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B8NRX2

- BGLA_ASPFN

UniProt

B8NRX2 - BGLA_ASPFN

Protein

Probable beta-glucosidase A

Gene

bglA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei281 – 2811By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase A (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase A
    Cellobiase A
    Gentiobiase A
    Gene namesi
    Name:bglA
    Synonyms:bgl1
    ORF Names:AFLA_051140
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 861842Probable beta-glucosidase APRO_0000394094Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi543 – 5431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi565 – 5651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi713 – 7131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00011105.

    Structurei

    3D structure databases

    ProteinModelPortaliB8NRX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiAHHSGVG.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8NRX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLGWIEVAA LAAASVVSAK DDLAYSPPFY PSPWADGQGE WAEVYKRAVD    50
    IVSQMTLTEK VNLTTGTGWQ LERCVGQTGS VPRLNIPSLC LQDSPLGIRF 100
    SDYNSAFPAG VNVAATWDKT LAYLRGQAMG EEFSDKGIDV QLGPAAGPLG 150
    AHPDGGRNWE GFSPDPALTG VLFAETIRGI QDAGVIATAK HYIMNEQEHF 200
    RQQPEAAGYG FNVSDSLSSN VDDKTMHELY LWPFADAVRA GVGAVMCSYN 250
    QINNSYGCEN SETLNKLLKA ELGFQGFVMS DWTAHHSGVG AALAGLDMSM 300
    PGDVTFDSGT SFWGANLTVG VLNGTIPQWR VDDMAVRIMA AYYKVGRDTK 350
    YTPPNFSSWT RDEYGFAHNH VSEGAYERVN EFVDVQRDHA DLIRRIGAQS 400
    TVLLKNKGAL PLSRKEKLVA LLGEDAGSNS WGANGCDDRG CDNGTLAMAW 450
    GSGTANFPYL VTPEQAIQNE VLQGRGNVFA VTDSWALDKI AAAARQASVS 500
    LVFVNSDSGE GYLSVDGNEG DRNNITLWKN GDNVVKTAAE NCNNTVVIIH 550
    SVGPVLIDEW YDHPNVTGIL WAGLPGQESG NSIADVLYGR VNPGAKSPFT 600
    WGKTRESYGS PLVKDANNGN GAPQSDFTQG VFIDYRHFDK FNETPIYEFG 650
    YGLSYTTFEL SDLHVQPLNA SRYTPTSGMT EAAKNFGEIG DASEYVYPEG 700
    LERIHEFIYP WINSTDLKAS SDDSNYGWED SKYIPEGATD GSAQPLLPAS 750
    GGAGGNPGLY EDLFRVSVKV KNTGNVAGDE VPQLYVSLGG PNEPKVVLRK 800
    FERIHLAPSQ EAVWTTTLTR RDLANWDVSA QDWTVTPYPK TIYVGNSSRK 850
    LPLQASLPKA Q 861
    Length:861
    Mass (Da):93,415
    Last modified:March 3, 2009 - v1
    Checksum:i5AD246CD78881B27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963483 Genomic DNA. Translation: EED47060.1.
    RefSeqiXP_002383240.1. XM_002383199.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00011105; CADAFLAP00011105; CADAFLAG00011105.
    GeneIDi7909109.
    KEGGiafv:AFLA_051140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963483 Genomic DNA. Translation: EED47060.1 .
    RefSeqi XP_002383240.1. XM_002383199.1.

    3D structure databases

    ProteinModelPortali B8NRX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00011105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00011105 ; CADAFLAP00011105 ; CADAFLAG00011105 .
    GeneIDi 7909109.
    KEGGi afv:AFLA_051140.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi AHHSGVG.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR019800. Glyco_hydro_3_AS.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiBGLA_ASPFN
    AccessioniPrimary (citable) accession number: B8NRX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3