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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64NucleophilePROSITE-ProRule annotation1
Active sitei419Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:AFLA_051480
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_051480.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003956791 – 755Probable ubiquitin carboxyl-terminal hydrolase creBAdd BLAST755

Interactioni

Subunit structurei

Interacts with creA, creC and qutD.By similarity

Protein-protein interaction databases

STRINGi5059.CADAFLAP00011139.

Structurei

3D structure databases

SMRiB8NSV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 468USPAdd BLAST414

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili581 – 630Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi676 – 681Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000192482.
KOiK11872.
OMAiEMFRNSM.
OrthoDBiEOG092C0UAA.

Family and domain databases

InterProiView protein in InterPro
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
PROSITEiView protein in PROSITE
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B8NSV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFLRSLRR DVGPPTPSVG ATPAKKEPPV PPVTPLEKML QDMGAIREDG
60 70 80 90 100
SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVVNYPTRT PIESLEAALA
110 120 130 140 150
NTLRYQNFAA NLEAEALAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK
160 170 180 190 200
MALQTLPLLE TKNNATSYGM SESLFTSLKD LFESVVASQS RIGIIRPQHF
210 220 230 240 250
LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPEPERSLPP
260 270 280 290 300
AESADSTELS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV
310 320 330 340 350
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI
360 370 380 390 400
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR
410 420 430 440 450
LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF
460 470 480 490 500
FGDRPGLACA YVLFYQETTL EAVMKEQEQE NMDLNTSVAD INDSTLKQNG
510 520 530 540 550
YPLSPGLAHV HSASQIPSPS EPARFSNLQR APTAPPLFPH PEHADSESSP
560 570 580 590 600
ADPSTTASAT PPVPPIPDIH SLPLSPKKSD SHFKKERAKE EKERKANEKE
610 620 630 640 650
KEKQRRRDQE ARIREQRRED AEIRAALEAS KASKAEEDRR HSPDDTKKSS
660 670 680 690 700
HGLSRLKRGS KSFSHRLGKD KENRVSSSSH SATPIAEHPP SRNGASESQQ
710 720 730 740 750
QLPNGQSPGS HGLHTRHTGL DEERDTLKDP KHDRSGHHGK WRSFSLKKKS

FSILS
Length:755
Mass (Da):85,064
Last modified:March 3, 2009 - v1
Checksum:iFA0FB9C8256630C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963483 Genomic DNA. Translation: EED47094.1.
RefSeqiXP_002383274.1. XM_002383233.1.

Genome annotation databases

EnsemblFungiiEED47094; EED47094; AFLA_051480.
GeneIDi7909143.
KEGGiafv:AFLA_051480.

Similar proteinsi

Entry informationi

Entry nameiCREB_ASPFN
AccessioniPrimary (citable) accession number: B8NSV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families