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B8N970 (DPP4_ASPFN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl peptidase 4

EC=3.4.14.5
Alternative name(s):
Dipeptidyl peptidase IV
Short name=DPP IV
Short name=DppIV
Gene names
Name:dpp4
ORF Names:AFLA_110160
OrganismAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) [Complete proteome]
Taxonomic identifier332952 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 771755Probable dipeptidyl peptidase 4
PRO_0000397811

Sites

Active site6181Charge relay system By similarity
Active site6951Charge relay system By similarity
Active site7301Charge relay system By similarity

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation4951N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B8N970 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 25A9C096B0258A7B

FASTA77186,875
        10         20         30         40         50         60 
MKYSKLLLLL VSVVQALDVP RKPHAPTGEG SKRLTFNETV VKQAITPTSR SVQWLSGAED 

        70         80         90        100        110        120 
GSYVYAAEDG SLTIENIVTN ESRTLIPADK IPTGKEAFNY WIHPDLSSVL WASNHTKQYR 

       130        140        150        160        170        180 
HSFFADYYVQ DVESLKSVPL MPDQEGDIQY AQWSPVGNTI AFVRENDLYV WDNGTVTRIT 

       190        200        210        220        230        240 
DDGGPDMFHG VPDWIYEEEI LGDRYALWFS PDGEYLAYLS FNETGVPTYT VQYYMDNQEI 

       250        260        270        280        290        300 
APAYPWELKI RYPKVSQTNP TVTLSLLNIA SKEVKQAPID AFESTDLIIG EVAWLTDTHT 

       310        320        330        340        350        360 
TVAAKAFNRV QDQQKVVAVD TASNKATVIS DRDGTDGWLD NLLSMKYIGP IKPSDKDAYY 

       370        380        390        400        410        420 
IDISDHSGWA HLYLFPVSGG EPIPLTKGDW EVTSILSIDQ ERQLVYYLST QHHSTERHLY 

       430        440        450        460        470        480 
SVSYSTFAVT PLVDDTVAAY WSASFSANSG YYILTYGGPD VPYQELYTTN STKPLRTITD 

       490        500        510        520        530        540 
NAKVLEQIKD YALPNITYFE LPLPSGETLN VMQRLPPGFS PDKKYPILFT PYGGPGAQEV 

       550        560        570        580        590        600 
TKRWQALNFK AYVASDSELE YVTWTVDNRG TGFKGRKFRS AVTRQLGLLE AEDQIYAAQQ 

       610        620        630        640        650        660 
AANIPWIDAD HIGIWGWSFG GYLTSKVLEK DSGAFTLGVI TAPVSDWRFY DSMYTERYMK 

       670        680        690        700        710        720 
TLSTNEEGYE TSAVRKTDGF KNVEGGFLIQ HGTGDDNVHF QNSAALVDLL MGDGVSPEKL 

       730        740        750        760        770 
HSQWFTDSDH GISYHGGGVF LYKQLARKLY QEKNRQTQVL MHQWTKKDLE E 

« Hide

References

[1]"Genome sequence of Aspergillus flavus strain NRRL 3357."
Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EQ963475 Genomic DNA. Translation: EED53639.1.
RefSeqXP_002376885.1. XM_002376844.1.

3D structure databases

ProteinModelPortalB8N970.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5059.CADAFLAP00004750.

Protein family/group databases

MEROPSS09.008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFLAT00004750; CADAFLAP00004750; CADAFLAG00004750.
GeneID7914778.
KEGGafv:AFLA_110160.

Phylogenomic databases

eggNOGCOG1506.
HOGENOMHOG000189891.
KOK01278.
OMAWAVNYTK.
OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDPP4_ASPFN
AccessionPrimary (citable) accession number: B8N970
Entry history
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries