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Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei618 – 6181Charge relay systemBy similarity
Active sitei695 – 6951Charge relay systemBy similarity
Active sitei730 – 7301Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AFLA_110160
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875 Componenti: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 771755Probable dipeptidyl peptidase 4PRO_0000397811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi470 – 4701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi495 – 4951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5059.CADAFLAP00004750.

Structurei

3D structure databases

ProteinModelPortaliB8N970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiVQYFAWA.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8N970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYSKLLLLL VSVVQALDVP RKPHAPTGEG SKRLTFNETV VKQAITPTSR
60 70 80 90 100
SVQWLSGAED GSYVYAAEDG SLTIENIVTN ESRTLIPADK IPTGKEAFNY
110 120 130 140 150
WIHPDLSSVL WASNHTKQYR HSFFADYYVQ DVESLKSVPL MPDQEGDIQY
160 170 180 190 200
AQWSPVGNTI AFVRENDLYV WDNGTVTRIT DDGGPDMFHG VPDWIYEEEI
210 220 230 240 250
LGDRYALWFS PDGEYLAYLS FNETGVPTYT VQYYMDNQEI APAYPWELKI
260 270 280 290 300
RYPKVSQTNP TVTLSLLNIA SKEVKQAPID AFESTDLIIG EVAWLTDTHT
310 320 330 340 350
TVAAKAFNRV QDQQKVVAVD TASNKATVIS DRDGTDGWLD NLLSMKYIGP
360 370 380 390 400
IKPSDKDAYY IDISDHSGWA HLYLFPVSGG EPIPLTKGDW EVTSILSIDQ
410 420 430 440 450
ERQLVYYLST QHHSTERHLY SVSYSTFAVT PLVDDTVAAY WSASFSANSG
460 470 480 490 500
YYILTYGGPD VPYQELYTTN STKPLRTITD NAKVLEQIKD YALPNITYFE
510 520 530 540 550
LPLPSGETLN VMQRLPPGFS PDKKYPILFT PYGGPGAQEV TKRWQALNFK
560 570 580 590 600
AYVASDSELE YVTWTVDNRG TGFKGRKFRS AVTRQLGLLE AEDQIYAAQQ
610 620 630 640 650
AANIPWIDAD HIGIWGWSFG GYLTSKVLEK DSGAFTLGVI TAPVSDWRFY
660 670 680 690 700
DSMYTERYMK TLSTNEEGYE TSAVRKTDGF KNVEGGFLIQ HGTGDDNVHF
710 720 730 740 750
QNSAALVDLL MGDGVSPEKL HSQWFTDSDH GISYHGGGVF LYKQLARKLY
760 770
QEKNRQTQVL MHQWTKKDLE E
Length:771
Mass (Da):86,875
Last modified:March 3, 2009 - v1
Checksum:i25A9C096B0258A7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963475 Genomic DNA. Translation: EED53639.1.
RefSeqiXP_002376885.1. XM_002376844.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00004750; CADAFLAP00004750; CADAFLAG00004750.
GeneIDi7914778.
KEGGiafv:AFLA_110160.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963475 Genomic DNA. Translation: EED53639.1.
RefSeqiXP_002376885.1. XM_002376844.1.

3D structure databases

ProteinModelPortaliB8N970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5059.CADAFLAP00004750.

Protein family/group databases

MEROPSiS09.008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFLAT00004750; CADAFLAP00004750; CADAFLAG00004750.
GeneIDi7914778.
KEGGiafv:AFLA_110160.

Phylogenomic databases

eggNOGiCOG1506.
HOGENOMiHOG000189891.
KOiK01278.
OMAiVQYFAWA.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiDPP4_ASPFN
AccessioniPrimary (citable) accession number: B8N970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 3, 2009
Last modified: January 7, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.