B8NTI4 (XKS1_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable D-xylulose kinase A
Short name=Xylulokinase A
EC=2.7.1.17

Gene names

Name:	xkiA
ORF Names:	AFLA_098240

Organism

Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]

Taxonomic identifier

332952 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus flavus

Protein attributes

Sequence length	572 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.
Catalytic activity	ATP + D-xylulose = ADP + D-xylulose 5-phosphate.
Subcellular location	Cytoplasm By similarity.
Induction	By D-xylose, L-arabinose or L-arabitol.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Xylose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW xylulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 572	572	Probable D-xylulose kinase A		PRO_0000393518

Sequences

	Sequence		Length	Mass (Da)
	B8NTI4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: E8A5D99221835427	FASTA	572	62,910
	10 20 30 40 50 60 MQGPLYIGFD LSTQQLKALV VNSDLKVVYV SKFDFDADSR GFPIKKGVIT NEAEHEVYAP 70 80 90 100 110 120 VALWLQALDG VLEGLKKQGL DFARVKGISG AGQQHGSVYW GQDAERLLKE LDSGKSLEDQ 130 140 150 160 170 180 LSGAFSHPYS PNWQDSSTQK ECDEFDAFLG GADKLANATG SKAHHRFTGP QILRFQRKYP 190 200 210 220 230 240 EVYKKTSRIS LVSSFLASLF LGHIAPLDIS DACGMNLWNI KQGAYDEKLL QLCAGPSGVE 250 260 270 280 290 300 DLKRKLGAVP EDGGINLGQI DRYYIERYGF SSDCTIIPAT GDNPATILAL PLRPSDAMVS 310 320 330 340 350 360 LGTSTTFLMS TPNYMPDPAT HFFNHPTTAG LYMFMLCYKN GGLAREHIRD AINDKLGMAG 370 380 390 400 410 420 DKDPWANFDK ITLETAPMGQ KKDSDPMKMG LFFPRPEIVP NLRAGQWRFD YNPADGSLHE 430 440 450 460 470 480 TNGGWNKPAD EARAIVESQF LSLRLRSRGL TASPGQGMPA QPRRVYLVGG GSKNKAIAKV 490 500 510 520 530 540 AGEILGGSDG VYKLEIGDNA CALGAAYKAV WALERKDGQT FEDLIGQRWR EEDFIEKIAD 550 560 570 GYQKGVFEKY GAALEGFEKM ELQVLKQEGE TR

References

[1]

"Genome sequence of Aspergillus flavus strain NRRL 3357." Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ963484 Genomic DNA. Translation: EED46161.1.
RefSeq	XP_002383697.1. XM_002383656.1.
3D structure databases
ProteinModelPortal	B8NTI4.
ModBase	Search...
Protein-protein interaction databases
STRING	5059.CADAFLAP00011562.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFLAT00011562; CADAFLAP00011562; CADAFLAG00011562.
GeneID	7910699.
KEGG	afv:AFLA_098240.
Phylogenomic databases
eggNOG	COG1070.
HOGENOM	HOG000174850.
KO	K00854.
Family and domain databases
InterPro	IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 2 hits. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XKS1_ASPFN

Accession

Primary (citable) accession number: B8NTI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 20, 2010
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program