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B8NTI4 (XKS1_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable D-xylulose kinase A

Short name=Xylulokinase A
EC=2.7.1.17
Gene names
Name:xkiA
ORF Names:AFLA_098240
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Subcellular location

Cytoplasm By similarity.

Induction

By D-xylose, L-arabinose or L-arabitol.

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Xylose metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylulokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Probable D-xylulose kinase A
PRO_0000393518

Regions

Nucleotide binding470 – 4712ATP By similarity

Sites

Binding site951Substrate By similarity
Binding site1661Substrate By similarity
Binding site2821Substrate By similarity
Binding site2831Substrate By similarity
Binding site3651ATP By similarity
Binding site4741ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8NTI4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: E8A5D99221835427

FASTA57262,910
        10         20         30         40         50         60 
MQGPLYIGFD LSTQQLKALV VNSDLKVVYV SKFDFDADSR GFPIKKGVIT NEAEHEVYAP 

        70         80         90        100        110        120 
VALWLQALDG VLEGLKKQGL DFARVKGISG AGQQHGSVYW GQDAERLLKE LDSGKSLEDQ 

       130        140        150        160        170        180 
LSGAFSHPYS PNWQDSSTQK ECDEFDAFLG GADKLANATG SKAHHRFTGP QILRFQRKYP 

       190        200        210        220        230        240 
EVYKKTSRIS LVSSFLASLF LGHIAPLDIS DACGMNLWNI KQGAYDEKLL QLCAGPSGVE 

       250        260        270        280        290        300 
DLKRKLGAVP EDGGINLGQI DRYYIERYGF SSDCTIIPAT GDNPATILAL PLRPSDAMVS 

       310        320        330        340        350        360 
LGTSTTFLMS TPNYMPDPAT HFFNHPTTAG LYMFMLCYKN GGLAREHIRD AINDKLGMAG 

       370        380        390        400        410        420 
DKDPWANFDK ITLETAPMGQ KKDSDPMKMG LFFPRPEIVP NLRAGQWRFD YNPADGSLHE 

       430        440        450        460        470        480 
TNGGWNKPAD EARAIVESQF LSLRLRSRGL TASPGQGMPA QPRRVYLVGG GSKNKAIAKV 

       490        500        510        520        530        540 
AGEILGGSDG VYKLEIGDNA CALGAAYKAV WALERKDGQT FEDLIGQRWR EEDFIEKIAD 

       550        560        570 
GYQKGVFEKY GAALEGFEKM ELQVLKQEGE TR 

« Hide

References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ963484 Genomic DNA. Translation: EED46161.1.
RefSeqXP_002383697.1. XM_002383656.1.

3D structure databases

ProteinModelPortalB8NTI4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5059.CADAFLAP00011562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00011562; CADAFLAP00011562; CADAFLAG00011562.
GeneID7910699.
KEGGafv:AFLA_098240.

Phylogenomic databases

eggNOGCOG1070.
HOGENOMHOG000174850.
KOK00854.
OMAAACGLNR.
OrthoDBEOG7CRTZN.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXKS1_ASPFN
AccessionPrimary (citable) accession number: B8NTI4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families