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B8NTI4

- XKS1_ASPFN

UniProt

B8NTI4 - XKS1_ASPFN

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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951SubstrateBy similarity
Binding sitei166 – 1661SubstrateBy similarity
Binding sitei282 – 2821SubstrateBy similarity
Binding sitei283 – 2831SubstrateBy similarity
Binding sitei365 – 3651ATPBy similarity
Binding sitei474 – 4741ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi470 – 4712ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. xylulokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Xylose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:AFLA_098240
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 572572Probable D-xylulose kinase APRO_0000393518Add
BLAST

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00011562.

Structurei

3D structure databases

ProteinModelPortaliB8NTI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiCOG1070.
HOGENOMiHOG000174850.
KOiK00854.
OMAiMARAHVE.
OrthoDBiEOG7CRTZN.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8NTI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQGPLYIGFD LSTQQLKALV VNSDLKVVYV SKFDFDADSR GFPIKKGVIT
60 70 80 90 100
NEAEHEVYAP VALWLQALDG VLEGLKKQGL DFARVKGISG AGQQHGSVYW
110 120 130 140 150
GQDAERLLKE LDSGKSLEDQ LSGAFSHPYS PNWQDSSTQK ECDEFDAFLG
160 170 180 190 200
GADKLANATG SKAHHRFTGP QILRFQRKYP EVYKKTSRIS LVSSFLASLF
210 220 230 240 250
LGHIAPLDIS DACGMNLWNI KQGAYDEKLL QLCAGPSGVE DLKRKLGAVP
260 270 280 290 300
EDGGINLGQI DRYYIERYGF SSDCTIIPAT GDNPATILAL PLRPSDAMVS
310 320 330 340 350
LGTSTTFLMS TPNYMPDPAT HFFNHPTTAG LYMFMLCYKN GGLAREHIRD
360 370 380 390 400
AINDKLGMAG DKDPWANFDK ITLETAPMGQ KKDSDPMKMG LFFPRPEIVP
410 420 430 440 450
NLRAGQWRFD YNPADGSLHE TNGGWNKPAD EARAIVESQF LSLRLRSRGL
460 470 480 490 500
TASPGQGMPA QPRRVYLVGG GSKNKAIAKV AGEILGGSDG VYKLEIGDNA
510 520 530 540 550
CALGAAYKAV WALERKDGQT FEDLIGQRWR EEDFIEKIAD GYQKGVFEKY
560 570
GAALEGFEKM ELQVLKQEGE TR
Length:572
Mass (Da):62,910
Last modified:March 3, 2009 - v1
Checksum:iE8A5D99221835427
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963484 Genomic DNA. Translation: EED46161.1.
RefSeqiXP_002383697.1. XM_002383656.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00011562; CADAFLAP00011562; CADAFLAG00011562.
GeneIDi7910699.
KEGGiafv:AFLA_098240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963484 Genomic DNA. Translation: EED46161.1 .
RefSeqi XP_002383697.1. XM_002383656.1.

3D structure databases

ProteinModelPortali B8NTI4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00011562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00011562 ; CADAFLAP00011562 ; CADAFLAG00011562 .
GeneIDi 7910699.
KEGGi afv:AFLA_098240.

Phylogenomic databases

eggNOGi COG1070.
HOGENOMi HOG000174850.
KOi K00854.
OMAi MARAHVE.
OrthoDBi EOG7CRTZN.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiXKS1_ASPFN
AccessioniPrimary (citable) accession number: B8NTI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3