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B8N7S7

- EGLX_ASPFN

UniProt

B8N7S7 - EGLX_ASPFN

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Protein
Probable endo-1,3(4)-beta-glucanase AFLA_105200
Gene
AFLA_105200
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates By similarity.

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441Nucleophile By similarity
Active sitei149 – 1491Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase AFLA_105200 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase AFLA_105200
Gene namesi
ORF Names:AFLA_105200
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 644620Probable endo-1,3(4)-beta-glucanase AFLA_105200
PRO_0000395086Add
BLAST
Propeptidei645 – 66723Removed in mature form Reviewed prediction
PRO_0000395087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Lipidationi644 – 6441GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi583 – 61533Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OMAiSCVNYVA.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8N7S7-1 [UniParc]FASTAAdd to Basket

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MSSSSFVWTV GSIALSSLIT PTIADGSGSR YQLTEAWQGE KFLDHFKFFS    50
GSDPTNGFVT YANQSYAESS GLIEVTESGS FYMGVDYKTK LSPNGPGRDS 100
VRIESKEYYD EGLYIIDLQH MPGSVCGTWP AFWSVGPNWP YDGEIDIIEG 150
VNKHEANEIV LHTSGSCSLS SENDMSGTMS SSECGESSGT IGCVVKGQTG 200
TSGAPFNEKN GGVYAMEWTS SFVKIWYFAR SEIPQSITEG NPDTTAFGTP 250
MAHLQGTCDF GERFKSQKFI LDTTFCGDWA GGVFGDSGCP VSDPSNPIQS 300
CVNYVAENPA AFKEAYWEIN YIKLFQTGTG HSTASIASQA ETATAVVSKT 350
VDSVPSVTST PILETTAPAP ETVSAEAPAT SSAVPEPANP QTSVAGAETT 400
AAPAPSPETT AAPASPSSDD SEGADAVSET TIYVTETTTI CGASTQKGTI 450
QTIGGGETEV SPASSTVESA ATPAAPTPTS QEPVASLPGT TVNDGTPVPT 500
DVSPETPAEE TAGESGAPTP SAEQPEKPQP AATSIETGIV PPPVSNPAPT 550
EQGTPEGASP VDATESRHVP DEPAPTSAAP IRSPSPSSWT ISSSSRVALS 600
SSFASTTSSA SRTTSATKEA TAPTETDSGA STGTNPESPV FTAGASKSVG 650
ISGLAGIVCG IAMAMLA 667
Length:667
Mass (Da):68,433
Last modified:March 3, 2009 - v1
Checksum:i6FA9DBFF4C651501
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963475 Genomic DNA. Translation: EED53146.1.
RefSeqiXP_002376392.1. XM_002376351.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00004257; CADAFLAP00004257; CADAFLAG00004257.
GeneIDi7922059.
KEGGiafv:AFLA_105200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963475 Genomic DNA. Translation: EED53146.1 .
RefSeqi XP_002376392.1. XM_002376351.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00004257 ; CADAFLAP00004257 ; CADAFLAG00004257 .
GeneIDi 7922059.
KEGGi afv:AFLA_105200.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OMAi SCVNYVA.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000757. Glyco_hydro_16.
[Graphical view ]
Pfami PF00722. Glyco_hydro_16. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiEGLX_ASPFN
AccessioniPrimary (citable) accession number: B8N7S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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