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B8NSV5

- CREB_ASPFN

UniProt

B8NSV5 - CREB_ASPFN

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Protein
Probable ubiquitin carboxyl-terminal hydrolase creB
Gene
creB, AFLA_051480
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Nucleophile By similarity
Active sitei419 – 4191Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. carbon catabolite repression of transcription Source: UniProtKB
  2. ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:AFLA_051480
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395679Add
BLAST

Interactioni

Subunit structurei

Interacts with creA, creC and qutD By similarity.

Protein-protein interaction databases

STRINGi5059.CADAFLAP00011139.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 468414USP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili581 – 63050 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi676 – 6816Poly-Ser

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000192482.
KOiK11872.
OMAiRREHEMF.
OrthoDBiEOG7TF7JV.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8NSV5-1 [UniParc]FASTAAdd to Basket

« Hide

MGSFLRSLRR DVGPPTPSVG ATPAKKEPPV PPVTPLEKML QDMGAIREDG    50
SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVVNYPTRT PIESLEAALA 100
NTLRYQNFAA NLEAEALAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK 150
MALQTLPLLE TKNNATSYGM SESLFTSLKD LFESVVASQS RIGIIRPQHF 200
LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPEPERSLPP 250
AESADSTELS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV 300
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI 350
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR 400
LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF 450
FGDRPGLACA YVLFYQETTL EAVMKEQEQE NMDLNTSVAD INDSTLKQNG 500
YPLSPGLAHV HSASQIPSPS EPARFSNLQR APTAPPLFPH PEHADSESSP 550
ADPSTTASAT PPVPPIPDIH SLPLSPKKSD SHFKKERAKE EKERKANEKE 600
KEKQRRRDQE ARIREQRRED AEIRAALEAS KASKAEEDRR HSPDDTKKSS 650
HGLSRLKRGS KSFSHRLGKD KENRVSSSSH SATPIAEHPP SRNGASESQQ 700
QLPNGQSPGS HGLHTRHTGL DEERDTLKDP KHDRSGHHGK WRSFSLKKKS 750
FSILS 755
Length:755
Mass (Da):85,064
Last modified:March 3, 2009 - v1
Checksum:iFA0FB9C8256630C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963483 Genomic DNA. Translation: EED47094.1.
RefSeqiXP_002383274.1. XM_002383233.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00011139; CADAFLAP00011139; CADAFLAG00011139.
GeneIDi7909143.
KEGGiafv:AFLA_051480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963483 Genomic DNA. Translation: EED47094.1 .
RefSeqi XP_002383274.1. XM_002383233.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00011139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00011139 ; CADAFLAP00011139 ; CADAFLAG00011139 .
GeneIDi 7909143.
KEGGi afv:AFLA_051480.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000192482.
KOi K11872.
OMAi RREHEMF.
OrthoDBi EOG7TF7JV.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiCREB_ASPFN
AccessioniPrimary (citable) accession number: B8NSV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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