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B8N970

- DPP4_ASPFN

UniProt

B8N970 - DPP4_ASPFN

Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei618 – 6181Charge relay systemBy similarity
    Active sitei695 – 6951Charge relay systemBy similarity
    Active sitei730 – 7301Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Dipeptidyl peptidase IV
    Short name:
    DPP IV
    Short name:
    DppIV
    Gene namesi
    Name:dpp4
    ORF Names:AFLA_110160
    OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
    Taxonomic identifieri332952 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001875: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 771755Probable dipeptidyl peptidase 4PRO_0000397811Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5059.CADAFLAP00004750.

    Structurei

    3D structure databases

    ProteinModelPortaliB8N970.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1506.
    HOGENOMiHOG000189891.
    KOiK01278.
    OMAiWAVNYTK.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B8N970-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYSKLLLLL VSVVQALDVP RKPHAPTGEG SKRLTFNETV VKQAITPTSR    50
    SVQWLSGAED GSYVYAAEDG SLTIENIVTN ESRTLIPADK IPTGKEAFNY 100
    WIHPDLSSVL WASNHTKQYR HSFFADYYVQ DVESLKSVPL MPDQEGDIQY 150
    AQWSPVGNTI AFVRENDLYV WDNGTVTRIT DDGGPDMFHG VPDWIYEEEI 200
    LGDRYALWFS PDGEYLAYLS FNETGVPTYT VQYYMDNQEI APAYPWELKI 250
    RYPKVSQTNP TVTLSLLNIA SKEVKQAPID AFESTDLIIG EVAWLTDTHT 300
    TVAAKAFNRV QDQQKVVAVD TASNKATVIS DRDGTDGWLD NLLSMKYIGP 350
    IKPSDKDAYY IDISDHSGWA HLYLFPVSGG EPIPLTKGDW EVTSILSIDQ 400
    ERQLVYYLST QHHSTERHLY SVSYSTFAVT PLVDDTVAAY WSASFSANSG 450
    YYILTYGGPD VPYQELYTTN STKPLRTITD NAKVLEQIKD YALPNITYFE 500
    LPLPSGETLN VMQRLPPGFS PDKKYPILFT PYGGPGAQEV TKRWQALNFK 550
    AYVASDSELE YVTWTVDNRG TGFKGRKFRS AVTRQLGLLE AEDQIYAAQQ 600
    AANIPWIDAD HIGIWGWSFG GYLTSKVLEK DSGAFTLGVI TAPVSDWRFY 650
    DSMYTERYMK TLSTNEEGYE TSAVRKTDGF KNVEGGFLIQ HGTGDDNVHF 700
    QNSAALVDLL MGDGVSPEKL HSQWFTDSDH GISYHGGGVF LYKQLARKLY 750
    QEKNRQTQVL MHQWTKKDLE E 771
    Length:771
    Mass (Da):86,875
    Last modified:March 3, 2009 - v1
    Checksum:i25A9C096B0258A7B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963475 Genomic DNA. Translation: EED53639.1.
    RefSeqiXP_002376885.1. XM_002376844.1.

    Genome annotation databases

    EnsemblFungiiCADAFLAT00004750; CADAFLAP00004750; CADAFLAG00004750.
    GeneIDi7914778.
    KEGGiafv:AFLA_110160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EQ963475 Genomic DNA. Translation: EED53639.1 .
    RefSeqi XP_002376885.1. XM_002376844.1.

    3D structure databases

    ProteinModelPortali B8N970.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5059.CADAFLAP00004750.

    Protein family/group databases

    MEROPSi S09.008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFLAT00004750 ; CADAFLAP00004750 ; CADAFLAG00004750 .
    GeneIDi 7914778.
    KEGGi afv:AFLA_110160.

    Phylogenomic databases

    eggNOGi COG1506.
    HOGENOMi HOG000189891.
    KOi K01278.
    OMAi WAVNYTK.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
      Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

    Entry informationi

    Entry nameiDPP4_ASPFN
    AccessioniPrimary (citable) accession number: B8N970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3