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B8NSV5

- CREB_ASPFN

UniProt

B8NSV5 - CREB_ASPFN

Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641NucleophilePROSITE-ProRule annotation
    Active sitei419 – 4191Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. carbon catabolite repression of transcription Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
    Alternative name(s):
    Carbon catabolite repression protein B
    Deubiquitinating enzyme creB
    Ubiquitin thioesterase creB
    Ubiquitin-hydrolyzing enzyme creB
    Ubiquitin-specific-processing protease creB
    Gene namesi
    Name:creB
    ORF Names:AFLA_051480
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 755755Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395679Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with creA, creC and qutD.By similarity

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00011139.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 468414USPAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili581 – 63050Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi676 – 6816Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000192482.
    KOiK11872.
    OMAiRREHEMF.
    OrthoDBiEOG7TF7JV.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8NSV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSFLRSLRR DVGPPTPSVG ATPAKKEPPV PPVTPLEKML QDMGAIREDG    50
    SDKFFGMENY GNTCYCNSIL QCLYYSVPFR EAVVNYPTRT PIESLEAALA 100
    NTLRYQNFAA NLEAEALAEK QKAANAQRPG APPNQPQKPE DKDSPEYKKK 150
    MALQTLPLLE TKNNATSYGM SESLFTSLKD LFESVVASQS RIGIIRPQHF 200
    LDVLRREHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPEPERSLPP 250
    AESADSTELS GSSGSKTPNT TRWVHELFEG TLTSETQCLT CEKVSQRDEV 300
    FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI 350
    KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR 400
    LYELYAVVVH IGGGPYHGHY VAIIKTQDRG WLLFDDEMVE PVDKNYVRNF 450
    FGDRPGLACA YVLFYQETTL EAVMKEQEQE NMDLNTSVAD INDSTLKQNG 500
    YPLSPGLAHV HSASQIPSPS EPARFSNLQR APTAPPLFPH PEHADSESSP 550
    ADPSTTASAT PPVPPIPDIH SLPLSPKKSD SHFKKERAKE EKERKANEKE 600
    KEKQRRRDQE ARIREQRRED AEIRAALEAS KASKAEEDRR HSPDDTKKSS 650
    HGLSRLKRGS KSFSHRLGKD KENRVSSSSH SATPIAEHPP SRNGASESQQ 700
    QLPNGQSPGS HGLHTRHTGL DEERDTLKDP KHDRSGHHGK WRSFSLKKKS 750
    FSILS 755
    Length:755
    Mass (Da):85,064
    Last modified:March 3, 2009 - v1
    Checksum:iFA0FB9C8256630C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963483 Genomic DNA. Translation: EED47094.1.
    RefSeqiXP_002383274.1. XM_002383233.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00011139; CADAFLAP00011139; CADAFLAG00011139.
    GeneIDi7909143.
    KEGGiafv:AFLA_051480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963483 Genomic DNA. Translation: EED47094.1 .
    RefSeqi XP_002383274.1. XM_002383233.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00011139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00011139 ; CADAFLAP00011139 ; CADAFLAG00011139 .
    GeneIDi 7909143.
    KEGGi afv:AFLA_051480.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000192482.
    KOi K11872.
    OMAi RREHEMF.
    OrthoDBi EOG7TF7JV.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiCREB_ASPFN
    AccessioniPrimary (citable) accession number: B8NSV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3