B8NC10 (AMPP3_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase pepP
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	pepP
ORF Names:	AFLA_047350

Organism

Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]

Taxonomic identifier

332952 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus flavus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Probable Xaa-Pro aminopeptidase pepP		PRO_0000411864
Sites
	Metal binding	265	1	Manganese 2 By similarity
	Metal binding	276	1	Manganese 1 By similarity
	Metal binding	276	1	Manganese 2 By similarity
	Metal binding	399	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8NC10 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 1465F938815F2B72	FASTA	467	51,608
	10 20 30 40 50 60 MATVDDILTG KYPAKSHARR VAQLLQAHHG QGAPGVIYLE AQKTRLIEDN DEPMPFRQRR 70 80 90 100 110 120 FFYYLSGCSL PDSYLIYDIN ADKLTLFIPP IDAEEVIWSG LPLSADEAMK LYDVDCVLAA 130 140 150 160 170 180 TEVNATLRSI GSAYGGNAVA FAIADQVSSG AEFQGFAETK LSVLKEAIEK ARVVKDEYEI 190 200 210 220 230 240 ALLRKANDIS AKAHIAAIRA SKTAVNEREI EGAFIATCIA HGAREQSYHP IVACGANGAT 250 260 270 280 290 300 LHYGKNDDDL TDPATKQRKN NILIDAGGEY RAYCSDITRV FPLGGSFTKE TRQIYEIVLQ 310 320 330 340 350 360 MQLECIAMLK GDVQWEDVHA HAHRVAIKGL LALGILSGSE DELFEKRISV AFFPHGLGHY 370 380 390 400 410 420 LGMDTHDTGG NPNYGDKDTM FKYLRVRGRL PVGSVITVEP GIYFCRFIID PYTQSPELGK 430 440 450 460 YINTTVLERY WMVGGVRIED NIHITKDGHE NLTTAPKAIE EMESLAL

References

[1]

"Genome sequence of Aspergillus flavus strain NRRL 3357." Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EQ963476 Genomic DNA. Translation: EED53033.1.
RefSeq	XP_002378197.1. XM_002378156.1.
3D structure databases
ProteinModelPortal	B8NC10.
ModBase	Search...
Protein-protein interaction databases
STRING	5059.CADAFLAP00006062.
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFLAT00006062; CADAFLAP00006062; CADAFLAG00006062.
GeneID	7914720.
KEGG	afv:AFLA_047350.
Phylogenomic databases
HOGENOM	HOG000008763.
KO	K14213.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP3_ASPFN

Accession

Primary (citable) accession number: B8NC10

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program