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B8NTI4

- XKS1_ASPFN

UniProt

B8NTI4 - XKS1_ASPFN

Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.By similarity

    Catalytic activityi

    ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei95 – 951SubstrateBy similarity
    Binding sitei166 – 1661SubstrateBy similarity
    Binding sitei282 – 2821SubstrateBy similarity
    Binding sitei283 – 2831SubstrateBy similarity
    Binding sitei365 – 3651ATPBy similarity
    Binding sitei474 – 4741ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi470 – 4712ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. xylulokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Xylose metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable D-xylulose kinase A (EC:2.7.1.17)
    Short name:
    Xylulokinase A
    Gene namesi
    Name:xkiA
    ORF Names:AFLA_098240
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Probable D-xylulose kinase APRO_0000393518Add
    BLAST

    Expressioni

    Inductioni

    By D-xylose, L-arabinose or L-arabitol.

    Interactioni

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00011562.

    Structurei

    3D structure databases

    ProteinModelPortaliB8NTI4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG1070.
    HOGENOMiHOG000174850.
    KOiK00854.
    OMAiMARAHVE.
    OrthoDBiEOG7CRTZN.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8NTI4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQGPLYIGFD LSTQQLKALV VNSDLKVVYV SKFDFDADSR GFPIKKGVIT    50
    NEAEHEVYAP VALWLQALDG VLEGLKKQGL DFARVKGISG AGQQHGSVYW 100
    GQDAERLLKE LDSGKSLEDQ LSGAFSHPYS PNWQDSSTQK ECDEFDAFLG 150
    GADKLANATG SKAHHRFTGP QILRFQRKYP EVYKKTSRIS LVSSFLASLF 200
    LGHIAPLDIS DACGMNLWNI KQGAYDEKLL QLCAGPSGVE DLKRKLGAVP 250
    EDGGINLGQI DRYYIERYGF SSDCTIIPAT GDNPATILAL PLRPSDAMVS 300
    LGTSTTFLMS TPNYMPDPAT HFFNHPTTAG LYMFMLCYKN GGLAREHIRD 350
    AINDKLGMAG DKDPWANFDK ITLETAPMGQ KKDSDPMKMG LFFPRPEIVP 400
    NLRAGQWRFD YNPADGSLHE TNGGWNKPAD EARAIVESQF LSLRLRSRGL 450
    TASPGQGMPA QPRRVYLVGG GSKNKAIAKV AGEILGGSDG VYKLEIGDNA 500
    CALGAAYKAV WALERKDGQT FEDLIGQRWR EEDFIEKIAD GYQKGVFEKY 550
    GAALEGFEKM ELQVLKQEGE TR 572
    Length:572
    Mass (Da):62,910
    Last modified:March 3, 2009 - v1
    Checksum:iE8A5D99221835427
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963484 Genomic DNA. Translation: EED46161.1.
    RefSeqiXP_002383697.1. XM_002383656.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00011562; CADAFLAP00011562; CADAFLAG00011562.
    GeneIDi7910699.
    KEGGiafv:AFLA_098240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963484 Genomic DNA. Translation: EED46161.1 .
    RefSeqi XP_002383697.1. XM_002383656.1.

    3D structure databases

    ProteinModelPortali B8NTI4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00011562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00011562 ; CADAFLAP00011562 ; CADAFLAG00011562 .
    GeneIDi 7910699.
    KEGGi afv:AFLA_098240.

    Phylogenomic databases

    eggNOGi COG1070.
    HOGENOMi HOG000174850.
    KOi K00854.
    OMAi MARAHVE.
    OrthoDBi EOG7CRTZN.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018484. Carb_kinase_FGGY_N.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiXKS1_ASPFN
    AccessioniPrimary (citable) accession number: B8NTI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3