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B8N151

- EXGA_ASPFN

UniProt

B8N151 - EXGA_ASPFN

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Protein

Probable glucan 1,3-beta-glucosidase A

Gene
exgA, exg1, AFLA_028260
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei199 – 1991Proton donor By similarity
Active sitei298 – 2981Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:AFLA_028260
OrganismiAspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Taxonomic identifieri332952 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001875: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed predictionAdd
BLAST
Chaini15 – 405391Probable glucan 1,3-beta-glucosidase APRO_0000393529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi280 ↔ 405 By similarity
Disulfide bondi306 ↔ 332 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi5059.CADAFLAP00002201.

Structurei

3D structure databases

ProteinModelPortaliB8N151.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiQYPNICG.
OrthoDBiEOG7JT75H.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B8N151-1 [UniParc]FASTAAdd to Basket

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MLPLLLCIVP YCWSSRLDPR ASSFDYNGEK VRGVNLGGWL VLEPWITPSI    50
FDAAGAEAVD EWSLTKILGK EEAEARLSAH WKSFVSAGDF QRMADAGLNH 100
VRIPIGYWAL GPLEGDPYVD GQLEYLDKAV EWAGAAGLKV LIDLHGAPGS 150
QNGFDNSGRR GAIQWQQGDT VEQTLDAFDL LAERYLGSDT VAAIEAINEP 200
NIPGGVDQGK LQEYYGSVYG IVNKYNAGTS VVYGDGFLPV ESWNGFKTEG 250
SKVVMDTHHY HMFDNGLIAM DIDSHIDAVC QFAHQHLEAS DKPVIVGEWT 300
GAVTDCAKYL NGKGNGARYD GSYAADKAIG DCSSLATGFV SKLSDEERSD 350
MRRFIEAQLD AFELKSGWVF WTWKTEGAPG WDMSDLLEAG VFPTSPDDRE 400
FPKQC 405
Length:405
Mass (Da):44,373
Last modified:March 3, 2009 - v1
Checksum:iFC8D181C0A37A7C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963473 Genomic DNA. Translation: EED55554.1.
RefSeqiXP_002374336.1. XM_002374295.1.

Genome annotation databases

EnsemblFungiiCADAFLAT00002201; CADAFLAP00002201; CADAFLAG00002201.
GeneIDi7910329.
KEGGiafv:AFLA_028260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EQ963473 Genomic DNA. Translation: EED55554.1 .
RefSeqi XP_002374336.1. XM_002374295.1.

3D structure databases

ProteinModelPortali B8N151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5059.CADAFLAP00002201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFLAT00002201 ; CADAFLAP00002201 ; CADAFLAG00002201 .
GeneIDi 7910329.
KEGGi afv:AFLA_028260.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi QYPNICG.
OrthoDBi EOG7JT75H.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Aspergillus flavus strain NRRL 3357."
    Payne W.G.A., Dean R.A., Nierman W.C., Amedeo P., Caler E.G.A., Fedorova N.D., Maiti R., Joardar V., Inman J., Galinsky K.J., Yu J., Bhatnagar D., Cleveland T.E.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167.

Entry informationi

Entry nameiEXGA_ASPFN
AccessioniPrimary (citable) accession number: B8N151
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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