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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei128Substrate; via amide nitrogenBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1
Active sitei188Proton donorSequence analysis1
Binding sitei251SubstrateBy similarity1
Active sitei287NucleophileSequence analysis1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:AFLA_037600
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001875 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AFLA_037600.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000039523624 – 984Probable beta-galactosidase CAdd BLAST961

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi421N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1
Glycosylationi602N-linked (GlcNAc...)Sequence analysis1
Glycosylationi677N-linked (GlcNAc...)Sequence analysis1
Glycosylationi715N-linked (GlcNAc...)Sequence analysis1
Glycosylationi720N-linked (GlcNAc...)Sequence analysis1
Glycosylationi759N-linked (GlcNAc...)Sequence analysis1
Glycosylationi805N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB8N2I5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8N2I5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSFIYLV WLALLTGTPQ VSATDNGKTS DVAWDKYSLS VKGERLFVFS
60 70 80 90 100
GEFHYQRLPV PELWLDVFQK LRANGFNTIS VYFFWSYHSA SEDVFDFTTG
110 120 130 140 150
AHDIQRLFDY AKQAGLYVIA RAGPYCNAET SAGGFALWAA NGQMGSERTS
160 170 180 190 200
DEAYYKKWKP WILEVGKIIA ANQITNGGPV ILNQHENELQ ETTYDSNDTK
210 220 230 240 250
VIYMEQVAKA FEEAGVVVPS SHNEKGMRTV SWSTDYKNVG GAVNVYGLDS
260 270 280 290 300
YPGSLSCANP NSGFNLLRTY YQWFQNYSYT QPEYLAEFEG GWFQPWGGSF
310 320 330 340 350
YDSCASELSP EFADVYYKNN IGSRVTLHNI YMTFGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYGSPLRET REIRDKLKQT KLLGLFTRVS KDLLKTYMEG NGTSYTSDDS
410 420 430 440 450
IYTWALRNPD SDAGFYVVAH NTSSSREVTT FSLNITTSAG ALTIPDIELD
460 470 480 490 500
GRQSKIIVTD YSIGSESSLL YSSAEVLTYA TLDVDVLVFY LNAGQKGAFV
510 520 530 540 550
FKDAPADLKY QTYGNSNLSA LETSQGTQYS YTQGEGVTAV KFSNGVLVYL
560 570 580 590 600
LDKETAWNFF APPTVSSPTV APNEHILVFG PYLVRGASIK HDTVEIVGDN
610 620 630 640 650
SNSTSIEIYT GDEHVKKVSW NGNLIDTRAT AYGSLIGTVP GAEDIEISLP
660 670 680 690 700
SLSSWKAQDT LPEISPDYDD SRWTICNKTT SVNSVAPLSL PVLYSGDYGY
710 720 730 740 750
HTGTKIYRGR FDGQNATGAN VTVQNGVAAG WAAWLNGAYV GGFSGDPDKV
760 770 780 790 800
ASWEVLKFNH SSLRSRDNVL TIITDYTGHD QNSQKPIGTQ NPRGIMGATL
810 820 830 840 850
IGGGNFTLWR IQGNAGGEKN IDPVRGPMNE GGLYGERMGW HLPGYQVPES
860 870 880 890 900
ALDSSPLEGV SGAEGRFYTT SFQLDLEEDL DVPIGLQLSA PAGTEAVVQI
910 920 930 940 950
FMNGYQFGHY LPHIGPQSLF PFPPGVIYNR GQNSLAISMW ALTDAGARLE
960 970 980
QVELKAYAKY RSGFDFNRDW TYLQPGWKDR TEYA
Length:984
Mass (Da):108,670
Last modified:March 3, 2009 - v1
Checksum:i3E91614086ACDEB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963473 Genomic DNA. Translation: EED56486.1.
RefSeqiXP_002375268.1. XM_002375227.1.

Genome annotation databases

EnsemblFungiiEED56486; EED56486; AFLA_037600.
GeneIDi7919723.
KEGGiafv:AFLA_037600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ963473 Genomic DNA. Translation: EED56486.1.
RefSeqiXP_002375268.1. XM_002375227.1.

3D structure databases

ProteinModelPortaliB8N2I5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEED56486; EED56486; AFLA_037600.
GeneIDi7919723.
KEGGiafv:AFLA_037600.

Organism-specific databases

EuPathDBiFungiDB:AFLA_037600.

Phylogenomic databases

HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGALC_ASPFN
AccessioniPrimary (citable) accession number: B8N2I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.