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B8NTI4

- XKS1_ASPFN

UniProt

B8NTI4 - XKS1_ASPFN

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Protein

Probable D-xylulose kinase A

Gene
xkiA, AFLA_098240
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei282 – 2821Substrate By similarity
Binding sitei283 – 2831Substrate By similarity
Binding sitei365 – 3651ATP By similarity
Binding sitei474 – 4741ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi470 – 4712ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:AFLA_098240
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Probable D-xylulose kinase APRO_0000393518Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00011562.

Structurei

3D structure databases

ProteinModelPortaliB8NTI4.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
KOiK00854.
OMAiMARAHVE.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8NTI4-1 [UniParc]FASTAAdd to Basket

« Hide

MQGPLYIGFD LSTQQLKALV VNSDLKVVYV SKFDFDADSR GFPIKKGVIT    50
NEAEHEVYAP VALWLQALDG VLEGLKKQGL DFARVKGISG AGQQHGSVYW 100
GQDAERLLKE LDSGKSLEDQ LSGAFSHPYS PNWQDSSTQK ECDEFDAFLG 150
GADKLANATG SKAHHRFTGP QILRFQRKYP EVYKKTSRIS LVSSFLASLF 200
LGHIAPLDIS DACGMNLWNI KQGAYDEKLL QLCAGPSGVE DLKRKLGAVP 250
EDGGINLGQI DRYYIERYGF SSDCTIIPAT GDNPATILAL PLRPSDAMVS 300
LGTSTTFLMS TPNYMPDPAT HFFNHPTTAG LYMFMLCYKN GGLAREHIRD 350
AINDKLGMAG DKDPWANFDK ITLETAPMGQ KKDSDPMKMG LFFPRPEIVP 400
NLRAGQWRFD YNPADGSLHE TNGGWNKPAD EARAIVESQF LSLRLRSRGL 450
TASPGQGMPA QPRRVYLVGG GSKNKAIAKV AGEILGGSDG VYKLEIGDNA 500
CALGAAYKAV WALERKDGQT FEDLIGQRWR EEDFIEKIAD GYQKGVFEKY 550
GAALEGFEKM ELQVLKQEGE TR 572
Length:572
Mass (Da):62,910
Last modified:March 3, 2009 - v1
Checksum:iE8A5D99221835427
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963484 Genomic DNA. Translation: EED46161.1.
RefSeqiXP_002383697.1. XM_002383656.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00011562; CADAFLAP00011562; CADAFLAG00011562.
GeneIDi7910699.
KEGGiafv:AFLA_098240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963484 Genomic DNA. Translation: EED46161.1 .
RefSeqi XP_002383697.1. XM_002383656.1.

3D structure databases

ProteinModelPortali B8NTI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00011562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00011562 ; CADAFLAP00011562 ; CADAFLAG00011562 .
GeneIDi 7910699.
KEGGi afv:AFLA_098240.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
KOi K00854.
OMAi MARAHVE.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiXKS1_ASPFN
AccessioniPrimary (citable) accession number: B8NTI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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