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Protein

Probable beta-glucosidase M

Gene

bglM

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei287By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase M (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase M
Cellobiase M
Gentiobiase M
Gene namesi
Name:bglM
ORF Names:AFLA_014190
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_014190.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039490520 – 768Probable beta-glucosidase MAdd BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Glycosylationi543N-linked (GlcNAc...)Sequence analysis1
Glycosylationi651N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8N5S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215.
KOiK05349.
OMAiAWASAYE.
OrthoDBiEOG092C0ZJY.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 2 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8N5S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAIAGLTGF LAGVSLSYAA PTQENITSDA YFYGQSPAVY PSPEGTGSGA
60 70 80 90 100
WASAYEKAKA FVANLTPEEK VNLTAGTDAD NGCSGNIPAI PRLNFPGLCV
110 120 130 140 150
SDAGNGLRST DHVNAWSSGI HTGASWNKDL AQKRGLHMGS EYHKKGVNVL
160 170 180 190 200
LGPVVGPLGR IAEGGRNWEG FSVDPYHSGL LVYETIRGIQ AAGVGTSTKH
210 220 230 240 250
YIANEQETNR NPESTDGIDV AAVSSNIDDK TMHELYLWPF QDVVRAGSVS
260 270 280 290 300
IMCSYQRINN SYGCQNSKTL NGLLKTELGF QGYVMTDWGA QHGGIASSNA
310 320 330 340 350
GLDMVMPSST LWNSNLTDAI ANGTMEASRL DDMATRIIAS WYQMNQDAGF
360 370 380 390 400
PSPGIGMPAD VYAPHQAIIG KSSDSRKVLL QSAIEGHVLV KNKNNTLPLK
410 420 430 440 450
SPEMISVFGY DAKGPDSLGF ALEWLSYSPA IQPNHTLIVG GGSGGNSPAY
460 470 480 490 500
ISAPLDALQQ QVIEDGSSIL WNISAQDPEV DPNTDACLVF INSYATEGYD
510 520 530 540 550
RAGLVDEGSD ELVTNVASKC SNTIVTIHNA GIRLVNNWID HENVTAVIFA
560 570 580 590 600
HLPGQDSGRA LVELLYGRSN PSGKLPYTVA KNADDYGALL HPKLPEGQYG
610 620 630 640 650
LFPQDDFSEG VYIDYRAFDK QGIEPQFEFG FGLSYTTFDY SGLNIGQVSD
660 670 680 690 700
NSTSRYPPSA AIQEGGNPHL WDVILRVSVD ITNSGPVAGD EVAQLYVGIP
710 720 730 740 750
NGPVRQLRGF EKVNIPVGQT VTVEFALGRR DLSTWDVVAQ EWLLQSGTYQ
760
VYVGRSSRDL PLQGEFTI
Length:768
Mass (Da):82,429
Last modified:March 3, 2009 - v1
Checksum:i1881AC77816F1F05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963474 Genomic DNA. Translation: EED54167.1.
RefSeqiXP_002375439.1. XM_002375398.1.

Genome annotation databases

EnsemblFungiiEED54167; EED54167; AFLA_014190.
GeneIDi7915042.
KEGGiafv:AFLA_014190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963474 Genomic DNA. Translation: EED54167.1.
RefSeqiXP_002375439.1. XM_002375398.1.

3D structure databases

ProteinModelPortaliB8N5S6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED54167; EED54167; AFLA_014190.
GeneIDi7915042.
KEGGiafv:AFLA_014190.

Organism-specific databases

EuPathDBiFungiDB:AFLA_014190.

Phylogenomic databases

HOGENOMiHOG000031215.
KOiK05349.
OMAiAWASAYE.
OrthoDBiEOG092C0ZJY.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 2 hits.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM01217. Fn3_like. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiBGLM_ASPFN
AccessioniPrimary (citable) accession number: B8N5S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.