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B8NB34 (B8NB34_ASPFN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin By similarity. PIRNR PIRNR000241 RuleBase RU004455

Catalytic activity

Urate + O2 + H2O = 5-hydroxyisourate + H2O2. PIRNR PIRNR000241 RuleBase RU004455

Pathway

Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. PIRNR PIRNR000241

Subcellular location

Peroxisome By similarity PIRNR PIRNR000241.

Sequence similarities

Belongs to the uricase family. PIRNR PIRNR000241 RuleBase RU004455

Ontologies

Keywords
   Biological processPurine metabolism PIRNR PIRNR000241 RuleBase RU004455
   Cellular componentPeroxisome PIRNR PIRNR000241
   Molecular functionOxidoreductase PIRNR PIRNR000241 RuleBase RU004455
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleobase metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

urate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurate oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region228 – 2292Substrate binding By similarity PIRSR PIRSR000241-2
Motif300 – 3023Microbody targeting signal (Potential) By similarity PIRSR PIRSR000241-3

Sites

Active site1771Charge relay system By similarity PIRSR PIRSR000241-1
Active site2291Charge relay system By similarity PIRSR PIRSR000241-1
Binding site1771Substrate By similarity PIRSR PIRSR000241-2

Sequences

Sequence LengthMass (Da)Tools
B8NB34 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: B4FAD4ED4EC121AE

FASTA30234,241
        10         20         30         40         50         60 
MSAVKAARYG KDNVRVYKVH KDEKTGVQTV YEMTVCVLLE GEIETSYTKA DNSVIVATDS 

        70         80         90        100        110        120 
IKNTIYITAK QNPVTPPELF GSILGTHFIE KYNHIHAAHV NIVCHRWTRM DIDGKPHPHS 

       130        140        150        160        170        180 
FIRDSEEKRN VQVDVVEGKG IDIKSSLSGL TVLKSTNSQF WGFLRDEYTT LKETWDRILS 

       190        200        210        220        230        240 
TDVDATWQWK NFSGLQEVRS HVPKFDATWA TAREVTLKTF AEDNSASVQA TMYKMAEQIL 

       250        260        270        280        290        300 
ARQQLIETVE YSLPNKHYFE IDLSWHKGLQ NTGKNAEVFA PQSDPNGLIK CTVGRSSLKS 


KL

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References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		EQ963476 Genomic DNA. Translation: EED52707.1.
RefSeqXP_002377871.1. XM_002377830.1.

3D structure databases

ProteinModelPortalB8NB34.
SMRB8NB34. Positions 3-300.
ModBaseSearch...

Protein-protein interaction databases

STRING5059.CADAFLAP00005736.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00005736; CADAFLAP00005736; CADAFLAG00005736.
GeneID7916167.
KEGGafv:AFLA_044090.

Phylogenomic databases

KOK00365.

Enzyme and pathway databases

UniPathwayUPA00394; UER00650.

Family and domain databases

Gene3D3.10.270.10. 1 hit.
InterProIPR002042. Uricase.
IPR019842. Uricase_CS.
[Graphical view]
PANTHERPTHR10395:SF1. PTHR10395:SF1. 1 hit.
PfamPF01014. Uricase. 2 hits.
[Graphical view]
PIRSFPIRSF000241. Urate_oxidase. 1 hit.
PRINTSPR00093. URICASE.
TIGRFAMsTIGR03383. urate_oxi. 1 hit.
PROSITEPS00366. URICASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8NB34_ASPFN
AccessionPrimary (citable) accession number: B8NB34
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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