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Protein

Glutamate decarboxylase

Gene

AFLA_008890

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
ORF Names:AFLA_008890Imported
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)Imported
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00012999.

Structurei

3D structure databases

ProteinModelPortaliB8NXR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

B8NXR9-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVHLAQVHRN ADLDSTIKRV DSIQLENTDE DGFYSSVYGT RFATEQLPQT
60 70 80 90 100
EMPEREMPRE VAYRMIKDEL SLDGNPMLNL ASFVTTYMED EAEKLMTESF
110 120 130 140 150
SKNFIDYEEY PQSAEIQNRC VNMIARLFNA PVHSEDEHPM GTSTIGSSEA
160 170 180 190 200
IMLGTLAMKR RWQNKRKAEG KDYSRPNIVM NSAVQVCWEK AARYFDVEER
210 220 230 240 250
YVYCTEDRYV IDPQQAVDLV DENTIGICAI LGTTYTGEYE DVKAINDLLI
260 270 280 290 300
ERNIDVPIHV DAASGGFVAP FINPKLEWDF RLPKVVSINV SGHKYGLVYP
310 320 330 340 350
GVGWVVWRSP EYLPKDLIFN INYLGAEQAS FTLNFSKGAS QVIGQYYQMI
360 370 380 390 400
RLGKRGYRSI MTNITVTADF LAQELEKMGF IIMSQRRGHG LPLVAFRLPA
410 420 430 440 450
EREGQFDEFA LAHQLRERGW IVPAYTMAPN SNNLKLMRVV VREDFTKSRC
460 470 480 490 500
DALLSDIKLG LKTLGDMDKA MLDKYTQHVR THATHSHKSK HNHPHYKGET
510
HSLQGKHGKT HGVC
Length:514
Mass (Da):58,660
Last modified:March 3, 2009 - v1
Checksum:i1B10E19A93F28AA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963486 Genomic DNA. Translation: EED45005.1.
RefSeqiXP_002385134.1. XM_002385093.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00012999; CADAFLAP00012999; CADAFLAG00012999.
GeneIDi7918519.
KEGGiafv:AFLA_008890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963486 Genomic DNA. Translation: EED45005.1.
RefSeqiXP_002385134.1. XM_002385093.1.

3D structure databases

ProteinModelPortaliB8NXR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5059.CADAFLAP00012999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFLAT00012999; CADAFLAP00012999; CADAFLAG00012999.
GeneIDi7918519.
KEGGiafv:AFLA_008890.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG7P2Z22.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167Imported.

Entry informationi

Entry nameiB8NXR9_ASPFN
AccessioniPrimary (citable) accession number: B8NXR9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: February 4, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.