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B8NP78

- MANBA_ASPFN

UniProt

B8NP78 - MANBA_ASPFN

Protein

Beta-mannosidase A

Gene

mndA

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei462 – 4621Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase A (EC:3.2.1.25)
    Alternative name(s):
    Mannanase A
    Short name:
    Mannase A
    Gene namesi
    Name:mndA
    ORF Names:AFLA_128610
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 914894Beta-mannosidase APRO_0000394645Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi641 – 6411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi744 – 7441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi773 – 7731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi784 – 7841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00009919.

    Structurei

    3D structure databases

    ProteinModelPortaliB8NP78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000216059.
    KOiK01192.
    OMAiCHATQLF.
    OrthoDBiEOG78D7TH.

    Family and domain databases

    Gene3Di2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8NP78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFTATAAAL VASSIPATLG QHVRDLSNEK WTLSSDALNH TVPGNLPSHA    50
    HLDLLKAGVI DDPYHGLNDF NLRWIPESNW TYTTDKIKDL MPIEFCGKYV 100
    ASTNNQYRQY SFDVSQILEG CNEDPILKID FGSAPNIVNA IAEDRNSPVW 150
    PDGIQQTYEY PNRWFMRKEQ SDFGWDWGPA FAPAGPWKPA YIVQLPKAQN 200
    IHVLNTDLDI YRKGQINHLP PDQSQPWVVN ASIDFVGSLP PNPSMSIEFK 250
    DTKSGEILTS KRIGNVTVSG NSVTGVTVLG GVTPKLWWPL GLGDQNLYNI 300
    TVTVTGHQNQ TLAHVTKRTG FRTIFLNQRN ITDAQLAQGI APGANWHFEV 350
    NGHEFYAKGS NIIPPDAFWP RVTEARMARL FDAVVAGNQN MLRVWSSGIY 400
    LHDFIYDLAD ERGILLWSEF EFSDALYPVD DAFLDNIAAE VVYNVRRVNH 450
    HPSLALWAGG NEIESLMLPT VERKAPEEYA KYVGEYEKLY ISLILPLVYQ 500
    NTRSITYSPS STTEGYLDVD LSAPVPMVER YHNTTPGSYY GDTDFYNYDS 550
    SVSFNSHVYP VGRFANEFGY HSMPSLQTWQ QAVDPEDLHF NSTTVMLRNH 600
    HYPAGGTFTD NFHNTSLGMG EMTIAVQRYY PIPNKLDSVA NFSAWCHATQ 650
    LFQADMYKSE IQFYRRGSGM PERQLGSLYW QLEDIWQAPS WAGIEYGGRW 700
    KVLHYVSRDI YQRIIVSPFW NYTTGDLDLY VTSDLWESAK GKVNLTWLDL 750
    SGTPLPHNAG TPGSVPFNVG ALNTTKIYST NIKNLTLPNP KDAILVLSLS 800
    GEGHLPNSDK KTTFTHQNHF TPVFPKDLAL VDPGLELSYN TKSKTFTVEA 850
    KSGVSLYTWL DYPADVVGYF DENAFVLLPG QKKEIGFTVQ EDNTDGKWVQ 900
    GVTVQSLWNQ TLEK 914
    Length:914
    Mass (Da):102,929
    Last modified:March 3, 2009 - v1
    Checksum:iF6DAC075C591E64B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963481 Genomic DNA. Translation: EED48638.1.
    RefSeqiXP_002382054.1. XM_002382013.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00009919; CADAFLAP00009919; CADAFLAG00009919.
    GeneIDi7921726.
    KEGGiafv:AFLA_128610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963481 Genomic DNA. Translation: EED48638.1 .
    RefSeqi XP_002382054.1. XM_002382013.1.

    3D structure databases

    ProteinModelPortali B8NP78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00009919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00009919 ; CADAFLAP00009919 ; CADAFLAG00009919 .
    GeneIDi 7921726.
    KEGGi afv:AFLA_128610.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000216059.
    KOi K01192.
    OMAi CHATQLF.
    OrthoDBi EOG78D7TH.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    Gene3Di 2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiMANBA_ASPFN
    AccessioniPrimary (citable) accession number: B8NP78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3