databases

eggNOGi COG2939.
HOGENOMi HOG000198296.
KOi K13289.
OMAi WPGQKEY.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiCBPYA_ASPFN
AccessioniPrimary (citable) accession number: B8NXS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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