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B8NNK9

- EXGD_ASPFN

UniProt

B8NNK9 - EXGD_ASPFN

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Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei597 – 5971Proton donorBy similarity
Active sitei702 – 7021NucleophileBy similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AFLA_129100
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 297297CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini319 – 831513ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 831831Probable glucan 1,3-beta-glucosidase DPRO_0000395163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi376 – 3761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi610 – 6101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi636 – 6361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi689 – 6891N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00009968.

Structurei

3D structure databases

ProteinModelPortaliB8NNK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 161156Arg-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiNIITHYG.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B8NNK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSHSRSRDR YRGERDPSRR YREVYDDDDD DDFDYHPRER RRYRRDDYQH
60 70 80 90 100
DIRSHESPNY NDDLNEYDAA AEDPAVPLRS HDVEGRRRER SRAGESPIAS
110 120 130 140 150
PSRRDRNRGG EEYRRHGTYG DGGSPTRAMR DRRHRSRDGQ RARPRDMDRE
160 170 180 190 200
ARRQRRRERA RGAAAMKHKS SDSTNSGSHL LSADALAKLR SHYDEEDQRE
210 220 230 240 250
RSQEQEQPRL ESKRQRKRPI VGDEPQALAP FPDETPRGQS KGRIVSGAYL
260 270 280 290 300
EEGHPEMEVR HRGGGGPAME ARWRKEGNWD GTMEGSDAQP PFWKRKKWWI
310 320 330 340 350
VIGVLVVVLA IVIPVAVVMS KKHGHDDDKS GSSSSVDNSD SPYISSLDGL
360 370 380 390 400
SHDSIPESAQ GSILDPWTWY DTRDFNLTFT NETVGGLPIM GLNSTWDDST
410 420 430 440 450
RPNDNVPPLN ESFPYGSQPI RGVNLGGWLS IEPFIVPSLF ENYSSKDRII
460 470 480 490 500
DEYTLCKKLG SSAASTIEKH YADFISEQDF IDMRDAGLDH VRIQFSYWAV
510 520 530 540 550
TTYDDDPYVA KISWRYLLRA IEYCRKYGLR VNLDPHGIPG SQNGWNHSGR
560 570 580 590 600
EGVIGWLNGT DGQLNRQRSL DFHNQISQFF AQPRYKNVVT IYGLVNEPLM
610 620 630 640 650
LSLPVEDVLN WTTDATKLVQ KNGISAYVTV HDGFLNLSKW KQMLKDRPDR
660 670 680 690 700
MFLDTHQYTI FNTGQIVLNH TDRVKLICND WYNMIKEINT TSAGWGPTIC
710 720 730 740 750
GEWSQADTDC AQYLNNVGRG TRWEGTFAIG DSTVYCPTAD TGPTCSCASA
760 770 780 790 800
NAPPADYSDG YKKFLQTYAE AQMSAFGTAQ GWFYWTWHTE SAAQWSYKTA
810 820 830
WKNGYMPKKA YAPDFKCGDD IPSFGDLPEY Y
Length:831
Mass (Da):95,079
Last modified:March 3, 2009 - v1
Checksum:i9898B3C61F07541B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963481 Genomic DNA. Translation: EED48687.1.
RefSeqiXP_002382103.1. XM_002382062.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00009968; CADAFLAP00009968; CADAFLAG00009968.
GeneIDi7921775.
KEGGiafv:AFLA_129100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963481 Genomic DNA. Translation: EED48687.1 .
RefSeqi XP_002382103.1. XM_002382062.1.

3D structure databases

ProteinModelPortali B8NNK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00009968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00009968 ; CADAFLAP00009968 ; CADAFLAG00009968 .
GeneIDi 7921775.
KEGGi afv:AFLA_129100.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi NIITHYG.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiEXGD_ASPFN
AccessioniPrimary (citable) accession number: B8NNK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3